TrkA receptor ectodomain cleavage generates a tyrosine-phosphorylated cell-associated fragment.

Signal transduction by receptors with tyrosine kinase activity

1990 • 5,528 citations

Phase separation of integral membrane proteins in Triton X-114 solution.

1981 • 3,366 citations

Functions of the neurotrophins during nervous system development: What the knockouts are teaching us

1994 • 1,431 citations

Receptor Protein-Tyrosine Kinases and Their Signal Transduction Pathways

1994 • 1,309 citations

Molecular cloning and expression of an IL-6 signal transducer, gp130

1990 • 1,307 citations

Neutrophil Mac-1 and MEL-14 Adhesion Proteins Inversely Regulated by Chemotactic Factors

1989 • 1,135 citations

Targeting of cell-surface β-amyloid precursor protein to lysosomes: alternative processing into amyloid-bearing fragments

1992 • 883 citations

Signal-Dependent Membrane Protein Trafficking in the Endocytic Pathway

1993 • 808 citations

A human oncogene formed by the fusion of truncated tropomyosin and protein tyrosine kinase sequences

1986 • 795 citations

Soluble receptors for cytokines and growth factors: generation and biological function

1994 • 766 citations

Neurotrophin receptors: A window into neuronal differentiation

1992 • 704 citations

MEMBRANE-ANCHORED GROWTH FACTORS

1993 • 676 citations

Molecular and biochemical characterization of the human trk proto-oncogene.

1989 • 600 citations

Neurotrophic factors and their receptors

1995 • 583 citations

Transforming growth factor-alpha. A model for membrane-anchored growth factors.

1990 • 430 citations

Exit of newly synthesized membrane proteins from the trans cisterna of the Golgi complex to the plasma membrane.

1985 • 415 citations

Membrane Traffic in Endocytosis: Insights from Cell-Free Assays

1989 • 369 citations

Overexpression of the trk tyrosine kinase rapidly accelerates nerve growth factor-induced differentiation

1992 • 321 citations

Membrane proteins with soluble counterparts: role of proteolysis in the release of transmembrane proteins

1991 • 287 citations

Ligand-independent activation of the sevenless receptor tyrosine kinase changes the fate of cells in the developing Drosophila eye

1991 • 255 citations

Ligand and protein kinase C downmodulate the colony-stimulating factor 1 receptor by independent mechanisms.

1989 • 228 citations

Cleavage of the membrane precursor for transforming growth factor alpha is a regulated process.

1991 • 209 citations

The extracellular domain of p185/neu is released from the surface of human breast carcinoma cells, SK-BR-3

1991 • 205 citations

C-terminal truncated forms of Met, the hepatocyte growth factor receptor.

1991 • 165 citations

The Transforming Receptor Tyrosine Kinase, Axl, Is Post-translationally Regulated by Proteolytic Cleavage

1995 • 159 citations

The extracellular domain of the c-erbB-2 oncoprotein is released from tumor cells by proteolytic cleavage.

1993 • 156 citations

Identification of a truncated form of the nerve growth factor receptor.

1988 • 145 citations

Transforming growth factor-alpha and beta-amyloid precursor protein share a secretory mechanism.

1995 • 144 citations

Oncogenic activation of tyrosine kinases

1994 • 138 citations

Multiple signals activate cleavage of the membrane transforming growth factor-alpha precursor.

1991 • 129 citations

Signal transduction and the fate of the R7 photoreceptor in Drosophila

1991 • 128 citations

The cytoplasmic carboxy-terminal amino acid specifies cleavage of membrane TGFα into soluble growth factor

1992 • 126 citations

Molecular and Biochemical Characterization of the Human trk Proto-Oncogene

1989 • 124 citations

Chapter 10 Low Temperature-Induced Transport Blocks as Tools to Manipulate Membrane Traffic

1989 • 116 citations

Structural requirements for inducible shedding of the p55 tumor necrosis factor receptor.

1994 • 94 citations

Early rise of cytosolic Ca²⁺ induced by NGF in PC12 and chromaffin cells

1986 • 89 citations

Ligand and Protein Kinase C Downmodulate the Colony-Stimulating Factor 1 Receptor by Independent Mechanisms

1989 • 70 citations

Involvement of a metalloprotease in low-affinity nerve growth factor receptor truncation: inhibition of truncation in vitro and in vivo

1993 • 53 citations

C-Terminal Truncated Forms of Met, the Hepatocyte Growth Factor Receptor

1991 • 52 citations

Evidence for endocytosis-dependent proteolysis in the generation of soluble truncated nerve growth factor receptors by A875 human melanoma cells

1991 • 36 citations

Generation of the truncated form of the nerve growth factor receptor by rat Schwann cells. Evidence for post-translational processing.

1991 • 29 citations

Nerve Growth Factor Stimulates the Production of Inositol 1,3,4‐and 1,4,5‐Trisphosphate and Inositol 1,3,4,5‐Tetrakisphosphate in PC 12 Cells

1993 • 8 citations