Short-Term Effects of Particulate Matter: An Inflammatory Mechanism?

Atherosclerosis — An Inflammatory Disease

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Toxic Potential of Materials at the Nanolevel

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Inflammation in atherosclerosis

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Nanotoxicology: An Emerging Discipline Evolving from Studies of Ultrafine Particles

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Acute-Phase Proteins and Other Systemic Responses to Inflammation

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Health Effects of Fine Particulate Air Pollution: Lines that Connect

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Air pollution and health

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An Nrf2/Small Maf Heterodimer Mediates the Induction of Phase II Detoxifying Enzyme Genes through Antioxidant Response Elements

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Prostaglandins and Leukotrienes: Advances in Eicosanoid Biology

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Atherosclerosis

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Air Pollution and Cardiovascular Disease

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Growth of biological thought

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The Failing Heart — An Engine Out of Fuel

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Particulate air pollution and acute health effects

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Impact of Reduced Heart Rate Variability on Risk for Cardiac Events

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Passage of Inhaled Particles Into the Blood Circulation in Humans

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Air Pollution-Related Illness: Effects of Particles

2005 • 1,572 citations

Production of C-reactive protein and risk of coronary events in stable and unstable angina

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Ultrafine Particles Cross Cellular Membranes by Nonphagocytic Mechanisms in Lungs and in Cultured Cells

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Acute Phase Proteins with Special Reference to C-Reactive Protein and Related Proteins (Pentaxins) and Serum Amyloid A Protein

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Size-Dependent Proinflammatory Effects of Ultrafine Polystyrene Particles: A Role for Surface Area and Oxidative Stress in the Enhanced Activity of Ultrafines

2001 • 1,259 citations

Particulate matter in the atmosphere: which particle properties are important for its effects on health?

2000 • 1,098 citations

EXTRAPULMONARY TRANSLOCATION OF ULTRAFINE CARBON PARTICLES FOLLOWING WHOLE-BODY INHALATION EXPOSURE OF RATS

2002 • 1,063 citations

Chronic Obstructive Pulmonary Disease

2000 • 1,037 citations

Confounding and Effect Modification in the Short-Term Effects of Ambient Particles on Total Mortality: Results from 29 European Cities within the APHEA2 Project

2001 • 971 citations

TRANSLOCATION OF ULTRAFINE INSOLUBLE IRIDIUM PARTICLES FROM LUNG EPITHELIUM TO EXTRAPULMONARY ORGANS IS SIZE DEPENDENT BUT VERY LOW

2002 • 938 citations

The interactions between inflammation and coagulation

2005 • 923 citations

Exposure to Traffic and the Onset of Myocardial Infarction

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Acute Inflammatory Responses in the Airways and Peripheral Blood After Short-Term Exposure to Diesel Exhaust in Healthy Human Volunteers

1999 • 875 citations

Ambient Pollution and Heart Rate Variability

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The Relationship Between Reduced Lung Function and Cardiovascular Mortality

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Nitric oxide in immunity and inflammation

2001 • 839 citations

Inhalation of Fine Particulate Air Pollution and Ozone Causes Acute Arterial Vasoconstriction in Healthy Adults

2002 • 826 citations

C-Reactive Protein as a Cardiovascular Risk Factor

1999 • 824 citations

Relation of sputum inflammatory markers to symptoms and lung function changes in COPD exacerbations

2000 • 724 citations

Particulate air pollutants and asthma

2003 • 720 citations

Increased plasma viscosity during an air pollution episode: a link to mortality?

1997 • 718 citations

Pulmonary and systemic distribution of inhaled ultrafine silver particles in rats.

2001 • 675 citations

Acute Effects of Particulate Air Pollution on Respiratory Admissions

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Cytokines Involved in the Systemic Inflammatory Response Induced by Exposure to Particulate Matter Air Pollutants (PM₁₀)

2001 • 665 citations

Chemokines in pathology and medicine

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Harrison's Principles of Internal Medicine 16th ed

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Passage of Intratracheally Instilled Ultrafine Particles from the Lung into the Systemic Circulation in Hamster

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PM10 and PM2.5 source apportionment in the Barcelona Metropolitan area, Catalonia, Spain

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Mechanisms of macromolecule absorption by the lungs

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Apoptosis of vascular smooth muscle cells induces features of plaque vulnerability in atherosclerosis

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Ambient particle inhalation and the cardiovascular system: potential mechanisms.

2001 • 615 citations

Diesel Exhaust Inhalation Causes Vascular Dysfunction and Impaired Endogenous Fibrinolysis

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Increased 8-Isoprostane, a Marker of Oxidative Stress, in Exhaled Condensate of Asthma Patients

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Airway eosinophilia in chronic bronchitis during exacerbations.

