NH2-terminally truncated HER-2/neu protein: relationship with shedding of the extracellular domain and with prognostic factors in breast cancer.

Human Breast Cancer: Correlation of Relapse and Survival with Amplification of the HER-2/ neu Oncogene

1987 • 11,429 citations

Studies of the HER-2/ neu Proto-Oncogene in Human Breast and Ovarian Cancer

1989 • 6,734 citations

Tyrosine Kinase Receptor with Extensive Homology to EGF Receptor Shares Chromosomal Location with neu Oncogene

1985 • 1,804 citations

erb B-2 Is a Potent Oncogene When Overexpressed in NIH/3T3 Cells

1987 • 1,015 citations

The biology of erbB-2/nue/HER-2 and its role in cancer

1994 • 975 citations

Membrane protein secretases

1997 • 634 citations

Frequent expression of a mutant epidermal growth factor receptor in multiple human tumors.

1995 • 633 citations

Increased expression of the putative growth factor receptor p185HER2 causes transformation and tumorigenesis of NIH 3T3 cells.

1987 • 627 citations

Overexpression of the EGF receptor-related proto-oncogene erbB-2 in human mammary tumor cell lines by different molecular mechanisms.

1987 • 619 citations

Protection against a lethal dose of endotoxin by an inhibitor of tumour necrosis factor processing

1994 • 607 citations

The Enhanced Tumorigenic Activity of a Mutant Epidermal Growth Factor Receptor Common in Human Cancers Is Mediated by Threshold Levels of Constitutive Tyrosine Phosphorylation and Unattenuated Signaling

1997 • 591 citations

HER-2/neu oncogene protein and prognosis in breast cancer.

1989 • 579 citations

Regulation of tumour necrosis factor-α processing by a metalloproteinase inhibitor

1994 • 571 citations

p185neu expression in human lung adenocarcinomas predicts shortened survival.

1990 • 440 citations

Oncogenic activation of the neu-encoded receptor protein by point mutation and deletion.

1988 • 321 citations

Elevated serum c-erbB-2 antigen levels and decreased response to hormone therapy of breast cancer.

1995 • 312 citations

Membrane proteins with soluble counterparts: role of proteolysis in the release of transmembrane proteins

1991 • 287 citations

Prediction of response to antiestrogen therapy in advanced breast cancer patients by pretreatment circulating levels of extracellular domain of the HER-2/c-neu protein.

1997 • 250 citations

Ligand and protein kinase C downmodulate the colony-stimulating factor 1 receptor by independent mechanisms.

1989 • 228 citations

The extracellular domain of p185/neu is released from the surface of human breast carcinoma cells, SK-BR-3

1991 • 205 citations

Transformational and altered signal transduction by a naturally occurring mutant EGF receptor.

1996 • 195 citations

Different structural alterations upregulate in vitro tyrosine kinase activity and transforming potency of the erbB-2 gene.

1988 • 186 citations

The neu-oncogene: signal transduction pathways, transformation mechanisms and evolving therapies.

1994 • 186 citations

Selective Cleavage of the Heregulin Receptor ErbB-4 by Protein Kinase C Activation

1996 • 176 citations

A truncated intracellular HER2/neu receptor produced by alternative RNA processing affects growth of human carcinoma cells.

1993 • 161 citations

The Transforming Receptor Tyrosine Kinase, Axl, Is Post-translationally Regulated by Proteolytic Cleavage

1995 • 159 citations

Kinetics of insulin receptor internalization and recycling in adipocytes. Shunting of receptors to a degradative pathway by inhibitors of recycling.

1985 • 140 citations

Oncogenic activation of tyrosine kinases

1994 • 138 citations

Elevated soluble c-erbB-2 antigen levels in the serum and effusions of a proportion of breast cancer patients.

1992 • 135 citations

Generation and characterization of monoclonal antibodies specific for the human neu oncogene product, p185.

1989 • 131 citations

Constitutive Proteolysis of the ErbB-4 Receptor Tyrosine Kinase by a Unique, Sequential Mechanism

1997 • 117 citations

Expression pattern of the neu (NGL) gene-encoded growth factor receptor protein (p185neu) in normal and transformed epithelial tissues of the digestive tract.

1989 • 112 citations

TrkA receptor ectodomain cleavage generates a tyrosine-phosphorylated cell-associated fragment.

1996 • 104 citations

A soluble protein related to the HER-2 proto-oncogene product is released from human breast carcinoma cells.

1991 • 93 citations

Soluble c-erbB-2 fragment in serum correlates with disease stage and predicts for shortened survival in patients with early-stage and advanced breast cancer

1994 • 87 citations

Soluble HER-2/neu neutralizes biologic effects of anti-HER-2/neu antibody on breast cancer cellsin vitro

1997 • 80 citations

Tissue Expression and Serum Levels of HER-2/neu in Patients with Breast Cancer

1997 • 80 citations

Utility of C-erbB-2 in tissue and in serum in the early diagnosis of recurrence in breast cancer patients: comparison with carcinoembryonic antigen and CA 15.3

1996 • 70 citations

Rapid and Long Term Effects of Protein Kinase C on Receptor Tyrosine Kinase Phosphorylation and Degradation

1995 • 67 citations

c-erbB-2 oncoprotein: A potential biomarker of advanced prostate cancer

1997 • 67 citations

The Prognostic Significance of c-erbB-2 Serum Protein in Metastatic Breast Cancer

1997 • 63 citations

HER-2/neu oncogene amplification and expression in breast and ovarian cancers.

1990 • 51 citations

Meningitis caused by Streptococcus pneumoniae showing high level resistance to penicillin

1995 • 44 citations

The c-erbB transmembrane growth factor receptors as serum biomarkers in human cancer studies

1995 • 39 citations

Elevated serum levels of p105erbB-2 in patients with advanced-stage prostatic adenocarcinoma

1996 • 35 citations

Tissue and serum c-erbB-2 and tissue EGFR in breast carcinoma: three years follow-up.

1997 • 21 citations

Insulin and epidermal growth factor stimulate phosphorylation of p185HER-2 in the breast carcinoma cell line, BT474

1990 • 15 citations