Antiphospholipid-protein antibodies: Laboratory detection and clinical relevance

Anti-phospholipid antibodies are directed against a complex antigen that includes a lipid-binding inhibitor of coagulation: beta 2-glycoprotein I (apolipoprotein H).

1990 • 1,618 citations

ANTICARDIOLIPIN ANTIBODIES: DETECTION BY RADIOIMMUNOASSAY AND ASSOCIATION WITH THROMBOSIS IN SYSTEMIC LUPUS ERYTHEMATOSUS

1983 • 1,413 citations

Anticardiolipin antibodies (ACA) directed not to cardiolipin but to a plasma protein cofactor

1990 • 1,294 citations

Venous thrombosis due to poor anticoagulant response to activated protein C: Leiden Thrombophilia Study

1993 • 1,283 citations

Antiphospholipid Antibodies: Anticardiolipin and the Lupus Anticoagulant in Systemic Lupus Erythematosus (SLE) and in Non-SLE Disorders

1990 • 1,093 citations

The "primary" antiphospholipid syndrome: major clinical and serological features.

1989 • 909 citations

Evaluation of the anti-cardiolipin antibody test: report of an international workshop held 4 April 1986.

1987 • 722 citations

Antiphospholipid Thrombosis: Clinical Course after the First Thrombotic Event in 70 Patients

1992 • 702 citations

Use of Antithrombotic Agents During Pregnancy

1995 • 682 citations

The antiphospholipid syndrome: ten years on

1993 • 640 citations

Antibody to Cardiolipin as a Predictor of Fetal Distress or Death in Pregnant Patients with Systemic Lupus Erythematosus

1985 • 594 citations

Repeated fetal losses associated with antiphospholipid antibodies: A collaborative randomized trial comparing prednisone with low-dose heparin treatment

1992 • 594 citations

Lupus Anticoagulant IgG's (LA) Are Not Directed to Phospholipids only, but to a Complex of Lipid-Bound Human Prothrombin

1991 • 583 citations

ARTERIAL THROMBOSIS, INTRAUTERINE DEATH AND "LUPUS" ANTICOAGULANT: DETECTION OF IMMUNOGLOBULIN INTERFERING WITH PROSTACYCLIN FORMATION

1981 • 558 citations

Measurement of anti-cardiolipin antibodies by an enzyme-linked immunosorbent assay (ELISA): standardization and quantitation of results.

1985 • 554 citations

Anticardiolipin antibodies recognize beta 2-glycoprotein I structure altered by interacting with an oxygen modified solid phase surface.

1994 • 535 citations

Acquired inhibitors of blood coagulation.

1972 • 531 citations

Anticardiolipin Antibodies and the Risk for Ischemic Stroke and Venous Thrombosis

1992 • 528 citations

THROMBOSIS IN SYSTEMIC LUPUS ERYTHEMATOSUS DESPITE CIRCULATING ANTICOAGULANTS.

1963 • 524 citations

Thrombosis in systemic lupus erythematosus: striking association with the presence of circulating lupus anticoagulant.

1983 • 518 citations

Antiphospholipid antibodies directed against a combination of phospholipids with prothrombin, protein C, or protein S: an explanation for their pathogenic mechanism? [see comments]

1993 • 496 citations

A clinical study of the lupus anticoagulant

1976 • 478 citations

The use of the dilute Russell viper venom time for the diagnosis of lupus anticoagulants

1986 • 427 citations

The Second International Anti-Cardiolipin Standardization Workshop/The Kingston Anti-Phospholipid Antibody Study (KAPS) Group

1990 • 420 citations

SYNDROME OF THE BLACK SWAN

1987 • 404 citations

A Sensitive Test Demonstrating Lupus Anticoagulant and its Behavioural Patterns

1978 • 401 citations

Immune Endothelial-Cell Injury in Heparin-Associated Thrombocytopenia

1987 • 390 citations

beta 2-Glycoprotein I: a plasma inhibitor of the contact activation of the intrinsic blood coagulation pathway

