Calcium‐mobilizing purine receptors on the surface of mammalian articular chondrocytes

A new generation of Ca2+ indicators with greatly improved fluorescence properties.

1985 • 21,873 citations

INOSITOL TRISPHOSPHATE AND DIACYLGLYCEROL: TWO INTERACTING SECOND MESSENGERS

1987 • 3,302 citations

A model for receptor-regulated calcium entry

1986 • 2,535 citations

ROLE OF CYTOKINES IN RHEUMATOID ARTHRITIS

1996 • 2,527 citations

Extracellular ATP: effects, sources and fate

1986 • 1,666 citations

Cytokine signal transduction

1994 • 1,358 citations

Is there a basis for distinguishing two types of P2-purinoceptor?

1985 • 1,353 citations

A Direct Spectrophotometric Microassay for Sulfated Glycosaminoglycans in Cartilage Cultures

1982 • 1,345 citations

Signal transduction via P2-purinergic receptors for extracellular ATP and other nucleotides

1993 • 1,259 citations

Cell membrane receptors for drugs and hormones: A multidisciplinary approach

1979 • 850 citations

Expression cloning of an ATP receptor from mouse neuroblastoma cells.

1993 • 587 citations

Thapsigargin, a novel molecular probe for studying intracellular calcium release and storage

1989 • 583 citations

Activation by Extracellular Nucleotides of Chloride Secretion in the Airway Epithelia of Patients with Cystic Fibrosis

1991 • 495 citations

Interleukin 1 is processed and released during apoptosis.

1991 • 459 citations

Cloned adenosine A3 receptors: Pharmacological properties, species differences and receptor functions

1994 • 395 citations

Alteration of intracellular Fura-2 fluorescence by viscosity: A simple correction

1990 • 319 citations

Message Transmission: Receptor Controlled Adenylate Cyclase System

1984 • 275 citations

Cloning and Functional Expression of a Human Uridine Nucleotide Receptor

1995 • 250 citations

Growth factor responsiveness of human articular chondrocytes in aging and development

1995 • 201 citations

Extracellular ATP and cell signalling

1992 • 201 citations

Cloning, Expression, and Chromosomal Localization of the Human Uridine Nucleotide Receptor Gene

1995 • 193 citations

Extracellular ATP activates a cation conductance and a K+ conductance in cultured microglial cells from mouse brain

1993 • 173 citations

Cloning of Rat and Mouse P2Y Purinoceptors

1995 • 158 citations

Chondrocyte-mediated depletion of articular cartilage proteoglycans in vitro

1985 • 150 citations

Inhibition of cartilage proteoglycan synthesis by interleukin 1

1988 • 146 citations

ATP induces the release of IL-1 from LPS-primed cells in vivo.

1995 • 130 citations

Synovial fluid ATP: a potential substrate for the production of inorganic pyrophosphate.

1991 • 126 citations

Skeletal Tissue Response to Cytokines

1990 • 116 citations

Cloning and Characterization of a Bovine P2Y Receptor ∮

1995 • 114 citations

Identification and cloning of human P2U purinoceptor present in osteoclastoma, bone, and osteoblasts

1995 • 102 citations

ATP stimulates secretion in human neutrophils and HL60 cells via a pertussis toxin‐sensitive guanine nucleotide‐binding protein coupled to phospholipase C

1989 • 102 citations

The biological actions of extracellular ATP

1989 • 96 citations

Purinergic regulation of bradykinin-induced plasma extravasation and adjuvant-induced arthritis in the rat.

1991 • 87 citations

Purinergic regulation of cytosolic calcium and phosphoinositide metabolism in rat osteoblast-like osteosarcoma cells

1991 • 69 citations

Nucleotide receptor P2u partially mediates ATP-induced cell cycle progression of aortic smooth muscle cells

1996 • 67 citations

Characterization of ATP-induced vasodilation in the human forearm vascular bed.

1994 • 66 citations

Extracellular ATP Enhances mRNA Levels of Nitric Oxide Synthase and TNF-α in Lipopolysaccharide-Treated Raw 264.7 Murine Macrophages

1995 • 64 citations

Regulation of matrix metabolism in equine cartilage explant cultures by interleukin 1

1992 • 58 citations

A Gs protein couples P2-purinergic stimulation to cardiac Ca channels without cyclic AMP production.

1992 • 58 citations

Mechanisms of cell damage and enzyme release.

