Gene therapy for collateral vessel development

Signal transduction by receptors with tyrosine kinase activity

1990 • 5,528 citations

Lipofection: a highly efficient, lipid-mediated DNA-transfection procedure.

1987 • 4,937 citations

Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis

1992 • 4,631 citations

Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice

1995 • 3,977 citations

Requisite Role of Angiopoietin-1, a Ligand for the TIE2 Receptor, during Embryonic Angiogenesis

1996 • 2,844 citations

Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium

1995 • 2,650 citations

Mechanism of activation of the TGF-β receptor

1994 • 2,298 citations

Vascular endothelial growth factor is a potential tumour angiogenesis factor in human gliomas in vivo

1992 • 2,293 citations

The fms -Like Tyrosine Kinase, a Receptor for Vascular Endothelial Growth Factor

1992 • 2,042 citations

Isolation of Angiopoietin-1, a Ligand for the TIE2 Receptor, by Secretion-Trap Expression Cloning

1996 • 1,969 citations

High affinity VEGF binding and developmental expression suggest Flk-1 as a major regulator of vasculogenesis and angiogenesis

1993 • 1,961 citations

THE HEPARIN-BINDING (FIBROBLAST) GROWTH FACTOR FAMILY OF PROTEINS

1989 • 1,948 citations

A novel vascular endothelial growth factor, VEGF-C, is a ligand for the Flt4 (VEGFR-3) and KDR (VEGFR-2) receptor tyrosine kinases.

1996 • 1,670 citations

Molecular and Biological Properties of the Vascular Endothelial Growth Factor Family of Proteins

1992 • 1,612 citations

The Vascular Endothelial Growth Factor Family: Identification of a Fourth Molecular Species and Characterization of Alternative Splicing of RNA

1991 • 1,375 citations

The heart and cardiovascular system

1986 • 1,333 citations

The Fgf Family of Growth Factors and Oncogenes

1992 • 1,164 citations

Expression of vascular endothelial growth factor during embryonic angiogenesis and endothelial cell differentiation

1992 • 1,103 citations

Therapeutic angiogenesis. A single intraarterial bolus of vascular endothelial growth factor augments revascularization in a rabbit ischemic hind limb model.

1994 • 1,058 citations

Transfer of Genes to Humans: Early Lessons and Obstacles to Success

1995 • 1,023 citations

Nucleotide sequence and expression of a novel human receptor-type tyrosine kinase gene (flt) closely related to the fms family.

1990 • 982 citations

Clinical evidence of angiogenesis after arterial gene transfer of phVEGF165 in patient with ischaemic limb

1996 • 980 citations

Structure and function of small arteries

1990 • 902 citations

Potent synergism between vascular endothelial growth factor and basic fibroblast growth factor in the induction of angiogenesis in vitro

1992 • 865 citations

Vascular Dysmorphogenesis Caused by an Activating Mutation in the Receptor Tyrosine Kinase TIE2

1996 • 779 citations

Cloning and expression of two distinct high-affinity receptors cross-reacting with acidic and basic fibroblast growth factors.

1990 • 635 citations

Angiogenic-induced enhancement of collateral blood flow to ischemic myocardium by vascular endothelial growth factor in dogs.

1994 • 616 citations

Synergistic Effect of Vascular Endothelial Growth Factor and Basic Fibroblast Growth Factor on Angiogenesis In Vivo

1995 • 605 citations

Increased gene expression for VEGF and the VEGF receptors KDR/Flk and Flt in lungs exposed to acute or to chronic hypoxia. Modulation of gene expression by nitric oxide.

1995 • 590 citations

A cytosolic herpes simplex virus protein inhibits antigen presentation to CD8+ T lymphocytes

1994 • 553 citations

Hemodynamic forces are complex regulators of endothelial gene expression

1995 • 547 citations

Identification of a new endothelial cell growth factor receptor tyrosine kinase

1991 • 529 citations

Salvage of Infarcted Myocardium by Angiogenic Action of Basic Fibroblast Growth Factor

1992 • 519 citations

The receptor tyrosine kinase TIE is required for integrity and survival of vascular endothelial cells.

1995 • 517 citations

Meeting Highlights

1996 • 497 citations

Intracoronary gene transfer of fibroblast growth factor–5 increases blood flow and contractile function in an ischemic region of the heart

1996 • 484 citations

Regulation of growth factor activation by proteoglycans: What is the role of the low affinity receptors?

1995 • 478 citations

Nonviral Gene Therapy: The Promise of Genes as Pharmaceutical Products

1995 • 471 citations

Tie-1 and tie-2 define another class of putative receptor tyrosine kinase genes expressed in early embryonic vascular system.

1993 • 470 citations

Synergistic effects of vascular endothelial growth factor and basic fibroblast growth factor on the proliferation and cord formation of bovine capillary endothelial cells within collagen gels.