1985 • 364 citations

Autoantibodies to phospholipid-binding plasma proteins: a new view of lupus anticoagulants and other "antiphospholipid" autoantibodies [see comments]

1994 • 364 citations

SI CHAOS

1976 • 363 citations

Eine serodiagnostische Reaktion bei Syphilis

1906 • 362 citations

ANTIBODIES TO CARDIOLIPIN IN YOUNG SURVIVORS OF MYOCARDIAL INFARCTION: AN ASSOCIATION WITH RECURRENT CARDIOVASCULAR EVENTS

1986 • 361 citations

Primary Antiphospholipid Syndrome

2020 • 354 citations

Heterogeneity of anticardiolipin antibodies defined by the anticardiolipin cofactor.

1992 • 333 citations

Immunoglobulin G fractions from patients with antiphospholipid antibodies cause fetal death in BALB/c mice: A model for autoimmune fetal loss

1990 • 320 citations

Autoantibodies to phospholipid-binding plasma proteins: a new view of lupus anticoagulants and other "antiphospholipid" autoantibodies [see comments]

1994 • 317 citations

BIOLOGICALLY FALSE POSITIVE SEROLOGIC TESTS FOR SYPHILIS

1952 • 315 citations

Induction of primary antiphospholipid syndrome in mice by immunization with a human monoclonal anticardiolipin antibody (H-3).

1992 • 297 citations

The protein C anticoagulant pathway.

1992 • 293 citations

Laboratory Diagnosis of Lupus Inhibitors: A Comparison of the Tissue Thromboplastin Inhibition Procedure with a New Platelet Neutralization Procedure

1983 • 285 citations

Cerebrovascular and neurologic disease associated with antiphospholipid antibodies

1990 • 283 citations

Anti-prothrombin antibodies and the lupus anticoagulant

1988 • 255 citations

The Relationship Between Lupus Anticoagulants and Antibodies to Phospholipid

1988 • 254 citations

A New Serologically Active Phospholipid from Beef Heart

1941 • 251 citations

Antiphospholipid antibodies and cerebral ischemia in young people

1990 • 250 citations

Guidelines for testing and revised criteria for lupus anticoagulants. SSC Subcommittee for the Standardization of Lupus Anticoagulants.

1991 • 249 citations

Patients with antiphospholipid antibodies and venous thrombosis should receive long term anticoagulant treatment.

1993 • 241 citations

ANTIPHOSPHOLIPID ANTIBODIES

1990 • 225 citations

Anticardiolipin antibodies in autoimmune thrombocytopenic purpura

1985 • 220 citations

A mechanism for the hypoprothrombinemia of the acquired hypoprothrombinemia-lupus anticoagulant syndrome

1983 • 214 citations

The natural history of systemic lupus erythematosus: An approach to its study through chronic biologic false positive reactors

1955 • 197 citations

Guidelines for Testing and Revised Criteria for Lupus Anticoagulants

1991 • 192 citations

Measurement of anti-phospholipid antibodies by ELISA using β2-glycoprotein I as an antigen

1991 • 191 citations

Anticardiolipin antibodies in NZW x BXSB F1 mice. A model of antiphospholipid syndrome.

1992 • 185 citations

Association between antiphospholipid antibodies and epilepsy in patients with systemic lupus erythematosus

1994 • 184 citations

Anticoagulant Activity of β2-Glycoprotein I Is Potentiated by a Distinct Subgroup of Anticardiolipin Antibodies

1992 • 183 citations

Impaired catalytic function of activated protein C: a new in vitro manifestation of lupus anticoagulant

1989 • 178 citations

Clinical and laboratory findings in patients with antiphospholipid antibodies and cerebral ischemia. The Antiphospholipid Antibodies in Stroke Study Group.

1990 • 176 citations

Lupus anticoagulant activity is frequently dependent on the presence of beta 2-glycoprotein I.

