THE LUPUS ANTICOAGULANT/ANTIPHOSPHOLIPID SYNDROME

The Management of Thrombosis in the Antiphospholipid-Antibody Syndrome

1995 • 1,467 citations

Antiphospholipid Thrombosis: Clinical Course after the First Thrombotic Event in 70 Patients

1992 • 702 citations

Lupus Anticoagulant IgG's (LA) Are Not Directed to Phospholipids only, but to a Complex of Lipid-Bound Human Prothrombin

1991 • 583 citations

Anticardiolipin antibodies recognize beta 2-glycoprotein I structure altered by interacting with an oxygen modified solid phase surface.

1994 • 535 citations

Anticardiolipin Antibodies and the Risk for Ischemic Stroke and Venous Thrombosis

1992 • 528 citations

Antiphospholipid antibodies directed against a combination of phospholipids with prothrombin, protein C, or protein S: an explanation for their pathogenic mechanism? [see comments]

1993 • 496 citations

Immunology and Clinical Importance of Antiphospholipid Antibodies

1991 • 490 citations

Induction of anti-phospholipid syndrome in naive mice with mouse lupus monoclonal and human polyclonal anti-cardiolipin antibodies.

1991 • 464 citations

Pregnancy: An informative protocol for the investigation of recurrent miscarriage: preliminary experience of 500 consecutive cases

1994 • 420 citations

Autoantibodies to phospholipid-binding plasma proteins: a new view of lupus anticoagulants and other "antiphospholipid" autoantibodies [see comments]

1994 • 364 citations

ANTIBODIES TO CARDIOLIPIN IN YOUNG SURVIVORS OF MYOCARDIAL INFARCTION: AN ASSOCIATION WITH RECURRENT CARDIOVASCULAR EVENTS

1986 • 361 citations

"Anticardiolipin" autoantibodies recognize beta 2-glycoprotein I in the absence of phospholipid. Importance of Ag density and bivalent binding.

1995 • 337 citations

Heterogeneity of anticardiolipin antibodies defined by the anticardiolipin cofactor.

1992 • 333 citations

Autoantibodies to phospholipid-binding plasma proteins: a new view of lupus anticoagulants and other "antiphospholipid" autoantibodies [see comments]

1994 • 317 citations

Anti-Cardiolipin Antibodies and Risk of Myocardial Infarction in a Prospective Cohort of Middle-Aged Men

1995 • 306 citations

Induction of primary antiphospholipid syndrome in mice by immunization with a human monoclonal anticardiolipin antibody (H-3).

1992 • 297 citations

Prevalence, Follow-Up and Clinical Significance of the Anticardiolipin Antibodies in Normal Subjects

1994 • 277 citations

Association of anti-β2 glycoprotein I antibodies with lupus-type circulating anticoagulant and thrombosis in systemic lupus erythematosus

1992 • 267 citations

A Phospholipid-β2-Glycoprotein I Complex Is an Antigen for Anticardiolipin Antibodies Occurring in Autoimmune Disease But Not with Infection

1992 • 262 citations

Patients with antiphospholipid antibodies and venous thrombosis should receive long term anticoagulant treatment.

1993 • 241 citations

Reduction of annexin-V (placental anticoagulant protein-I) on placental villi of women with antiphos pholipid antibodies and recurrent spontaneous abortion

1994 • 237 citations

Inhibition of activated protein C and its cofactor protein S by antiphospholipid antibodies

1990 • 216 citations

Induction of antiphospholipid autoantibodies by immunization with beta 2 glycoprotein I (apolipoprotein H).

1992 • 211 citations

Lupus anticoagulant activity of autoimmune antiphospholipid antibodies is dependent upon beta 2-glycoprotein I.

1992 • 206 citations

Prevalence of lupus anticoagulant and anticardiolipin antibodies in a healthy population

1990 • 200 citations

Induction of tissue factor-like activity in monocytes by anti-cardiolipin antibodies.