1993 • 463 citations

Molecular mechanisms of angiogenesis: fibroblast growth factor signal transduction

1995 • 461 citations

Stabilization of Vascular Endothelial Growth Factor mRNA by Hypoxia and Hypoglycemia and Coregulation with Other Ischemia-Induced Genes

1995 • 453 citations

Complexity of FGF receptors: genetic basis for structural diversity and functional specificity

1992 • 441 citations

Targeted gene delivery by tropism-modified adenoviral vectors

1996 • 431 citations

Vascular endothelial growth factor-related protein: a ligand and specific activator of the tyrosine kinase receptor Flt4.

1996 • 406 citations

Direct Intramuscular Gene Transfer of Naked DNA Encoding Vascular Endothelial Growth Factor Augments Collateral Development and Tissue Perfusion

1996 • 396 citations

Generation of recombinant adenovirus vectors with modified fibers for altering viral tropism

1996 • 392 citations

Molecular Cloning of a Novel Cytokine cDNA Encoding the Ninth Member of the Fibroblast Growth Factor Family, which has a Unique Secretion Property

1993 • 390 citations

Comparative Effects of Basic Fibroblast Growth Factor and Vascular Endothelial Growth Factor on Coronary Collateral Development and the Arterial Response to Injury

1996 • 383 citations

Molecular Mechanisms of Coronary Collateral Vessel Growth

1996 • 377 citations

The fibroblast growth factor family: Structural and biological properties

1989 • 362 citations

Hypoxia-induced paracrine regulation of vascular endothelial growth factor receptor expression.

1996 • 351 citations

VEGF, flk-1, and flt-1 expression in a rat myocardial infarction model of angiogenesis

1996 • 342 citations

Adenovirus targeted to heparan-containing receptors increases its gene delivery efficiency to multiple cell types

1996 • 327 citations

Macrophage-derived angiogenesis factors

1991 • 325 citations

Vascular permeability factor: A unique regulator of blood vessel function

1991 • 322 citations

Angiogenesis in ischemic heart disease

1997 • 322 citations

Keratinocyte growth factor

1995 • 321 citations

Immunotherapy of malignancy by in vivo gene transfer into tumors.

1993 • 320 citations

Hypoxia Is a Strong Inducer of Vascular Endothelial Growth Factor mRNA Expression in the Heart

1993 • 308 citations

Basic fibroblast growth factor enhances myocardial collateral flow in a canine model

1994 • 304 citations

Targeted adenovirus gene transfer to endothelial and smooth muscle cells by using bispecific antibodies

1996 • 293 citations

Vascular endothelial growth factor administration in chronic myocardial ischemia

1996 • 246 citations

Effects of Chronic Systemic Administration of Basic Fibroblast Growth Factor on Collateral Development in the Canine Heart

1995 • 245 citations

Growth inhibition of human melanoma cells in nude mice by antisense strategies to the type 1 insulin-like growth factor receptor.

1994 • 234 citations

Gene Transfer with a Series of Lipophilic DNA-Binding Molecules

1994 • 219 citations

Arterial Gene Therapy for Therapeutic Angiogenesis in Patients With Peripheral Artery Disease

1995 • 216 citations

Rapid induction of vascular endothelial growth factor expression by transient ischemia in rat heart

1994 • 215 citations

Gene transfer of naked DNA encoding for three isoforms of vascular endothelial growth factor stimulates collateral development in vivo.

1996 • 215 citations

Intramuscular administration of vascular endothelial growth factor induces dose-dependent collateral artery augmentation in a rabbit model of chronic limb ischemia.

1994 • 214 citations

Prolonged Transgene Expression in Cotton Rat Lung with Recombinant Adenoviruses Defective in E2a

1994 • 212 citations

Site-specific therapeutic angiogenesis after systemic administration of vascular endothelial growth factor

1995 • 205 citations

Fibroblast growth factors and their receptors: An information network controlling tissue growth, morphogenesis and repair

1994 • 195 citations

Controlling the vasculature: Angiogenesis, anti-angiogenesis and vascular targeting of gene therapy

1995 • 194 citations

Importance of collateral circulation for prevention of left ventricular aneurysm formation in acute myocardial infarction.

1989 • 180 citations

A gene transfer vector-cell line system for complete functional complementation of adenovirus early regions E1 and E4

1996 • 177 citations

A new superfamily of cell surface proteins related to the nerve growth factor receptor

1991 • 172 citations

Safety and Short-Term Toxicity of a Novel Cationic Lipid Formulation for Human Gene Therapy

1993 • 171 citations

Therapeutic Angiogenesis Following Arterial Gene Transfer of Vascular Endothelial Growth Factor in a Rabbit Model of Hindlimb Ischemia

1996 • 170 citations

VEGF ₁₆₅ Expressed by a Replication-Deficient Recombinant Adenovirus Vector Induces Angiogenesis In Vivo

1995 • 159 citations

Angiogenesis: an update.

1994 • 157 citations

Acidic Fibroblast Growth Factor Enhances Peripheral Nerve Regeneration in Vivo

1989 • 157 citations

Arterial Gene Transfer Using Pure DNA Applied Directly to a Hydrogel-Coated Angioplasty Balloon

1993 • 150 citations

Aortic Smooth Muscle Cells Express and Secrete Vascular Endothelial Growth Factor

1991 • 148 citations

Cell autonomous functions of the receptor tyrosine kinase TIE in a late phase of angiogenic capillary growth and endothelial cell survival during murine development

1996 • 145 citations

Transcriptional Regulation by Hypoxia-Inducible Factor 1 Molecular Mechanisms of Oxygen Homeostasis

1996 • 139 citations

Effects of acidic fibroblast growth factor on normal and ischemic myocardium.