1992 • 175 citations

Heparin therapy for pregnant women with lupus anticoagulant or anticardiolipin antibodies

1991 • 170 citations

Inherited predisposition to thrombosis

1993 • 166 citations

Hypergammaglobulinemia, circulating anticoagulant, and biologic false positive Wassermann reaction; a study in two cases.

1957 • 163 citations

Antiphospholipid Antibodies and Recurrent Pregnancy Loss

1989 • 163 citations

Fetal loss in systemic lupus: association with anticardiolipin antibodies

1985 • 156 citations

�ber ein bisher unbekanntes niedermolekulares ?2-Glubulin des Humanserums

1961 • 152 citations

CORONARY ARTERY BYPASS GRAFT FAILURE—AN AUTOIMMUNE PHENOMENON?

1986 • 150 citations

β₂‐Glycoprotein i reactivity of monoclonal anticardiolipin antibodies from patients with the antiphospholipid syndrome

1994 • 146 citations

Anti‐annexin V antibody in systemic lupus erythematosus patients with lupus anticoagulant and/or anticardiolipin antibody

1994 • 145 citations

Lupus Anticoagulant Activity Is Frequently Dependent on the Presence of β2-Glycoprotein I

1992 • 142 citations

Effect of Human IgG Antiphospholipid Antibodies on an In Vivo Thrombosis Model in Mice

1994 • 141 citations

Antiphospholipid Antibodies Enhance Thrombin-Induced Platelet Activation and Thromboxane Formation

1993 • 140 citations

Amino acid sequence and location of the disulfide bonds in bovine .beta.2 glycoprotein I: the presence of five Sushi domains

1991 • 138 citations

Antiphospholipid antibodies after myocardial infarction and their relation to mortality, reinfarction, and non-haemorrhagic stroke

1992 • 131 citations

Autoantibodies to heparin from patients with antiphospholipid antibody syndrome inhibit formation of antithrombin III-thrombin complexes [see comments]

1994 • 130 citations

Prothrombin as Co-Factor of the Circulating Anticoagulant in Systemic Lupus Erythematosus?

1959 • 130 citations

A Hexagonal (II) Phase Phospholipid Neutralization Assay for Lupus Anticoagulant Identification

1993 • 129 citations

Imbalance of thromboxane/prostacyclin biosynthesis in patients with lupus anticoagulant

1991 • 127 citations

Report of the Working Party on Acquired Inhibitors of Coagulation: Studies of the “Lupus” Anticoagulant

1983 • 120 citations

Antiphospholipid antibodies and thrombosis. A consequence, coincidence, or cause?

1993 • 119 citations

Anticardiolipin Wet Workshop Report:Fifth International Symposium on Antiphospholipid Antibodies

1994 • 117 citations

Chlorpromazine‐induced anticardiolipin antibodies and lupus anticoagulant: Absence of thrombosis

1988 • 116 citations

Anticardiolipin antibodies block the inhibition by beta 2-glycoprotein I of the factor Xa generating activity of platelets.

1993 • 115 citations

β2-Glycoprotein I Deficiency and the Risk of Thrombosis

1992 • 114 citations

'Primary', 'Secondary' and Other Variants of the Antiphospholipid Syndrome

1994 • 114 citations

Acquired inhibitors of blood cagulation

1972 • 112 citations

Distinguishing Plasma Lupus Anticoagulants from Anti-Factor Antibodies Using Hexagonal (II) Phase Phospholipids

1989 • 111 citations

The Varied Sensitivity of Partial Thromboplastin and Prothrombin Time Reagents in the Demonstration of the Lupus‐Like Anticoagulant

1979 • 108 citations

The Textarin/Ecarin Ratio: A Confirmatory Test for Lupus Anticoagulants

1993 • 108 citations

Lupus anticoagulants: misnomer, paradox, riddle, epiphenomenon.

1988 • 101 citations

Inherited Resistance to Activated Protein C, a Major Cause of Venous Thrombosis, is due to a Mutation in the Factor V Gene

1994 • 97 citations

Activity, disulphate mapping and structural modelling of the fifth domain of human β₂ -glycoprotein I

1992 • 96 citations

beta 2-Glycoprotein I. Molecular properties of an unusual apolipoprotein, apolipoprotein H.