1994 • 199 citations

Immunization with Anticardiolipin Cofactor (Beta-2-Glycoprotein I) Induces Experimental Antiphospholipid Syndrome in Naive Mice

1994 • 194 citations

Association between antiphospholipid antibodies and cardiac abnormalities in patients with systemic lupus erythematosus

1990 • 192 citations

Measurement of anti-phospholipid antibodies by ELISA using β2-glycoprotein I as an antigen

1991 • 191 citations

Transverse myelitis: a manifestation of systemic lupus erythematosus strongly associated with antiphospholipid antibodies.

1990 • 187 citations

Immunology: High fecundity rates following in− vitro fertilization and embryo transfer in antiphospholipid antibody seropositive women treated with heparin and aspirin

1994 • 187 citations

Anticoagulant Activity of β2-Glycoprotein I Is Potentiated by a Distinct Subgroup of Anticardiolipin Antibodies

1992 • 183 citations

Impaired catalytic function of activated protein C: a new in vitro manifestation of lupus anticoagulant

1989 • 178 citations

Heparin therapy for pregnant women with lupus anticoagulant or anticardiolipin antibodies

1991 • 170 citations

Anti β2 glycoprotein I antibodies: detection and association with thrombosis

1995 • 169 citations

Prevalence and clinical significance of elevated antiphospholipid antibodies in patients with idiopathic thrombocytopenic purpura

1994 • 163 citations

Multicenter evaluation of nine commercial kits for the quantitation of anticardiolipin antibodies. The Working Group on Methodologies in Haemostasis from the GEHT (Groupe d'Etudes sur l'Hémostase et la Thrombose).

1995 • 153 citations

Beta 2-glycoprotein I is a requirement for anticardiolipin antibodies binding to activated platelets: differences with lupus anticoagulants

1993 • 151 citations

Kaolin clotting time and dilute Russell's viper venom time distinguish between prothrombin-dependent and beta 2-glycoprotein I-dependent antiphospholipid antibodies

1995 • 148 citations

β₂‐Glycoprotein i reactivity of monoclonal anticardiolipin antibodies from patients with the antiphospholipid syndrome

1994 • 146 citations

The expression of the placental anticoagulant protein, annexin V, by villous trophoblasts: Immunolocalization and in vitro regulation

1994 • 141 citations

Coagulation screen is more specific than the anticardiolipin antibody ELISA in defining a thrombotic subset of lupus patients.

1988 • 141 citations

Monoclonal antiphospholipid antibody reactivity against human placental trophoblast

1992 • 141 citations

Effect of Human IgG Antiphospholipid Antibodies on an In Vivo Thrombosis Model in Mice

1994 • 141 citations

Antiphospholipid Antibodies Enhance Thrombin-Induced Platelet Activation and Thromboxane Formation

1993 • 140 citations

Autoantibodies to phosphatidylethanolamine (PE) recognize a kininogen- PE complex

1995 • 135 citations

Autoimmune Antiphospholipid Antibodies Are Directed against a Cryptic Epitope Expressed when β2-Glycoprotein I Is Bound to a Suitable Surface

1995 • 134 citations

Should anticardiolipin tests be performed in otherwise healthy pregnant women?

1991 • 133 citations

Prevention of fetal loss in experimental antiphospholipid syndrome by in vivo administration of recombinant interleukin-3.

1993 • 133 citations

On the role of phosphatidylethanolamine in the inhibition of activated protein C activity by antiphospholipid antibodies.

1995 • 132 citations

Cardiac involvement in patients with primary antiphospholipid syndrome

1991 • 131 citations

Antiphospholipid-protein antibodies: Laboratory detection and clinical relevance

1995 • 131 citations

Functional and binding studies of the roles of prothrombin and beta 2- glycoprotein I in the expression of lupus anticoagulant activity

1994 • 130 citations

Autoantibodies to heparin from patients with antiphospholipid antibody syndrome inhibit formation of antithrombin III-thrombin complexes [see comments]

1994 • 130 citations

Imbalance of thromboxane/prostacyclin biosynthesis in patients with lupus anticoagulant

1991 • 127 citations

Beta 2 glycoprotein I and placental anticoagulant protein I in placentae from patients with antiphospholipid syndrome.

1994 • 121 citations

Antibodies to endothelial cells in systemic lupus erythematosus: a potential marker for nephritis and vasculitis

1991 • 119 citations

Multicenter Evaluation of Nine Commercial Kits for the Quantitation of Anticardiolipin Antibodies

1995 • 118 citations

Clinical consequences of antiphospholipid antibodies: an historic cohort study.