1991 • 139 citations

Enhanced revascularization of the ischemic limb by angiogenic therapy.

1993 • 134 citations

Characterization of an Adenovirus Gene Transfer Vector Containing an E4 Deletion

1995 • 133 citations

Development of Cell Lines Capable of Complementing E1, E4, and Protein IX Defective Adenovirus Type 5 Mutants

1995 • 131 citations

Capillary growth in chronically stimulated adult skeletal muscle as studied by intravital microscopy and histological methods in rabbits and rats

1978 • 128 citations

Efficient dual transcomplementation of adenovirus E1 and E4 regions from a 293-derived cell line expressing a minimal E4 functional unit

1996 • 125 citations

Genetic modification of the vessel wall. Comparison of surgical and catheter-based techniques for delivery of recombinant adenovirus.

1994 • 122 citations

Enhanced microvascular relaxations to VEGF and bFGF in chronically ischemic porcine myocardium

1996 • 119 citations

Diverse receptors for fibroblast growth factors

1992 • 119 citations

Nasal application of the cationic liposome DC-Chol:DOPE does not alter ion transport, lung function or bacterial growth

1994 • 108 citations

Low-efficiency of percutaneous adenovirus-mediated arterial gene transfer in the atherosclerotic rabbit.

1995 • 106 citations

Comparative analysis of adenovirus fiber-cell interaction: adenovirus type 2 (Ad2) and Ad9 utilize the same cellular fiber receptor but use different binding strategies for attachment

1996 • 98 citations

Mechanisms of tumor necrosis factor action.

1992 • 97 citations

Cyclic amphipathic peptide-DNA complexes mediate high-efficiency transfection of adherent mammalian cells.

1993 • 95 citations

Improvement of treadmill capacity and collateral circulation as a result of exercise with heparin pretreatment in patients with effort angina.

1988 • 95 citations

Targeted Delivery of DNA Using YEE(GalNAcAH)3, a Synthetic Glycopeptide Ligand for the Asialoglycoprotein Receptor

1994 • 94 citations

Capillary growth: a two-cell system.

1992 • 85 citations

The constitutive expression of the immunomodulatory gp19k protein in E1-, E3- adenoviral vectors strongly reduces the host cytotoxic T cell response against the vector.

1995 • 85 citations

The Insulin-like Growth Factors and the Lung

1990 • 85 citations

A packaging cell line for propagation of recombinant adenovirus vectors containing two lethal gene-region deletions.

1995 • 81 citations

In Vivo Angiogenesis Induced by Recombinant Adenovirus Vectors Coding Either for Secreted or Nonsecreted Forms of Acidic Fibroblast Growth Factor

1995 • 78 citations

Enhancement of angiogenesis by bFGF in mandibular bone graft healing in the rabbit

1988 • 78 citations

Expression of Vascular Endothelial Growth Factor From a Defective Herpes Simplex Virus Type 1 Amplicon Vector Induces Angiogenesis in Mice

1995 • 71 citations

Strategies for targeted gene therapy

1996 • 69 citations

Basic FGF enhances endothelium-dependent relaxation of the collateral-perfused coronary microcirculation

1994 • 69 citations

Effect of Basic Fibroblast Growth Factor on Myocardial Angiogenesis in Dogs With Mature Collateral Vessels

1997 • 67 citations

bFGF enhances the development of the collateral circulation after acute arterial occlusion

1992 • 63 citations

Heparin promotes the formation of extracardiac to coronary anastomoses in a canine model

1991 • 59 citations

Angiogenic effects of low molecular weight heparin in patients with stable coronary artery disease: A pilot study

1993 • 52 citations

A New Cationic Liposome Encapsulating Genetic Material

1995 • 48 citations

Heparin Increases Exercise-Induced Collateral Blood Flow in Rats With Femoral Artery Ligation

1995 • 44 citations

Expression cloning, developmental expression and chromosomal localization of fibroblast growth factor-8.

1995 • 43 citations

Role of basic fibroblast growth factor in revascularization of rabbit tracheal autografts

1991 • 39 citations

Comparison of the neovascular effects of stimulated macrophages and neutrophils in autologous rabbit corneas.

1985 • 37 citations

De novo generation of permanent neovascularized soft tissue appendages by platelet-derived growth factor.

1994 • 32 citations

Temporal and spatial expression of lipospermine-compacted genes transferred into chick embryos in vivo.

1994 • 32 citations

Group C Adenoviruses as Vectors for Gene Therapy

1995 • 30 citations

Efficacy of Low-Molecular-Weight Heparin in the Management of Intermittent Claudication

1991 • 28 citations

Two additional protein-tyrosine kinases expressed in human lung: fourth member of the fibroblast growth factor receptor family and an intracellular protein-tyrosine kinase.

1991 • 27 citations

Retro-Vectors for Human Gene Therapy

1996 • 8 citations