1994 • 537 citations

Concentrated Ambient Air Particles Induce Mild Pulmonary Inflammation in Healthy Human Volunteers

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Ambient particulate air pollution, heart rate variability, and blood markers of inflammation in a panel of elderly subjects.

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Regulation of redox glutathione levels and gene transcription in lung inflammation: therapeutic approaches

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Short-term effects of particulate air pollution on cardiovascular diseases in eight European cities

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Daily variation of particulate air pollution and poor cardiac autonomic control in the elderly.

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Oxidative stress and calcium signaling in the adverse effects of environmental particles (PM10)

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Ultrafine Particle Deposition and Clearance in the Healthy and Obstructed Lung

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The Effects of Components of Fine Particulate Air Pollution on Mortality in California: Results from CALFINE

2006 • 422 citations

Temporal and spatial variations of PM2.5 and PM10 aerosol in the Southern California air quality study

1994 • 422 citations

Use of Proteomics to Demonstrate a Hierarchical Oxidative Stress Response to Diesel Exhaust Particle Chemicals in a Macrophage Cell Line

2003 • 421 citations

Oxidative stress in allergic respiratory diseases

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Particulate Air Pollution and Risk of ST-Segment Depression During Repeated Submaximal Exercise Tests Among Subjects With Coronary Heart Disease

2002 • 412 citations

Particulate air pollution and the blood

1999 • 405 citations

Ambient Particles and Health: Lines that Divide

1997 • 405 citations

Mechanisms of airway hyperresponsiveness

2006 • 401 citations

Air Pollution and Markers of Inflammation and Coagulation in Patients with Coronary Heart Disease

2005 • 400 citations

Particulate air pollution is associated with an acute phase response in men. Results from the MONICA–Augsburg Study

2001 • 399 citations

Macrophage Endocytosis of Superparamagnetic Iron Oxide Nanoparticles

2003 • 398 citations

Airborne particles are a risk factor for hospital admissions for heart and lung disease.

2000 • 393 citations

Inflammatory Lung Injury after Bronchial Instillation of Air Pollution Particles

2001 • 370 citations

Ultrafine Particle–Lung Interactions: Does Size Matter?

2006 • 366 citations

Air pollution and blood markers of cardiovascular risk.

2001 • 365 citations

Leukocyte and endothelial cell adhesion molecules as targets for therapeutic interventions in inflammatory disease

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Ultrafine Particles Affect Experimental Thrombosis in an In Vivo Hamster Model

2002 • 335 citations

Effect of glutathione-S-transferase M1 and P1 genotypes on xenobiotic enhancement of allergic responses: randomised, placebo-controlled crossover study

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Comparison of the Pro-Oxidative and Proinflammatory Effects of Organic Diesel Exhaust Particle Chemicals in Bronchial Epithelial Cells and Macrophages

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Ultrafine particle deposition in subjects with asthma.

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Acute Exposure to Diesel Exhaust Increases IL-8 and GRO- α Production in Healthy Human Airways

2000 • 326 citations

Change in size distribution and chemical composition of kosa (Asian dust) aerosol during long-range transport

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Cardiovascular Effects of Fine and Ultrafine Particles

2005 • 319 citations

Sources and processes affecting concentrations of PM10 and PM2.5 particulate matter in Birmingham (U.K.)

1997 • 318 citations

Effects of Ultrafine and Fine Particles in Urban Air on Peak Expiratory Flow among Children with Asthmatic Symptoms

1997 • 316 citations

Mechanisms in COPD

2000 • 308 citations

Impairment of Alveolar Macrophage Phagocytosis by Ultrafine Particles

2001 • 305 citations

Seasonal Variations in Air Pollution Particle-Induced Inflammatory Mediator Release and Oxidative Stress

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Ultrafine Particles in the Urban Air: To the Respiratory Tract--And Beyond?

2002 • 302 citations

Investigation of sources of atmospheric aerosol at urban and semi-urban areas in Bangladesh

2004 • 294 citations

Personal PM2.5 Exposure and Markers of Oxidative Stress in Blood

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Daily concentrations of air pollution and plasma fibrinogen in London

2000 • 286 citations

Human Alveolar Macrophage Responses to Air Pollution Particulates Are Associated with Insoluble Components of Coarse Material, Including Particulate Endotoxin

2001 • 286 citations

Increased asthma medication use in association with ambient fine and ultrafine particles

2002 • 284 citations

MEASUREMENT OF TOTAL LUNG DEPOSITION OF INHALED ULTRAFINE PARTICLES IN HEALTHY MEN AND WOMEN

2000 • 281 citations

The Human Bone Marrow Response to Acute Air Pollution Caused by Forest Fires

2000 • 281 citations

Genetic polymorphism of GSTM1 and antioxidant supplementation influence lung function in relation to ozone exposure in asthmatic children in Mexico City.