1994 • 115 citations

Anticardiolipin antibodies block the inhibition by beta 2-glycoprotein I of the factor Xa generating activity of platelets.

1993 • 115 citations

β2-Glycoprotein I Deficiency and the Risk of Thrombosis

1992 • 114 citations

Anticardiolipin antibodies in an unselected stroke population

1994 • 109 citations

Influence of the antiphospholipid syndrome in the survival of patients with systemic lupus erythematosus.

1994 • 107 citations

Epitope specificity of monoclonal anti-beta 2-glycoprotein I antibodies derived from patients with the antiphospholipid syndrome.

1995 • 103 citations

Anticardiolipin antibodies in Sneddon's syndrome

1990 • 99 citations

Detection of endothelial cell‐reactive immunoglobulin in patients with anti‐phospholipid antibodies

1991 • 99 citations

High Prevalence of Antiphospholipid Antibodies in Children With Idiopathic Cerebral Ischemia

1994 • 97 citations

Accuracy of Anticardiolipin Antibodies in Identifying a History of Thrombosis Among Patients With Systemic Lupus Erythematosus

1995 • 93 citations

Thrombosis in systemic lupus erythematosus: a French collaborative study.

1991 • 93 citations

Clinical significance of β2-glycoprotein I-dependent anticardiolipin antibodies in the reproductive autoimmune failure syndrome: Correlation with conventional antiphospholipid antibody detection systems

1995 • 92 citations

Platelet Activating Properties of Murine Monoclonal Antibodies to β2-Glycoprotein I

1993 • 92 citations

Anticardiolipin Antibodies Block the Inhibition by β2-Glycoprotein I of the Factor Xa Generating Activity of Platelets

1993 • 91 citations

β₂‐glycoprotein 1 (β₂GP1) enhances cardiolipin binding activity but is not the antigen for antiphospholipid antibodies

1992 • 90 citations

The Immunobiology and Obstetrical Consequences of Antiphospholipid Antibodies

1994 • 89 citations

Effect of antiphospholipid antibodies on procoagulant activity of activated platelets and platelet‐derived microvesicles

1993 • 89 citations

IgG anti-cardiolipin antibodies in murine lupus.

1989 • 88 citations

Immunoglobulin Fractions Isolated from Patients with Antiphospholipid Antibodies Prevent the Inactivation of Factor Va by Activated Protein C on Human Endothelial Cells

1992 • 85 citations

Should anticardiolipin tests be performed in otherwise healthy pregnant women?

1991 • 84 citations

Antiphospholipid syndrome associated with immunotherapy for patients with melanoma.

1995 • 81 citations

Acquired free protein S deficiency is associated with antiphospholipid antibodies and increased thrombin generation in patients with systemic lupus erythematosus

1995 • 79 citations

Increased thrombin generation and activity in patients with systemic lupus erythematosus and anticardiolipin antibodies: evidence for a prothrombotic state [see comments]

1993 • 79 citations

Exposure of Anionic Phospholipids upon Platelet Activation Permits Binding of β2 Glycoprotein I and Through it that ofIgG Antiphospholipid Antibodies. Studies in Platelets from Patients with Antiphospholipid Syndrome and Normal Subjects

1994 • 78 citations

Induction of experimental anti-phospholipid syndrome associated with SLE following immunization with human monoclonal pathogenic anti-DNA idiotype

1992 • 78 citations

Antiphospholipid syndrome associated with immunotherapy for patients with melanoma

1994 • 77 citations

Anticardiolipin Antibodies in Infections are Heterogenous in Their Dependency on β 2-Glycoprotein I: Analysis of Anticardiolipin Antibodies in Leprosy

1994 • 76 citations

Antiphospholipid Antibody Positive Sera Enhance Endothelial Cell Procoagulant Activity – Studies in a Thrombosis Model

1992 • 76 citations

Antibody to phosphatidylethanolamine in a patient with lupus anticoagulant and thrombosis.

