The intracellular Ca2+-pump inhibitors thapsigargin and cyclopiazonic acid induce stress proteins in mammalian chondrocytes

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Short-Term Effects of Nose-Only Cigarette Smoke Exposure on Glutathione Redox Homeostasis, Cytochrome P450 1A1/2 and Respiratory Enzyme Activities in Mice Tissues

2013 • 47,043 citations

High resolution two-dimensional electrophoresis of proteins.

1975 • 19,515 citations

Thapsigargin, a tumor promoter, discharges intracellular Ca2+ stores by specific inhibition of the endoplasmic reticulum Ca2(+)-ATPase.

1990 • 3,250 citations

Thapsigargin inhibits the sarcoplasmic or endoplasmic reticulum Ca-ATPase family of calcium pumps.

1991 • 1,282 citations

Heat shock, stress proteins, chaperones, and proteotoxicity

1991 • 1,069 citations

HSP104 Required for Induced Thermotolerance

1990 • 822 citations

Cyclopiazonic Acid is a Specific Inhibitor of the Ca2+-ATPase of Sarcoplasmic Reticulum

1989 • 750 citations

Heat Shock Is Lethal to Fibroblasts Microinjected with Antibodies Against hsp70

1988 • 635 citations

Thapsigargin, a novel molecular probe for studying intracellular calcium release and storage

1989 • 583 citations

Mammalian stress response: induction of the glucose-regulated protein family

1992 • 452 citations

Persistent intracellular calcium pool depletion by thapsigargin and its influence on cell growth.

1991 • 206 citations

Calcium-Dependent Regulation of Protein Synthesis in Intact Mammalian Cells

1990 • 198 citations

Depletion of intracellular calcium stores by calcium ionophore A23187 induces the genes for glucose-regulated proteins in hamster fibroblasts.

1987 • 195 citations

Drug action of thapsigargin on the Ca2+ pump protein of sarcoplasmic reticulum.

1991 • 162 citations

Stress proteins in biology and medicine

1991 • 154 citations

Heat shock: the role of transient inducible responses in cell damage, transformation, and differentiation.

1991 • 154 citations

Inhibition of cartilage proteoglycan synthesis by interleukin 1

1988 • 146 citations

The role of heat-shock proteins as molecular chaperones

1991 • 143 citations

Calcium ionophore A23187 as a regulator of gene expression in mammalian cells.

1986 • 109 citations

Brefeldin A, thapsigargin, and AlF stimulate the accumulation of GRP78 mRNA in a cycloheximide dependent manner, whilst induction by hypoxia is independent of protein synthesis

1992 • 98 citations

Regulation of c-fos and c-jun protooncogene expression by the Ca(2+)-ATPase inhibitor thapsigargin.

1991 • 83 citations

Stress‐induced proteins in chondrocytes from patients with osteoarthritis

1985 • 69 citations

Accommodation of protein synthesis to chronic deprivation of intracellular sequestered calcium. A putative role for GRP78

1990 • 59 citations

Modulation and Reexpression of the Chondrocyte Phenotype; Mediation by Cell Shape and Microfilament Modification

1988 • 49 citations

Gamma/Delta T Lymphocytes and Heat Shock Proteins

1991 • 47 citations

Identification of a novel inflammatory stimulant of chondrocytes. Early events in cell activation by bradykinin receptors on pig articular chondrocytes

1989 • 42 citations

An intracellular calcium store regulates protein synthesis in HeLa cells, but it is not the hormone-sensitive store

1992 • 39 citations

Stimulation of GRP78 gene transcription by phorbol ester and cAMP in GH3 pituitary cells. The accommodation of protein synthesis to chronic deprivation of intracellular sequestered calcium.

1991 • 23 citations

Natural Products and Drug Development

1986 • 5 citations