Kainic Acid-Induced Seizures Enhance Dentate Gyrus Inhibition by Downregulation of GABA_BReceptors

A permanent change in brain function resulting from daily electrical stimulation

1969 • 3,056 citations

Sequence and functional expression of the GABAA receptor shows a ligand-gated receptor super-family

1987 • 1,621 citations

Evidence of functional mossy fiber sprouting in hippocampal formation of kainic acid-treated rats

1985 • 1,101 citations

Decreased Hippocampal Inhibition and a Selective Loss of Interneurons in Experimental Epilepsy

1987 • 1,077 citations

Synaptic Reorganization in the Hippocampus Induced by Abnormal Functional Activity

1988 • 912 citations

Paired‐pulse depression of monosynaptic GABA‐mediated inhibitory postsynaptic responses in rat hippocampus.

1990 • 709 citations

Circuit Mechanisms of Seizures in the Pilocarpine Model of Chronic Epilepsy: Cell Loss and Mossy Fiber Sprouting

1993 • 696 citations

A physiological role for GABAB receptors in the central nervous system

1988 • 643 citations

Mossy fiber synaptic reorganization induced by kindling: time course of development, progression, and permanence

1991 • 539 citations

Feed‐forward dendritic inhibition in rat hippocampal pyramidal cells studied in vitro

1982 • 531 citations

Comparison of the actions of adenosine at pre‐ and postsynaptic receptors in the rat hippocampus in vitro.

1992 • 486 citations

Zinc-Induced Collapse of Augmented Inhibition by GABA in a Temporal Lobe Epilepsy Model

1996 • 419 citations

Progressive neuronal loss induced by kindling: a possible mechanism for mossy fiber synaptic reorganization and hippocampal sclerosis

1990 • 408 citations

Possible functional consequences of synaptic reorganization in the dentate gyrus of kainate-treated rats

1992 • 369 citations

Presynaptic inhibition of miniature excitatory synaptic currents by baclofen and adenosine in the hippocampus

1992 • 369 citations

A simple perfusion chamber for the study of nervous tissue slices in vitro

1979 • 368 citations

Frequency‐dependent depression of inhibition in guinea‐pig neocortex in vitro by GABAB receptor feed‐back on GABA release.

1989 • 348 citations

Hippocampal mossy fiber sprouting and synapse formation after status epilepticus in rats: Visualization after retrograde transport of biocytin

1995 • 339 citations

The effects of kindling on GABA-Mediated inhibition in the dentate gyrus of the rat. I. Paired-pulse depression

1983 • 333 citations

CGP 35348: a centrally active blocker of GABAB receptors

1990 • 303 citations

Kainic acid seizures in the developing brain: status epilepticus and spontaneous recurrent seizures

1992 • 300 citations

Electrophysiology of dentate granule cells after kainate-induced synaptic reorganization of the mossy fibers

1992 • 279 citations

Lasting potentiation of inhibition is associated with an increased number of gamma-aminobutyric acid type A receptors activated during miniature inhibitory postsynaptic currents.

1994 • 263 citations

Activation of N-methyl-D-aspartate receptors parallels changes in cellular and synaptic properties of dentate gyrus granule cells after kindling

1988 • 261 citations

Resistance of the immature hippocampus to seizure-induced synaptic reorganization

1991 • 245 citations

Synaptic connections of dentate granule cells and hilar neurons: Results of paired intracellular recordings and intracellular horseradish peroxidase injections

1990 • 240 citations

Abnormal neuronal excitability in hippocampal slices from kindled rats

1985 • 206 citations

Comparison of the actions of baclofen at pre‐ and postsynaptic receptors in the rat hippocampus in vitro.

1992 • 203 citations

The Effects of Kindling on GABA-mediated Inhibition in the Dentate Gyrus of the Rat

1982 • 195 citations

The GABAA receptors

1995 • 181 citations

Epilepsy induced collateral sprouting of hippocampal mossy fibers: Does it induce the development of ectopic synapses with granule cell dendrites?

1993 • 180 citations

Activity-dependent disinhibition. III. Desensitization and GABAB receptor-mediated presynaptic inhibition in the hippocampus in vitro

1989 • 177 citations

The physiological regulation of synaptic inhibition by GABAB autoreceptors in rat hippocampus.