1989 • 75 citations

The prevalence of lupus anticoagulant and anticardiolipin antibodies in women with a history of first trimester miscarriages

1994 • 73 citations

Lupus Anticoagulant Autoantibody Induces Apoptosis in Umbilical Vein Endothelial Cells: Involvement of Annexin V

1994 • 72 citations

The thrombotic diathesis associated with the presence of phospholipid antibodies may be due to low levels of free protein S

1992 • 70 citations

Relationship between anti-phospholipid and anti-endothelial cell antibodies: further characterization of the reactivity on resting and cytokine-activated endothelial cells.

1992 • 69 citations

Lupus anticoagulant inhibition of in Vitro prostacyclin release is associated with a thrombosis-prone subset of patients

1991 • 69 citations

Prevalence, Significance, and Specificity of Antibodies to Phospholipids in Q Fever

1994 • 69 citations

Changes in β2-Glycoprotein I Antigenicity Induced by Phospholipid Binding

1993 • 67 citations

Antiendothelial cell antibodies and their relation to pulmonary hypertension in systemic lupus erythematosus.

1994 • 64 citations

Autoimmune MRL-1 pr/1pr mice are an animal model for the secondary antiphospholipid syndrome.

1990 • 63 citations

Risk factors for thrombosis in lupus patients.

1989 • 62 citations

Anti-idiotypes Against Antiphospholipid Antibodies are present in Normal Polyspecific Immunoglobulins for Therapeutic Use

1994 • 61 citations

Pregnancy in Systemic Lupus Erythematosus: a Prospective Study

1994 • 61 citations

Antibodies to platelets in patients with anti-phospholipid antibodies

1991 • 61 citations

Antiphosphatidylethanolamine antibody as the sole antiphospholipid antibody in systemic lupus erythematosus with thrombosis.

1992 • 60 citations

Anti-endothelial cell antibodies in sera of patients with autoimmune diseases: comparison between ELISA and FACS analysis

1994 • 57 citations

Inhibition of heparin/antithrombin III cofactor activity by anticardiolipin antibodies: A mechanism for thrombosis

1993 • 57 citations

Antiphospholipid antibodies and the antiphospholipid syndrome

1994 • 57 citations

Lupus Anticoagulant and Cardiac Manifestations in Systemic Lupus Erythematosus

1994 • 56 citations

Correlation of antiphospholipid antibodies and protein S deficiency with thrombosis in HIV-infected men.

1994 • 55 citations

Some ‘antiphospholipid antibodies’ bind to β₂‐glycoprotein I in the absence of phospholipid

1992 • 54 citations

High-Dose Intravenous Immunoglobulin Treatment of a Pregnant Patient with an Antiphospholipid Syndrome: Immunological Changes Associated with a Successful Outcome

1994 • 54 citations

Antiphospholipid antibodies and thrombotic predisposition: underlying pathogenetic mechanisms [editorial; comment]

1994 • 54 citations

Lupus‐like anticoagulant properties of murine monoclonal antibodies to β₂‐glycoprotein I

1992 • 53 citations

A new variant of interaction between phospholipid antibodies and the protein C system

1994 • 52 citations

High levels of anti-phospholipid antibodies in uncomplicated and severePlasmodium falciparumand inP. vivaxmalaria

1994 • 50 citations

The development of antiphospholipid antibodies in haemophilia is linked to infection with hepatitis C

1994 • 50 citations

Antiphospholipid Antibodies, Haemostatic Variables and Thrombosis – A Survey of 144 Patients

1995 • 50 citations

Studies on phospholipid antibodies, APC-resistance and associated mutation in the coagulation factor V gene

1995 • 50 citations

Specific antiplatelet autoantibodies in patients with antiphospholipid antibodies and thrombocytopenia

1994 • 50 citations

Use of a generally applicable tissue factor--dependent factor V assay to detect activated protein C-resistant factor Va in patients receiving warfarin and in patients with a lupus anticoagulant

1995 • 49 citations

Characteristics of human immunodeficiency virus and chlorpromazine induced antiphospholipid antibodies: effect of beta 2 glycoprotein I on binding to phospholipid.

