Myeloid leukemia factor 1 regulates p53 by suppressing COP1 via COP9 signalosome subunit 3

Surfing the p53 network

2000 • 6,487 citations

The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

1993 • 5,680 citations

High-efficiency transformation of mammalian cells by plasmid DNA.

1987 • 5,377 citations

Inhibitors of mammalian G1 cyclin-dependent kinases.

1995 • 3,258 citations

Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells

2003 • 1,851 citations

Chromosomal translocations in human cancer

1994 • 1,551 citations

The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus

1999 • 1,549 citations

The retinoblastoma protein associates with the protein phosphatase type 1 catalytic subunit.

1993 • 1,459 citations

Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells

2003 • 1,435 citations

Hematopoietic Stem Cell Quiescence Maintained by p21 ^cip1/waf1

2000 • 1,326 citations

Oncogenic Transcription Factors in the Human Acute Leukemias

1997 • 1,227 citations

Major nucleolar proteins shuttle between nucleus and cytoplasm

1989 • 1,113 citations

Genetic Alterations of Cyclins, Cyclin-Dependent Kinases, and Cdk Inhibitors in Human Cancer

1996 • 751 citations

Pirh2, a p53-Induced Ubiquitin-Protein Ligase, Promotes p53 Degradation

2003 • 708 citations

The ubiquitin ligase COP1 is a critical negative regulator of p53

2004 • 693 citations

Promotion of NEDD8-CUL1 Conjugate Cleavage by COP9 Signalosome

2001 • 687 citations

Role of Predicted Metalloprotease Motif of Jab1/Csn5 in Cleavage of Nedd8 from Cul1

2002 • 680 citations

Degradation of the cyclin-dependent-kinase inhibitor p27Kip1 is instigated by Jab1

1999 • 624 citations

Mdm2-Mediated NEDD8 Conjugation of p53 Inhibits Its Transcriptional Activity

2004 • 541 citations

Properties of haematopoietic stem cells surviving 5-fluorouracil treatment: evidence for a pre-CFU-S cell?

1979 • 513 citations

Nucleophosmin regulates the stability and transcriptional activity of p53

2002 • 509 citations

The COP9 Signalosome

2003 • 480 citations

Tumor Suppressor ARF Degrades B23, a Nucleolar Protein Involved in Ribosome Biogenesis and Cell Proliferation

2003 • 430 citations

Nucleolar protein NPM interacts with HDM2 and protects tumor suppressor protein p53 from HDM2-mediated degradation

2004 • 403 citations

The nucleolus: an old factory with unexpected capabilities

2000 • 398 citations

Physical and Functional Interactions of the Arf Tumor Suppressor Protein with Nucleophosmin/B23

2004 • 383 citations

A novel protein complex involved in signal transduction possessing similarities to 26S proteasome subunits

1998 • 371 citations

Arabidopsis COP9 is a component of a novel signaling complex mediating light control of development

1994 • 363 citations

The Cytoplasmic Shuttling and Subsequent Degradation of p27Kip1 Mediated by Jab1/CSN5 and the COP9 Signalosome Complex

2002 • 310 citations

The t(3;5)(q25.1;q34) of myelodysplastic syndrome and acute myeloid leukemia produces a novel fusion gene, NPM-MLF1.

1996 • 284 citations

5-Fluorouracil spares hemopoietic stem cells responsible for long-term repopulation.

1990 • 247 citations

Making sense of the COP9 signalosome: a regulatory protein complex conserved from Arabidopsis to human

1999 • 237 citations

COP9 signalosome revisited: a novel mediator of protein degradation

2001 • 221 citations

Protein kinase CK2 and protein kinase D are associated with the COP9 signalosome

2003 • 200 citations

Regulating the p53 system through ubiquitination

2004 • 179 citations

The COP9 Signalosome Inhibits p27kip1 Degradation and Impedes G1-S Phase Progression via Deneddylation of SCF Cul1

2002 • 170 citations

Multiple Functions of Jab1 Are Required for Early Embryonic Development and Growth Potential in Mice

2004 • 158 citations

Translocation of nucleolar phosphoprotein B23 () induced by selective inhibitors of ribosome synthesis

1985 • 148 citations

Cell cycle inhibitors in normal and tumor stem cells

2004 • 102 citations

Evidence for FUS6 as a component of the nuclear-localized COP9 complex in Arabidopsis.

1996 • 99 citations

Inositol 1,3,4-Trisphosphate 5/6-Kinase Associates with the COP9 Signalosome by Binding to CSN1

2002 • 99 citations

Identification of differentially expressed genes in human lung squamous cell carcinoma using suppression subtractive hybridization

2004 • 84 citations

Clinicopathologic manifestations and breakpoints of the t(3;5) in patients with acute nonlymphocytic leukemia.

1989 • 81 citations

A role ofArabidopsisCOP9 signalosome in multifaceted developmental processes revealed by the characterization of its subunit 3

2001 • 76 citations

The Jab1/COP9 signalosome subcomplex is a downstream mediator of Bcr-Abl kinase activity and facilitates cell-cycle progression

2004 • 74 citations

Elevated MLF1 expression correlates with malignant progression from myelodysplastic syndrome

2000 • 53 citations

Small Jab1‐containing subcomplex is regulated in an anchorage‐ and cell cycle‐dependent manner, which is abrogated by ras transformation

2005 • 50 citations

HLS7, a hemopoietic lineage switch gene homologous to the leukemia-inducing gene MLF1

1999 • 45 citations

Apoptosis induced by the myelodysplastic syndrome-associated NPM-MLF1 chimeric protein

1999 • 30 citations