1983 • 93 citations

The Diagnosis of Lupus Anticoagulants by the Activated Partial Thromboplastin Time - The Central Role of Phosphatidyl Serine

1984 • 93 citations

Anticardiolipin Antibodies Block the Inhibition by β2-Glycoprotein I of the Factor Xa Generating Activity of Platelets

1993 • 91 citations

Abnormal prothrombin crossed-immunoelectrophoresis in patients with lupus inhibitors

1984 • 90 citations

Acquired hypoprothrombinemia due to non-neutralizing antibodies to prothrombin: mechanism and management

1985 • 89 citations

Beta2-Glycoprotein I

1994 • 87 citations

Prevention of anticardiolipin antibody-related pregnancy losses with prednisone and aspirin

1992 • 85 citations

Separation of anticardiolipin antibodies from lupus anticoagulant on a phospholipid-coated polystyrene column

1988 • 83 citations

Increased thrombin generation and activity in patients with systemic lupus erythematosus and anticardiolipin antibodies: evidence for a prothrombotic state [see comments]

1993 • 79 citations

Anti-glycoprotein Ib/IX and IIb/IIIa antibodies in patients with antiphospholipid antibodies.

1994 • 76 citations

Lupus anticoagulants: improved diagnosis with a kaolin clotting time using rabbit brain phospholipid in standard and high concentrations

1986 • 75 citations

Lupus anticoagulant and antiplatelet properties of human hybridoma autoantibodies.

1987 • 75 citations

Evaluation of lupus anticoagulants: Antiphospholipid antibodies, endothelium associated immunoglobulin, endothelial prostacyclin secretion, and antigenic protein S levels

1988 • 75 citations

Lupus anticoagulant induces a selective defect in thrombin‐mediated endothelial prostacyclin release and platelet aggregation

1989 • 75 citations

Lupus anticoagulant inhibition of in Vitro prostacyclin release is associated with a thrombosis-prone subset of patients

1991 • 69 citations

Anti-Glycoprotein Ib/IX and llb/llla Antibodies in Patients with Antiphospholipid Antibodies

1994 • 68 citations

Primary antiphospholipid syndrome

1990 • 66 citations

Guidelines on testing for the lupus anticoagulant. Lupus Anticoagulant Working Party on behalf of the BCSH Haemostasis and Thrombosis Task Force.

1991 • 65 citations

Comparison of Two Simple Tests for the Lupus Anticoagulant

1985 • 65 citations

Transient lupus anticoagulant associated with hypoprothrombinemia and Factor XII deficiency following adenovirus infection

1993 • 65 citations

Autoimmune MRL-1 pr/1pr mice are an animal model for the secondary antiphospholipid syndrome.

1990 • 63 citations

Chorea gravidarum associated with circulating lupus anticoagulant: successful outcome of pregnancy with prednisone and aspirin therapy. Case report

1983 • 62 citations

Risk factors for thrombosis in lupus patients.

1989 • 62 citations

The Role of Antiphospholipid Antibodies in Stroke

1992 • 62 citations

Antibodies to platelets in patients with anti-phospholipid antibodies

1991 • 61 citations

Genetic studies on the deficiency of �2-glycoprotein I of human serum

1968 • 61 citations

Antiphospholipid Antibodies in Vascular Surgery Patients A Cross-Sectional Study

1994 • 60 citations

Anticardiolipin Antibody and Stroke: Possible Relation of Valvular Heart Disease and Embolic Events

1991 • 58 citations

Lupus Anticoagulant and Cardiac Manifestations in Systemic Lupus Erythematosus

1994 • 56 citations

Correction of hypoprothrombinemia by immunosuppressive treatment of the lupus anticoagulant-hypoprothrombinemia syndrome

1987 • 53 citations

Lupus anticoagulant: a clinical and laboratory study of 100 cases

1988 • 53 citations

A hemorrhagic disorder caused by circulating anticoagulants in patients with disseminated lupus erythematosus

1952 • 52 citations

Clinical manifestations of the antiphospholipid syndrome.