1993 • 174 citations

Properties of NMDA receptor channels in neurons acutely isolated from epileptic (kindled) rats

1993 • 170 citations

Epileptogenic Effects of Status Epilepticus

1993 • 141 citations

The development and decay of kindling-induced increases in paired-pulse depression in the dentate gyrus

1987 • 134 citations

Calcium and transmitter release

1993 • 128 citations

Alterations of inhibitory processes in the dentate gyrus following kindling-induced epilepsy

1985 • 125 citations

Effects of kainic acid on seizure susceptibility in the developing brain

1988 • 121 citations

Effects of (?)baclofen on inhibitory neurons in the guinea pig hippocampal slice

1989 • 116 citations

Kindling enhances sensitivity of CA3 hippocampal pyramidal cells to NMDA

1992 • 114 citations

CGP 55845A: A potent antagonist of GABAb receptors in the CA1 region of rat hippocampus

1993 • 113 citations

GABAB autoreceptors mediate activity-dependent disinhibition and enhance signal transmission in the dentate gyrus

1993 • 105 citations

Lasting potentiation of inhibition is associated with an increased number of GABA_A receptors activated during miniature inhibitory postsynaptic currents

1994 • 99 citations

Temporally distinct mechanisms of use-dependent depression at inhibitory synapses in the rat hippocampus in vitro

1994 • 92 citations

Effects of baclofen and bicuculline on inhibition in the fascia dentata and hippocampus regio superior

1991 • 88 citations

Differences between presynaptic and postsynaptic GABAB mechanisms in rat hippocampal pyramidal cells

1994 • 86 citations

Alteration in dentate neuronal activities associated with perforant path kindling

1987 • 80 citations

Alteration in dentate neuronal activities associated with perforant path kindling

1987 • 74 citations

Changes in inhibitory processes in the hippocampus following recurrent seizures induced by systemic administration of kainic acid

1991 • 73 citations

The Imaging of Individual Atoms

1996 • 72 citations

Different mechanisms for use‐dependent depression of two GABAA‐mediated IPSCs in rat hippocampus.

1995 • 72 citations

Evidence for a chronic loss of inhibition in the hippocampus after kindling: electrophysiological studies

1989 • 71 citations

Baclofen: Effects on evoked field potentials and amino acid neurotransmitter release in the rat olfactory cortex slice

1982 • 68 citations

Kindling increases N-methyl-d-aspartate potency at single N-methyl-d-aspartate channels in dentate gyrus granule cells

1994 • 65 citations

NMDA receptors have a dominant role in population spike-paired pulse facilitation in the dentate gyrus of urethane-anesthetized rats

1993 • 56 citations

The actions of 2-hydroxy-saclofen at presynaptic GABAB receptors in the rat hippocampus

1990 • 48 citations

Development of spontaneous seizures over extended electrical kindling. II. Persistence of dentate inhibitory suppression

1995 • 44 citations

Discrimination of post- and presynaptic GABAB receptor-mediated responses by tetrahydroaminoacridine in area CA3 of the rat hippocampus

1993 • 43 citations

Potentiation of inhibition with perforant path kindling: an NMDA-receptor dependent process

1991 • 39 citations

Hippocampal kindling induced paired-pulse depression in the dentate gyrus and paired-pulse facilitation in CA3

1992 • 38 citations

Structure and function of cerebral GABAA and GABAB receptors

1993 • 37 citations

Effects of kindling on subsequent learning, memory, behavior, and seizure susceptibility

1993 • 37 citations

The effect of kindling beyond the ‘stage 5’ criterion on paired-pulse depression and hilar cell counts in the dentate gyrus

1994 • 36 citations

Contribution of presynaptic GABA-B receptors to paired-pulse depression of GABA responses in the hippocampus

1994 • 33 citations

The GABAB receptor antagonist, CGP-35348, inhibits paired-pulse disinhibition in the rat dentate gyrus in vivo

1992 • 32 citations

Decreased heterosynaptic and homosynaptic paired pulse inhibition in the rat hippocampus as a chronic sequela to limbic status epilepticus

1993 • 21 citations

Mutual interactions between repeated flurothyl convulsions and electrical kindling

1987 • 11 citations

Synaptic activation in guinea-pig dentate area: dependence on the stimulation site

1993 • 9 citations

Genes for the GABAA receptor subunit types and their expression.

1992 • 7 citations

Deleted Work

1955 • 0 citations