Multiple regions of TBP participate in the response to transcriptional activators in vivo.

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

1983 • 11,902 citations

[6] Use of T7 RNA polymerase to direct expression of cloned genes

1990 • 6,681 citations

[19] Rapid and efficient site-specific mutagenesis without phenotypic selection

1987 • 5,413 citations

Analysis of Sp1 in vivo reveals mutiple transcriptional domains, including a novel glutamine-rich activation motif

1988 • 1,403 citations

Transcriptional activation: A complex puzzle with few easy pieces

1994 • 1,112 citations

Crystal structure of a yeast TBP/TATA-box complex

1993 • 1,082 citations

A multiprotein mediator of transcriptional activation and its interaction with the C-terminal repeat domain of RNA polymerase II

1994 • 1,064 citations

Co-crystal structure of TBP recognizing the minor groove of a TATA element

1993 • 1,039 citations

Functional dissection of VP16, the trans-activator of herpes simplex virus immediate early gene expression.

1988 • 830 citations

The proline-rich transcriptional activator of CTF/NF-I is distinct from the replication and DNA binding domain

1989 • 781 citations

Isolation of coactivators associated with the TATA-binding protein that mediate transcriptional activation

1991 • 711 citations

Differential transcriptional activation by Oct-1 and Oct-2: Interdependent activation domains induce Oct-2 phosphorylation

1990 • 696 citations

TBP, a universal eukaryotic transcription factor?

1993 • 642 citations

Molecular cloning and functional analysis of Drosophila TAF110 reveal properties expected of coactivators

1993 • 589 citations

An RNA polymerase II holoenzyme responsive to activators

1994 • 586 citations

Mechanism of action of an acidic transcriptional activator in vitro

1991 • 557 citations

A multisubunit complex associated with the RNA polymerase II CTD and TATA-binding protein in yeast

1993 • 465 citations

Drosophila TAFII40 interacts with both a VP16 activation domain and the basal transcription factor TFIIB

1993 • 418 citations

Crystal structure of TFIID TATA-box binding protein

1992 • 410 citations

The basics of basal transcription by RNA polymerase II

1994 • 409 citations

The TATA-binding protein is required for transcription by all three nuclear RNA polymerases in yeast cells

1992 • 392 citations

Initiation of Transcription by RNA Polymerase II: A Multi-step Process

1993 • 390 citations

Coactivators for a proline-rich activator purified from the multisubunit human TFIID complex.

1991 • 381 citations

Binding of general transcription factor TFIIB to an acidic activating region

1991 • 377 citations

Assembly of recombinant TFIID reveals differential coactivator requirements for distinct transcriptional activators

1994 • 374 citations

Reduced binding of TFIID to transcriptionally compromised mutants of VP16

1991 • 362 citations

The structural stability of a protein is an important determinant of its proteolytic susceptibility in Escherichia coli

1989 • 326 citations

Eukaryotic activators function during multiple steps of preinitiation complex assembly

1993 • 311 citations

Direct interaction between Sp1 and the BPV enhancer E2 protein mediates synergistic activation of transcription

1991 • 311 citations

An amino-terminal fragment of GAL4 binds DNA as a dimer

1989 • 296 citations

Species-specific interaction of the glutamine-rich activation domains of Sp1 with the TATA box-binding protein.

1994 • 266 citations

Pattern of aromatic and hydrophobic amino acids critical for one of two subdomains of the VP16 transcriptional activator.

1993 • 261 citations

TBP-TAF complexes: selectivity factors for eukaryotic transcription

1994 • 250 citations

The Zta trans-activator protein stabilizes TFIID association with promoter DNA by direct protein-protein interaction.

1991 • 249 citations

Cloning and expression of human TAFII250: a TBP-associated factor implicated in cell-cycle regulation

1993 • 234 citations

Multiple functional domains of human transcription factor IIB: distinct interactions with two general transcription factors and RNA polymerase II.

1993 • 229 citations

Variants of the TATA-binding protein can distinguish subsets of RNA polymerase I, II, and III promoters

1992 • 228 citations

Promoter-selective activation domains in Oct-1 and Oct-2 direct differential activation of an snRNA and mRNA promoter

1992 • 225 citations

Multiple sequence elements of a single functional class are required for cyclic AMP responsiveness of the mouse c-fos promoter.

1989 • 220 citations

Drosophila TAF _II 150: Similarity to Yeast Gene TSM-1 and Specific Binding to Core Promoter DNA

1994 • 212 citations

Direct interaction between the transcriptional activation domain of human p53 and the TATA box-binding protein.

1993 • 209 citations

A mechanism for TAFs in transcriptional activation: activation domain enhancement of TFIID-TFIIA--promoter DNA complex formation.

1994 • 207 citations

Largest subunit of Drosophila transcription factor IID directs assembly of a complex containing TBP and a coactivator

1993 • 176 citations

Activation of the U2 snRNA promoter by the octamer motif defines a new class of RNA polymerase II enhancer elements.

1988 • 174 citations

Promoter-Selective Transcriptional Defect in Cell Cycle Mutant ts13 Rescued by hTAF _II 250

1994 • 163 citations

Multiple domains of the RNA polymerase I activator hUBF interact with the TATA-binding protein complex hSL1 to mediate transcription.

1992 • 159 citations

Yeast and human TFIID with altered DNA-binding specificity for TATA elements

1992 • 155 citations

A single amino acid exchange transfers VP16-induced positive control from the Oct-1 to the Oct-2 homeo domain.

1992 • 134 citations

Dominant negative mutations in yeast TFIID define a bipartite DNA-binding region

1991 • 132 citations

Sp1 activates transcription without enhancing DNA-binding activity of the TATA box factor.

1989 • 123 citations

Functional differences between yeast and human TFIID are localized to the highly conserved region

1991 • 121 citations

TFIIA induces conformational changes in TFIID via interactions with the basic repeat.

1992 • 119 citations

Regional Codon Randomization: Defining a TATA-Binding Protein Surface Required for RNA Polymerase III Transcription

1993 • 95 citations

Transcription Factor IID Mutants Defective for Interaction with Transcription Factor IIA

1992 • 95 citations

Factors (TAFs) required for activated transcription interact with TATA box-binding protein conserved core domain.

1993 • 89 citations

Immunopurification of yeast TATA-binding protein and associated factors. Presence of transcription factor IIIB transcriptional activity

1993 • 88 citations

Synergistic transcriptional activation by CTF/NF-I and the estrogen receptor involves stabilized interactions with a limiting target factor.

1991 • 81 citations

Functional differences between mammalian transcription activation domains at the yeast GAL1 promoter.

1994 • 72 citations

The Oct-2 glutamine-rich and proline-rich activation domains can synergize with each other or duplicates of themselves to activate transcription.

1994 • 70 citations

Yeast and human TFIIDs are interchangeable for the response to acidic transcriptional activators in vitro.

1992 • 70 citations

A bipartite DNA binding domain composed of direct repeats in the TATA box binding factor TFIID.

1992 • 60 citations

Residues in the TATA-binding protein required to mediate a transcriptional response to retinoic acid in EC cells

1993 • 58 citations

Conserved and nonconserved functions of the yeast and human TATA-binding proteins.

1994 • 44 citations

Reconstitution of transcriptional activation domains by reiteration of short peptide segments reveals the modular organization of a glutamine-rich activation domain.

1994 • 43 citations

Both Arabidopsis TATA binding protein (TBP) isoforms are functionally identical in RNA polymerase II and III transcription in plant cells: evidence for gene-specific changes in DNA binding specificity of TBP.

1993 • 36 citations