1992 • 52 citations

Molecular Studies on Phospholipid-Binding Sites and Cryptic Epitopes Appearing on β₂-Glycoprotein I Structure Recognized by Anticardiolipin Antibodies

1995 • 49 citations

Use of Antithrombotic Agents During Pregnancy

1992 • 49 citations

Transient lupus anticoagulant induced by Epstein-Barr virus infection

1991 • 49 citations

Thrombosis and Antiphospholipid Syndrome: a Preliminary Assessment of Three Antithrombotic Treatments

1994 • 49 citations

The relationship between lupus anticoagulants and antibodies to phospholipid

1988 • 48 citations

In Vitro Studies of Antiphospholipid Antibodies and Its Cofactor, β2-Glycoprotein I, Show Negligible Effects on Endothelial Cell Mediated Protein C Activation

1991 • 46 citations

Evaluation of Different Mixing Study Reagents and Dilution Effect in Lupus Anticoagulant Testing

1991 • 46 citations

COLLAGEN DISEASE AND THE CHRONIC BIOLOGICAL FALSE POSITIVE PHENOMENON

1961 • 42 citations

Production of thromboxane and prostaglandins in human blood in the presence of thromboxane synthase inhibitors

1991 • 42 citations

Some antiphospholipid antibodies inhibit phospholipase A2 activity.

1992 • 40 citations

Assays for Detection of Antiphospholipid Antibodies

1994 • 39 citations

Observations on the characteristics of an unusual circulating anticoagulant.

1951 • 38 citations

Clinicopathologic correlations of antiphospholipid antibodies. An autopsy study.

1994 • 38 citations

Preparation of plasma for the detection of lupus anticoagulants and antiphospholipid antibodies

1992 • 36 citations

Time Dependency of Lupuslike Anticoagulants

1988 • 35 citations

Effect of lupus anticoagulants on the activated partial thromboplastin time. Results of the College of American Pathologists survey program.

1991 • 35 citations

Prevention and induction of occlusive coronary vascular disease in autoimmune (W/B)F1 mice by haploidentical bone marrow transplantation: possible role for anticardiolipin autoantibodies

1993 • 35 citations

Biologic False-Positive Reaction for Syphilis

1963 • 35 citations

Isolation and characterization of TextarinR, a prothrombin activator from eastern brown snake (Pseudonaja textilis) venom

1994 • 35 citations

Heat treatment of serum and plasma induces false positive results in the antiphospholipid antibody ELISA.

1990 • 34 citations

Detection of Antiphospholipid Antibodies by Flow Cytometry: Rapid Detection of Antibody Isotype and Phospholipid Specificity

1993 • 31 citations

Distinguishing β₂‐glycoprotein I dependent (systemic lupus erythematosus type) and independent (syphilis type) anticardiolipin antibody with Tween 20

1993 • 30 citations

A new lupus anticoagulant neutralization test based on platelet‐derived vesicles

1992 • 30 citations

The effect of phospholipid on the detection of lupus anticoagulants by the dilute Russell viper venom time.

1989 • 30 citations

Budd-Chiari syndrome in a young patient with anticardiolipin antibodies: need for prolonged anticoagulant treatment.

1994 • 29 citations

Presence of serum antibodies to coagulation protein C in patients with systemic lupus erythematosus is not associated with antigenic or functional protein c deficiencies

1993 • 29 citations

The Lupus Anticoagulant-Hypoprothrombinemia Syndrome

1994 • 28 citations

Characterization and antigenic specificity of chlorpromazine-induced antinuclear antibodies.

1986 • 26 citations

Rapid preparation of plasma for 'Stat' coagulation testing.