1994 • 56 citations

Calcium-dependent release of arachidonic acid in response to purinergic receptor activation in airway epithelium

1994 • 54 citations

Multiple signal transduction pathways lead to extracellular ATP‐stimulated mitogenesis in mammalian cells: II. A pathway involving arachidonic acid release, prostaglandin synthesis, and cyclic AMP accumulation

1991 • 53 citations

Stimulation of cartilage resorption by extracellular ATP acting at P2-purinoceptors

1994 • 53 citations

Extracellular atp triggers two functionally distinct calcium signalling pathways in pc12 cells

1994 • 52 citations

Cloning and Chromosomal Localization of the Human A2b Adenosine Receptor Gene (ADORA2B) and Its Pseudogene

1995 • 50 citations

Evidence for the presence of P2-purinoceptors at the surface of human articular chondrocytes in monolayer culture

1991 • 49 citations

Review: Ca2+-mobilizing receptors for ATP and UTP

1995 • 48 citations

Functional studies in the human submandibular duct cell line, HSG-PA, suggest a second salivary gland receptor subtype for nucleotides.

1991 • 46 citations

Roles of Ca2+ influx through ATP-activated channels in catecholamine release from pheochromocytoma PC12 cells

1992 • 44 citations

Identification of a novel inflammatory stimulant of chondrocytes. Early events in cell activation by bradykinin receptors on pig articular chondrocytes

1989 • 42 citations

Dual regulation of arachidonic acid release by P2U purinergic receptors in dibutyryl cyclic AMP-differentiated HL60 cells.

1992 • 38 citations

Identification of ecto-nucleoside triphosphate pyrophosphatase in human articular chondrocytes in monolayer culture

1985 • 30 citations

The intracellular Ca2+-pump inhibitors thapsigargin and cyclopiazonic acid induce stress proteins in mammalian chondrocytes

1994 • 30 citations

Evidence that ecto-nucleoside-triphosphate pyrophosphatase serves in the generation of extracellular inorganic pyrophosphate in human bone and articular cartilage

1988 • 28 citations

Calcium signaling in endothelin- and platelet-derived growth factor-stimulated chondrocytes

1994 • 27 citations

Calcium pyrophosphate crystal deposition disease and other crystal deposition diseases

1995 • 26 citations

Effect of bacterial lipopolysaccharides on sulfated glycosaminoglycan metabolism and prostaglandin E2 synthesis in equine cartilage explant cultures

1994 • 26 citations

Extracellular ATP and UTP Increase Cytosolic Free Calcium by Activating a Common P2U-Receptor in Single Human Thyrocytes

1995 • 25 citations

Activation of protein kinase C inhibits ATP‐induced [Ca²⁺]_i elevation in rat osteoblastic cells: Selective effects on P_2Y and P_2U signaling pathways

1995 • 24 citations

Purinoceptor P2U identification and function in human intrahepatic biliary epithelial cell lines

1995 • 23 citations

Biphasic and differential modulation of Ca2+ entry by ATP and UTP in promyelocytic leukaemia HL60 cells

1995 • 22 citations

ATP‐activated Ca²⁺‐permeable channels in rat peritoneal macrophages

1992 • 21 citations

Interleukin-1β enhances the response of human articular chondrocytes to extracellular ATP

1992 • 21 citations

Cellular signaling responses mediated by a novel nucleotide receptor in rabbit microvessel endothelium

1993 • 18 citations

Adenine nucleotides mobilize cellular Ca2+ and inhibit parathyroid hormone secretion

1989 • 17 citations

Serum fractions and related agonists with calcium‐mobilizing activity in the bovine growth plate chondrocyte

1995 • 14 citations

Pharmacological characterization of the nucleotide receptors that mobilize Ca2+ ions in human parathyroid cells

1994 • 12 citations

Isolation and characterization of an avian A1 adenosine receptor gene and a related cDNA clone

1995 • 12 citations

Adenosine and ATP: from receptor structure to clinical applications

1994 • 12 citations

Ca2+ Influx Through Voltage- and Purinoceptor-Operated Channels Estimated from [Ca2+]C Signals (Myocytes from Guinea-Pig Urinary Bladder)

1992 • 10 citations

Signal Transduction in Leukocytes: G Protein-Related and Other Pathways

1995 • 7 citations

Genistein inhibits calcium release by platelet-derived growth factor but not bradykinin or cadmium in human fibroblasts

1993 • 6 citations

Technology Initiative Initiated

1992 • 3 citations