1994 • 47 citations

Detection of antitrophoblast antibodies in the sera of patients with anticardiolipin antibodies and fetal loss

1993 • 44 citations

Evaluation of Recently Described Tests for Detection of the Lupus Anticoagulant

1994 • 43 citations

Immunization of a rabbit with beta 2-glycoprotein I induces charge-dependent crossreactive antibodies that bind anionic phospholipids and have similar reactivity as autoimmune anti-phospholipid antibodies.

1995 • 40 citations

Clinicopathologic correlations of antiphospholipid antibodies. An autopsy study.

1994 • 38 citations

Increased immunoglobulin binding to cerebral endothelium in patients with antiphospholipid antibodies.

1993 • 37 citations

Increased Monocyte Procoagulant Activity Independent of the Lupus Anticoagulant in Patients with Systemic Lupus Erythematosus

1990 • 36 citations

Suppression of experimental antiphospholipid syndrome and systemic lupus erythematosus in mice by anti‐CD4 monoclonal antibodies

1994 • 35 citations

Anti‐CD36 antibodies in patients with lupus anticoagulant and thrombotic complications

1994 • 34 citations

Prevalence of Valvular Involvement in Systemic Lupus erythematosus and Association with Antiphospholipid Syndrome: A Matched Echocardiographic Study

1994 • 32 citations

Enhancement of thrombin-thrombomodulin-catalysed protein C activation by phosphatidylethanolamine containing unsaturated fatty acids: possible physiological significance of phosphatidylethanolamine in anticoagulant activity of thrombomodulin

1994 • 32 citations

Inhibition of prothrombin activation by antiphospholipid antibodies and β₂‐glycoprotein 1

1994 • 32 citations

Antiphospholipid Antibodies in Patients with Idiopathic Autoimmune Haemolytic Anemia

1994 • 31 citations

Acquired protein C dysfunction but not decreased activity of thrombomodulin is a possible marker of thrombophilia in patients with lupus anticoagulant.

1995 • 30 citations

Effect of Long-Acting Thromboxane Receptor Antagonist (BMS 180,291) on Experimental Antiphospholipid Syndrome

1994 • 30 citations

INHIBITION OF PROSTACYCLIN RELEASE BY ENDOTHELIAL BINDING ANTICARDIOLIPIN ANTIBODIES IN THROMBOSIS-PRONE PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS AND THE ANTIPHOSPHOLIPID SYNDROME

1994 • 29 citations

The anticardiolipin antibody in elderly stroke patients: its effects on stroke types, recurrence, and the coagulation-fibrinolysis system

2009 • 29 citations

Increased activated protein C-protein C inhibitor complex level in patients positive for lupus anticoagulant

1994 • 28 citations

Antiphospholipid Antibodies and Platelets

1995 • 28 citations

Antiphospholipid antibodies and risk of intrauterine late fetal death

1994 • 28 citations

The Lupus Anticoagulant-Hypoprothrombinemia Syndrome

1994 • 28 citations

Antinuclear and Antiphospholipid Antibodies in Healthy Women With Recurrent Spontaneous Abortion

1994 • 27 citations

Lupus anticoagulant and increased thrombin generation in patients with systemic lupus erythematosus [letter; comment]

1994 • 26 citations

Clinical analysis of 125 patients with the lupus anticoagulant

1993 • 26 citations

Poor Pregnancy Outcome and Anticardiolipin Antibodies

1994 • 25 citations

Monoclonal hybridoma anti-cardiolipin antibodies from SLE mice.

1988 • 25 citations

Elution of anticardiolipin antibodies and their cofactor β2-glycoprotein 1 from the placentae of patients with a poor obstetric history

1993 • 25 citations

Platelet autoantibodies detected by immunoblotting in systemic lupus erythematosus: Association with the lupus anticoagulant, and with history of thrombosis and thrombocytopenia

1990 • 25 citations

Evaluation of the clinical and laboratory associations of antiphosphatidylethanolamine antibodies

1990 • 24 citations

Transient lupus anticoagulant associated with prothrombin deficiency: unusual cause of bleeding in a 5-year-old girl.