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Different airway inflammatory responses in asthmatic and healthy humans exposed to diesel

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Airway Inflammation after Controlled Exposure to Diesel Exhaust Particulates

2000 • 274 citations

Evidence for an Association Between Air Pollution and Daily Stroke Admissions in Kaohsiung, Taiwan

2003 • 273 citations

Ambient Air Pollution Is Associated With Increased Risk of Hospital Cardiac Readmissions of Myocardial Infarction Survivors in Five European Cities

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Metal-rich Ambient Particles (Particulate Matter_2.5) Cause Airway Inflammation in Healthy Subjects

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Activation of MAPKs in human bronchial epithelial cells exposed to metals

1998 • 259 citations

Airway antioxidant and inflammatory responses to diesel exhaust exposure in healthy humans

2006 • 254 citations

Association of Heart Rate Variability With Occupational and Environmental Exposure to Particulate Air Pollution

2001 • 254 citations

Particulate Matter Induces Cytokine Expression in Human Bronchial Epithelial Cells

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Increased inflammation and intracellular calcium caused by ultrafine carbon black is independent of transition metals or other soluble components

2000 • 248 citations

Endocytosis of Ultrafine Particles by A549 Cells

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Characterisation of chemical species in PM2.5 and PM10 aerosols in Brisbane, Australia

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Carbon in Airway Macrophages and Lung Function in Children

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An in vitro and in vivo investigation of the effects of diesel exhaust on human airway lining fluid antioxidants

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Effect of temperature on lung function and symptoms in chronic obstructive pulmonary disease

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Chemical composition of PM2.5 and PM10 in Mexico City during winter 1997

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Number concentration and size of particles in urban air: effects on spirometric lung function in adult asthmatic subjects.

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Pathways of clearance in mouse lungs exposed to iron oxide aerosols

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The Role of a Mitochondrial Pathway in the Induction of Apoptosis by Chemicals Extracted from Diesel Exhaust Particles

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Particulate Air Pollution and Hospital Admissions for Congestive Heart Failure in Seven United States Cities

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Diesel exhaust enhances airway responsiveness in asthmatic subjects

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RESPONSE OF HUMAN ALVEOLAR MACROPHAGES TO ULTRAFINE, FINE, AND COARSE URBAN AIR POLLUTION PARTICLES

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Air Pollution and Heart Rate Variability Among the Elderly in Mexico City

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Mass concentration and elemental composition of airborne particulate matter at street and background locations

1997 • 191 citations

Systemic Response to Ambient Particulate Matter: Relevance to Chronic Obstructive Pulmonary Disease

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Effects of aqueous extracts of PM₁₀filters from the Utah Valley on human airway epithelial cells

1999 • 184 citations

Particulate Matter Induces Alveolar Epithelial Cell DNA Damage and Apoptosis

2003 • 183 citations

Distribution Pattern of Inhaled Ultrafine Gold Particles in the Rat Lung

2006 • 181 citations

Diesel exhaust activates redox-sensitive transcription factors and kinases in human airways

2005 • 172 citations

Exposure to Concentrated Ambient Air Particles Alters Hematologic Indices in Humans

2003 • 172 citations

Controlled Exposures of Healthy and Asthmatic Volunteers to Concentrated Ambient Fine Particles in Los Angeles

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Particulate matter < 10 μm (PM10) and total suspended particulates (TSP) in urban, rural and alpine air in Switzerland

1995 • 161 citations

Elevated Concentrations of Exhaled Hydrogen Peroxide in Asthmatic Patients

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Effects of ultrafine carbon particle inhalation on allergic inflammation of the lung

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Identification and Substance P Content of Vagal Afferent Neurons Innervating the Epithelium of the Guinea Pig Trachea

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An investigation of the role of glutathione in increased epithelial permeability induced by cigarette smoke in vivo and in vitro.

1994 • 160 citations

Ambient endotoxin concentrations in PM10 from Southern California.

