PI3K Pathway Activation Mediates Resistance to MEK Inhibitors in KRAS Mutant Cancers

Mutations of the BRAF gene in human cancer

2002 • 10,249 citations

Targeting RAS signalling pathways in cancer therapy

2003 • 3,105 citations

New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway

1999 • 1,972 citations

Ras, PI(3)K and mTOR signalling controls tumour cell growth

2006 • 1,934 citations

Phosphatidylinositol-3-OH kinase direct target of Ras

1994 • 1,923 citations

PI3K pathway alterations in cancer: variations on a theme

2008 • 1,752 citations

A Functional Genetic Approach Identifies the PI3K Pathway as a Major Determinant of Trastuzumab Resistance in Breast Cancer

2007 • 1,562 citations

BRAF mutation predicts sensitivity to MEK inhibition

2005 • 1,312 citations

Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers

2008 • 1,306 citations

Beyond PTEN mutations: the PI3K pathway as an integrator of multiple inputs during tumorigenesis

2006 • 1,210 citations

PTEN and the PI3-Kinase Pathway in Cancer

2008 • 1,154 citations

Targeting the mitogen-activated protein kinase cascade to treat cancer

2004 • 1,093 citations

BRAF and RAS mutations in human lung cancer and melanoma.

2002 • 979 citations

Mutant PIK3CA promotes cell growth and invasion of human cancer cells

2005 • 873 citations

P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase

1997 • 778 citations

Constitutive activation of the 41-/43-kDa mitogen-activated protein kinase signaling pathway in human tumors

1999 • 688 citations

Essential roles of PI(3)K–p110β in cell growth, metabolism and tumorigenesis

2008 • 659 citations

Altered Growth of Human Colon Cancer Cell Lines Disrupted at Activated Ki- ras

1993 • 627 citations

Binding of Ras to Phosphoinositide 3-Kinase p110α Is Required for Ras- Driven Tumorigenesis in Mice

2007 • 560 citations

Mutations in a signalling pathway

2005 • 551 citations

PTEN-deficient cancers depend on PIK3CB

2008 • 513 citations

Single-vector inducible lentiviral RNAi system for oncology target validation

2009 • 414 citations

Targeting AKT/mTOR and ERK MAPK signaling inhibits hormone-refractory prostate cancer in a preclinical mouse model

2008 • 392 citations

The prevalence of PIK3CA mutations in gastric and colon cancer

2005 • 333 citations

Renewing the conspiracy theory debate: does Raf function alone to mediate Ras oncogenesis?

2004 • 299 citations

Analysis of BRAF and N-RAS mutations in metastatic melanoma tissues.

2003 • 215 citations

PIK3CA Cooperates with Other Phosphatidylinositol 3′-Kinase Pathway Mutations to Effect Oncogenic Transformation

2008 • 178 citations

Advances in the Development of Cancer Therapeutics Directed against the RAS-Mitogen-Activated Protein Kinase Pathway

2008 • 164 citations

Response and determinants of cancer cell susceptibility to PI3K inhibitors: Combined targeting of PI3K and Mek1 as an effective anticancer strategy

2008 • 93 citations

RAS: Target for Cancer Therapy

2008 • 82 citations