The CATH Dictionary of Homologous Superfamilies (DHS): a consensus approach for identifying distant structural homologues

Gapped BLAST and PSI-BLAST: a new generation of protein database search programs

1997 • 71,835 citations

Dictionary of protein secondary structure: Pattern recognition of hydrogen‐bonded and geometrical features

1983 • 14,802 citations

MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures

1991 • 14,222 citations

A general method applicable to the search for similarities in the amino acid sequence of two proteins

1970 • 11,049 citations

LIGPLOT: a program to generate schematic diagrams of protein-ligand interactions

1995 • 5,246 citations

Protein Structure Comparison by Alignment of Distance Matrices

1993 • 3,989 citations

[26] Raster3D: Photorealistic molecular graphics

1997 • 3,784 citations

The SWISS-PROT protein sequence data bank and its supplement TrEMBL in 1999

1999 • 3,156 citations

RASMOL: biomolecular graphics for all

1995 • 2,601 citations

CATH – a hierarchic classification of protein domain structures

1997 • 2,558 citations

Twilight zone of protein sequence alignments

1999 • 1,691 citations

Database of homology‐derived protein structures and the structural meaning of sequence alignment

1991 • 1,641 citations

The PROSITE database, its status in 1999

1999 • 1,109 citations

GenTHREADER: an efficient and reliable protein fold recognition method for genomic sequences

1999 • 901 citations

Protein superfamilles and domain superfolds

1994 • 779 citations

Protein structure alignment

1989 • 683 citations

Multiple protein sequence alignment from tertiary structure comparison: Assignment of global and residue confidence levels

1992 • 655 citations

PRINCIPLES THAT DETERMINE THE STRUCTURE OF PROTEINS

1984 • 645 citations

PDBsum: a web-based database of summaries and analyses of all PDB structures

1997 • 596 citations

Sequence comparisons using multiple sequences detect three times as many remote homologues as pairwise methods

1998 • 560 citations

Assessing sequence comparison methods with reliable structurally identified distant evolutionary relationships

1998 • 532 citations

Pfam 3.1: 1313 multiple alignments and profile HMMs match the majority of proteins

1999 • 511 citations

HOMSTRAD: A database of protein structure alignments for homologous families

1998 • 505 citations

GenBank

1999 • 479 citations

JOY: protein sequence-structure representation and analysis.

1998 • 390 citations

Structure, evolution and action of vitamin B6-dependent enzymes

1998 • 388 citations

SMART: identification and annotation of domains from signalling and extracellular protein sequences

1999 • 325 citations

Predicting functions from protein sequences—where are the bottlenecks?

1998 • 311 citations

Enzyme Nomenclature. Recommendations 1992

1994 • 247 citations

Structural classification of proteins: new superfamilies

1996 • 240 citations

How far divergent evolution goes in proteins

1998 • 236 citations

Intermediate sequences increase the detection of homology between sequences

1997 • 225 citations

Protein folds and functions

1998 • 217 citations

Tertiary structural constraints on protein evolutionary diversity: templates, key residues and structure prediction

1990 • 215 citations

Protein folds and families: sequence and structure alignments

1999 • 201 citations

Recognition of analogous and homologous protein folds: analysis of sequence and structure conservation 1 1Edited by F. E. Cohen

1997 • 197 citations

Comparison of solvent-inaccessible cores of homologous proteins: definitions useful for protein modelling

1987 • 196 citations

Assigning genomic sequences to CATH

2000 • 192 citations

A systematic comparison of protein structure classifications: SCOP, CATH and FSSP

1999 • 189 citations

SCOP: a Structural Classification of Proteins database

1999 • 183 citations

The CATH Database provides insights into protein structure/function relationships

1999 • 179 citations

Population statistics of protein structures: lessons from structural classifications

1997 • 168 citations

Recent improvements of the ProDom database of protein domain families

1999 • 166 citations

Fast structure alignment for protein databank searching

1992 • 140 citations

PRINTS prepares for the new millennium

1999 • 129 citations

Evolution of protein function, from a structural perspective

1999 • 116 citations

Classification of protein folds

1994 • 113 citations

Sequences annotated by structure: a tool to facilitate the use of structural information in sequence analysis

1998 • 106 citations

[37] Understanding protein structure: Using scop for fold interpretation

1996 • 103 citations

An automatic method involving cluster analysis of secondary structures for the identification of domains in proteins

1995 • 89 citations

Three-dimensional structure analysis of PROSITE patterns 1 1Edited by F. E. Cohen

1999 • 89 citations

Correlation of observed fold frequency with the occurrence of local structural motifs

1999 • 80 citations

CAMPASS: a database of structurally aligned protein superfamilies

1998 • 70 citations

A dynamic look at structures: WWW-entrez and the molecular modeling database

1996 • 65 citations

An atlas of protein topology cartoons available on the world-wide web

1998 • 64 citations

A database of globular protein structural domains: clustering of representative family members into similar folds

1996 • 63 citations

CORA—Topological fingerprints for protein structural families

1999 • 63 citations

Residual colours: a proposal for aminochromography

1997 • 62 citations

Identification of homologous core structures

1999 • 59 citations

A protein structure comparison methodology

1996 • 56 citations

Combining sensitive database searches with multiple intermediates to detect distant homologues

1999 • 52 citations

The ENZYME data bank in 1999

1999 • 43 citations

Taking a Structured Approach to Understanding Proteins

1998 • 36 citations

LPFC: An internet library of protein family core structures

1997 • 35 citations

MMDB: Entrez's 3D structure database

1999 • 35 citations

Genome analysis: Assigning protein coding regions to three‐dimensional structures

1999 • 34 citations

Common structural elements in the architecture of the cofactor-binding domains in unrelated families of pyridoxal phosphate-dependent enzymes

1999 • 32 citations

DOMPLOT: a program to generate schematic diagrams of the structural domain organization within proteins, annotated by ligand contacts

1999 • 11 citations