2004 • 159 citations

Effect of Particulate Air Pollution on Lung Function in Adult and Pediatric Subjects in a Seattle Panel Study

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Comparative receptor modelling study of airborne particulate pollutants in Birmingham (United Kingdom), Coimbra (Portugal) and Lahore (Pakistan)

1997 • 159 citations

Airway inflammation following exposure to diesel exhaust: a study of time kinetics using induced sputum

2000 • 156 citations

Robbins Basic Pathology - (2003)

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Increased Susceptibility to RSV Infection by Exposure to Inhaled Diesel Engine Emissions

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Ambient air pollution and acute myocardial infarction

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Pulmonary Function, Diffusing Capacity, and Inflammation in Healthy and Asthmatic Subjects Exposed to Ultrafine Particles

2004 • 146 citations

Associations between ambient air pollution and daily mortality among persons with diabetes and cardiovascular disease

2005 • 146 citations

Role of inflammation in cardiopulmonary health effects of PM

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Repolarization Changes Induced by Air Pollution in Ischemic Heart Disease Patients

2005 • 144 citations

Inhalation of Ultrafine Particles Alters Blood Leukocyte Expression of Adhesion Molecules in Humans

2005 • 144 citations

The Effect of Repeated Exposure to Particulate Air Pollution (PM₁₀) on the Bone Marrow

2001 • 143 citations

SYSTEMIC INFLAMMATORY RESPONSE INDUCED BY PARTICULATE MATTER AIR POLLUTION: THE IMPORTANCE OF BONE-MARROW STIMULATION

2002 • 141 citations

Respiratory Tract Deposition of Ultrafine Particles in Subjects with Obstructive or Restrictive Lung Disease

1990 • 138 citations

Phagocytosis of small carbon particles (PM10) by alveolar macrophages stimulates the release of polymorphonuclear leukocytes from bone marrow.

1997 • 135 citations

Concentrations of particulate airborne polycyclic aromatic hydrocarbons and metals collected in Lahore, Pakistan

1996 • 135 citations

Effects of exposure to ultrafine carbon particles in healthy subjects and subjects with asthma.

2004 • 133 citations

Effect of inhaled sulphur dioxide and carbon particles on heart rate variability and markers of inflammation and coagulation in human subjects

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Omega-3 Fatty Acid Prevents Heart Rate Variability Reductions Associated with Particulate Matter

2005 • 129 citations

Negligible clearance of ultrafine particles retained in healthy and affected human lungs

2006 • 122 citations

Serial measurements of exhaled nitric oxide during exacerbations of chronic obstructive pulmonary disease

1999 • 122 citations

The Relationship between Ambient Air Pollution and Heart Rate Variability Differs for Individuals with Heart and Pulmonary Disease

2005 • 120 citations

Coarse Particles and Heart Rate Variability among Older Adults with CoronaryArtery Disease in the Coachella Valley, California

2006 • 118 citations

No Significant Translocation of Inhaled 35-nm Carbon Particles to the Circulation in Humans

2006 • 118 citations

Dosimetric Comparisons of Particle Deposition and Retention in Rats and Humans

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Air pollution in asthma: effect of pollutants on airway inflammation

2001 • 110 citations

Inflammatory events in severe acute asthma

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Endothelial adhesion molecules in health and disease.

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The Role of Soluble Components in Ambient Fine Particles-Induced Changes in Human Lungs and Blood

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Exposure to welding fumes is associated with acute systemic inflammatory responses

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Relative Contributions of PM_2.5Chemical Constituents to Acute Arterial Vasoconstriction in Humans

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Seasonal evolution of suspended particles around a large coal-fired power station: Chemical characterization

1998 • 106 citations

Association between air pollution exposure and exhaled nitric oxide in an elderly population

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Health effects of acute exposure to air pollution. Part I: Healthy and asthmatic subjects exposed to diesel exhaust.

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Inflammation–coagulation network: are serine protease receptors the knot?

2000 • 103 citations

Modulation of airway sensitivity to inhaled irritants: role of inflammatory mediators.

2001 • 98 citations

Assessment of oxidant stress in allergic asthma by measurement of the major urinary metabolite of F₂‐isoprostane, 15‐F_2t‐IsoP (8‐iso‐PGF_2α)

2001 • 97 citations

Hourly elemental composition and sources identification of fine and coarse PM10 particulate matter in four Italian towns

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Diesel exhaust exposure enhances the expression of IL-13 in the bronchial epithelium of healthy subjects

2004 • 90 citations

Phagocytosis of particulate air pollutants by human alveolar macrophages stimulates the bone marrow

2000 • 89 citations

Short-Term Effects of Air Pollution on Heart Rate Variability in Senior Adults in Steubenville, Ohio

2006 • 88 citations

HFE Genotype, Particulate Air Pollution, and Heart Rate Variability

2006 • 88 citations

Characterization of chemical species in PM2.5 and PM10 aerosols in suburban and rural sites of central Taiwan