1994 • 26 citations

Autoantibodies to Thrombomodulin: Development of an Enzyme Immunoassay and a Survey of their Frequency in Patients with the Lupus Anticoagulant

1992 • 26 citations

Clinical analysis of 125 patients with the lupus anticoagulant

1993 • 26 citations

Childhood stroke and lupus anticoagulant

1994 • 26 citations

Pyoderma-gangraenosum-Like Ulcers Associated with Lupus Anticoagulant

1994 • 25 citations

Clinical manifestations of the antiphospholipid syndrome

1992 • 25 citations

Comparison Between a One-Point Dilute Phospholipid APTT and the Dilute Russell Viper Venom Time for Verification of Lupus Anticoagulants

1992 • 25 citations

Screening for the lupus anticoagulant

1989 • 25 citations

The Role of IVIG in the Management of Patients with Antiphospholipid Antibodies and Recurrent Pregnancy Losses

1992 • 25 citations

Comparison of a Standardized Procedure with Current Laboratory Practices for the Detection of Lupus Anticoagulant in France

1993 • 23 citations

Protein S antibodies in acquired protein S deficiencies [letter]

1994 • 23 citations

The lupus anticoagulant stimulates the release of prostacyclin from human endothelial cells

1988 • 23 citations

ACQUIRED HYPOPROTHROMBINAEMIA AND LUPUS ANTICOAGULANT: RESPONSE TO STEROID THERAPY

1991 • 22 citations

Prothrombin-antibody coexistent with lupus anticoagulant (LA): Clinical study and immunochemical characterization

1990 • 22 citations

Anticardiolipin Antibodies in a Sample of Chronic Schizophrenics Receiving Neuroleptic Therapy

1994 • 20 citations

Platelet antibodies in immune thrombocytopenia

1992 • 19 citations

Anticardiolipin antibody determination: comparison of three ELISA assays.

1990 • 19 citations

Antiphospholipid Syndrome Within Systemic Lupus Erythematosus

1994 • 18 citations

New Diagnostic Strategies for Lupus Anticoagulants and Antiphospholipid Antibodies

1994 • 18 citations

Laboratory heterogeneity of the lupus anticoagulant : A multicentre study using different clotting assays on a panel of 78 samples

1992 • 17 citations

Anticardiolipm Antibodies: Specificity and Function

1994 • 17 citations

Protein S antibodies in acquired protein S deficiencies.

1994 • 17 citations

The lupus anticoagulant and eicosanoids

1993 • 16 citations

Study of antiphospholipid antibodies in a patient with Sneddon's syndrome and her family.

1994 • 16 citations

Naturally Occurring Species Specific Inhibitor of Human Prothrombin in Lupus Erythematosus.

1964 • 15 citations

Antiphospholipid antibodies

1994 • 15 citations

Behavior of Diluted Activated Partial Thromboplastin Time in Pregnant Women with a Lupus Anticoagulant

1993 • 12 citations

Antiphospholipid Antibodies Eicosanoids

1994 • 10 citations

Use of the Agarose Gel Method to Identify and Quantitate Factor VIII:C Inhibitors

1985 • 10 citations

Experimental Models for Antiphospholipid Studies

1994 • 10 citations

Disseminated Intravascular Coagulation in a Patient with Systemic Lupus Erythematosus with Lupus Anticoagulant.

1993 • 9 citations

Ivig Therapy Today

1992 • 9 citations

Intracardiac Thrombosis and Antiphospholipid Antibodies

1994 • 9 citations

Hepatic and splenic haemorrhage as a complication of toxaemia of pregnancy in a patient with circulating lupus anticoagulant.

1982 • 8 citations

Time dependency of lupuslike anticoagulants

1988 • 8 citations

Species specificity of lupus-like anticoagulants

1986 • 6 citations

The Annexins

1994 • 6 citations

Correction of Clotting Factor “Deficiencies” in Plasma from Patients with Lupus-Like Anticoagulants

1984 • 5 citations

Anticardiolipin and acquired protein S deficiency in early childhood

1994 • 5 citations

Detection of Lupus Anticoagulants and Anticardiolipin Antibodies - Prevalence of Positive Tests in 665 Patients

1993 • 2 citations

Diagnosis of Lupus Anticoagulants

1994 • 1 citations