1994 • 24 citations

Clinical and Therapeutic Aspects Associated to Phospholipid Binding Antibodies (Lupus Anticoagulant and Anticardiolipin Antibodies)

1994 • 24 citations

Antibodies to Phosphatidylethanolamine in Antiphospholipid Syndrome and Systemic Lupus Erythematosus: Their Correlation with Anticardiolipin Antibodies and P₂Glycoprotein-I Plasma Levels

1993 • 24 citations

Effect of Plasma from Patients with Primary Antiphospholipid Syndrome on Platelet Function in a Collagen Rich Perfusion System

1995 • 22 citations

Antibodies to beta 2-glycoprotein I inhibit phospholipid dependent coagulation reactions.

1993 • 22 citations

Antiendothelial Cell Antibodies in Systemic Lupus erythematosus: Enhanced Antibody Binding to lnterleukin-1-Stimulated Endothelium

1994 • 21 citations

Effective induction of anti-phospholipid and anticoagulant antibodies in normal mouse

1991 • 21 citations

Standardization of Immunoassays for Antiphospholipid Antibodies with β2GPI and Role of Other Phospholipid Cofactors

1994 • 20 citations

Differences in protein S and C4b-binding protein levels in different groups of patients with antiphospholipid antibodies.

1994 • 20 citations

Anticardiolipin antibodies in pediatric patients with human immunodeficiency virus.

1994 • 19 citations

Lupus anticoagulant and increased thrombin generation in patients with systemic lupus erythematosus [letter; comment]

1994 • 19 citations

Immunology: β2-Glycoprotein I-dependent and -independent anticardiolipin antibodies in healthy pregnant women

1994 • 18 citations

Some recent developments with lupus anticoagulants

1994 • 18 citations

New Diagnostic Strategies for Lupus Anticoagulants and Antiphospholipid Antibodies

1994 • 18 citations

Antibodies to β2-Glycoprotein I Inhibit Phospholipid Dependent Coagulation Reactions

1993 • 17 citations

Antiphospholipid antibodies in a healthy population: methods for estimating the distribution.

1995 • 17 citations

Plasma reactivity to hexagonal II phase phosphatidylethanolamine is more frequently associated with lupus anticoagulant than with antiphosphatidylethanolamine antibodies.

1993 • 17 citations

Establishment of two distinct anti-cardiolipin antibody-producing cell lines from the same individual by Ebstein-Barr virus transformation

1994 • 16 citations

Hemostatic System Activation in Patients with Lupus Anticoagulant and Essential Thrombocythemia

1994 • 16 citations

Anticardiolipin Antibodies in Patients with Unstable Angina

1994 • 14 citations

Sneddon's syndrome and antiphospholipid antibodies

1993 • 13 citations

Role of IL-3 in the Antiphospholipid Syndrome

1994 • 12 citations

Heterogeneity and Diversity of IgM and IgG Lupus Anticoagulants in an Individual with Systemic Lupus Erythematosus

1994 • 11 citations

β₂‐GPI‐dependent and independent binding of anticardiolipin antibodies in patients with recurrent spontaneous abortions

1994 • 11 citations

Plasma concentrations of total/free and functional protein S are not decreased in systemic lupus erythematosus patients with lupus anticoagulant and/or antiphospholipid antibodies

1994 • 10 citations

Experimental Models for Antiphospholipid Studies

1994 • 10 citations

Detection of Beta-2-Glycoprotein-l-Dependent Antiphospholipid Antibodies and Anti-Beta-2-Glyco-protein-l Antibody in Patients with Systemic Lupus Erythematosus and in Patients with Syphilis

1994 • 8 citations

Sneddon's syndrome: clinical and immunohistochemical findings

1994 • 6 citations

The significance of experimental models of systemic lupus erythematosus and antiphospholipid syndrome induced by idiotypic manipulation.

1994 • 5 citations

The effect of sera with antiphospholipid antibodies on endothelial cell procoagulant activity is dependent upon the charge of the phospholipids against which they are directed

1994 • 5 citations

Crossreactivity of anti-cardiolipin antibodies with glycolipids and endothelial cells.

1994 • 3 citations

New basic aspects of the antiphospholipid syndrome.

1994 • 3 citations

Endothelial Cell 1-acyl-platelet-activating factor synthesis in response to anticardiolipin antibody-positive serum fractions

1994 • 3 citations

A human monoclonal IgA autoantibody—185/12—behaves like an autoimmune antiphospholipid antibody

1994 • 3 citations