1999 • 88 citations

Air Pollution and Hospital Admissions for Diseases of the Circulatory System in Three U.S. Metropolitan Areas

2000 • 86 citations

Runs of Ventricular and Supraventricular Tachycardia Triggered by Air Pollution in Patients with Coronary Heart Disease

2006 • 86 citations

Relation Between Sources of Particulate Air Pollution and Biological Effect Parameters in Samples from Four European Cities: An Exploratory Study

2006 • 83 citations

Invited Commentary: Particulate Matter-Mortality Exposure-Response Relations and Threshold

2000 • 74 citations

The procoagulant potential of environmental particles (PM₁₀)

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When Nanoparticles Get in the Way: Impact of Projected Area on In Vivo and In Vitro Macrophage Function

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Short-Term Effects of Low-Level Air Pollution on Respiratory Health of Adults Suffering from Moderate to Severe Asthma

2002 • 66 citations

Activation of the EGF receptor signaling pathway in airway epithelial cells exposed to Utah Valley PM

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Silica Particles Enhance Peripheral Thrombosis

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Lung Rejection and Bronchial Hyperresponsiveness to Methacholine and Ultrasonically Nebulized Distilled Water in Heart-Lung Transplantation Patients

1989 • 63 citations

Microbial stimulation as an aetiologic factor in atopic disease

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Exposure to Wear Particles Generated from Studded Tires and Pavement Induces Inflammatory Cytokine Release from Human Macrophages

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Effects of Inhaled Capsaicin in Heart-Lung Transplant Patients and Asthmatic Subjects

1993 • 61 citations

Showdown Over Clean Air Science

1997 • 60 citations

Setting ambient air quality standards for particulate matter

2002 • 59 citations

Ultrafine particles in alveolar macrophages from normal children

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Interactions of exogenous or evoked agents and particles: the role of reactive oxygen species

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A comparison of urban and rural aerosol composition using dichotomous samplers

1984 • 49 citations

An analysis of winds affecting air pollution concentrations in Hong Kong

1998 • 48 citations

Health effects of acute exposure to air pollution. Part II: Healthy subjects exposed to concentrated ambient particles.

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Inhalation of PM2.5 does not modulate host defense or immune parameters in blood or lung of normal human subjects.

2001 • 44 citations

Air pollutants and cough

2006 • 42 citations

Sources, distribution and variability of airborne particles and hydrocarbons in La Plata area, Argentina

1999 • 36 citations

Acute Phase Reaction in Healthy Volunteers After Bronchoscopy With Lavage

2006 • 35 citations

Lack of spatial variation of endotoxin in ambient particulate matter across a German metropolitan area

2005 • 34 citations

CARDIORESPIRATORY EFFECTS OF CONCENTRATED AMBIENT PM2.5: A Pilot Study Using Controlled Human Exposures

2000 • 34 citations

What's Wrong with the National Ambient Air Quality Standard (NAAQS) for Fine Particulate Matter (PM2.5)?

2002 • 30 citations

The Biological Basis and Measurement of Thresholds

1986 • 30 citations

The Question of Nonlinearity in the Dose-Response Relation between Particulate Matter Air Pollution and Mortality: Can Akaike's Information Criterion be Trusted to Take the Right Turn?

2006 • 27 citations

The particulate air pollution controversy: a case study and lessons learned

2003 • 26 citations

Cardiovascular Toxicity of Inhaled Ambient Particulate Matter

2000 • 23 citations

Activation of the Autonomic Nervous System and Blood Coagulation in Association with an Air Pollution Episode

2000 • 23 citations

Conventional and toxicogenomic assessment of the acute pulmonary damage induced by the instillation of Cardiff PM10 into the rat lung

2006 • 19 citations

Multivariate data analysis of aerosols collected on the Gulf of Finland

1996 • 15 citations

CARDIORESPIRATORY EFFECTS OF CONCENTRATED AMBIENT PM2.5: A Pilot Study Using Controlled Human Exposures

2000 • 13 citations

The direct and indirect action of inhaled agents on the lung and its circulation: lessons for clinical science.

2001 • 12 citations

Multivariate analysis for investigating profile sources of atmospheric heavy metals emissions

2003 • 10 citations

Exploration of multivariate atmospheric particulate compositional data by projection pursuit

1994 • 9 citations

The Particulate Air Pollution Controversy: A Case Study and Lessons Learned

2003 • 8 citations

The politics of breathing

2006 • 6 citations

Disorders of rhythm

1973 • 1 citations

Deleted Work

1955 • 0 citations