Chronic Obstructive Pulmonary Disease

Randomised, double blind, placebo controlled study of fluticasone propionate in patients with moderate to severe chronic obstructive pulmonary disease: the ISOLDE trial

2000 • 1,684 citations

A Controlled Trial of Sustained-Release Bupropion, a Nicotine Patch, or Both for Smoking Cessation

1999 • 1,635 citations

The global burden of disease, 1990–2020

1998 • 1,601 citations

Effects of smoking intervention and the use of an inhaled anticholinergic bronchodilator on the rate of decline of FEV1. The Lung Health Study

1994 • 1,581 citations

Requirement for Macrophage Elastase for Cigarette Smoke-Induced Emphysema in Mice

1997 • 1,463 citations

Differences in interleukin-8 and tumor necrosis factor-alpha in induced sputum from patients with chronic obstructive pulmonary disease or asthma.

1996 • 1,370 citations

Weight Loss Is a Reversible Factor in the Prognosis of Chronic Obstructive Pulmonary Disease

1998 • 1,085 citations

Long-Term Treatment with Inhaled Budesonide in Persons with Mild Chronic Obstructive Pulmonary Disease Who Continue Smoking

1999 • 1,057 citations

A Comparison of Noninvasive Positive-Pressure Ventilation and Conventional Mechanical Ventilation in Patients with Acute Respiratory Failure

1998 • 1,003 citations

Results at 1 year of outpatient multidisciplinary pulmonary rehabilitation: a randomised controlled trial

2000 • 928 citations

Effect of Systemic Glucocorticoids on Exacerbations of Chronic Obstructive Pulmonary Disease

1999 • 864 citations

Oxidative Stress in Chronic Obstructive Pulmonary Disease

1997 • 851 citations

Meta-analysis of respiratory rehabilitation in chronic obstructive pulmonary disease

1996 • 836 citations

Long-term effect of inhaled budesonide in mild and moderate chronic obstructive pulmonary disease: a randomised controlled trial

1999 • 833 citations

CD8⁺ T-Lymphocytes in Peripheral Airways of Smokers with Chronic Obstructive Pulmonary Disease

1998 • 783 citations

Systemic oxidative stress in asthma, COPD, and smokers.

1996 • 781 citations

Peripheral Muscle Weakness in Patients with Chronic Obstructive Pulmonary Disease

1998 • 772 citations

Association of chronic mucus hypersecretion with FEV1 decline and chronic obstructive pulmonary disease morbidity. Copenhagen City Heart Study Group.

1996 • 730 citations

Relation of sputum inflammatory markers to symptoms and lung function changes in COPD exacerbations

2000 • 724 citations

Inflammation in bronchial biopsies of subjects with chronic bronchitis: inverse relationship of CD8+ T lymphocytes with FEV1.

1997 • 699 citations

Phosphodiesterase Isozymes

1998 • 655 citations

Opposing effects of glucocorticoids on the rate of apoptosis in neutrophilic and eosinophilic granulocytes.

1996 • 613 citations

Oral corticosteroids in patients admitted to hospital with exacerbations of chronic obstructive pulmonary disease: a prospective randomised controlled trial

1999 • 597 citations

Effects of inhaled and oral glucocorticoids on inflammatory indices in asthma and COPD.

1997 • 564 citations

Severity of Airflow Limitation Is Associated with Severity of Airway Inflammation in Smokers

1998 • 564 citations

Airway eosinophilia in chronic bronchitis during exacerbations.

1994 • 537 citations

Measurement of Symptoms, Lung Hyperinflation, and Endurance during Exercise in Chronic Obstructive Pulmonary Disease

1998 • 534 citations

Efficacy of Salmeterol Xinafoate in the Treatment of COPD

1999 • 532 citations

Evidence for a relation between metabolic derangements and increased levels of inflammatory mediators in a subgroup of patients with chronic obstructive pulmonary disease.

1996 • 526 citations

Results of 150 consecutive bilateral lung volume reduction procedures in patients with severe emphysema

1996 • 523 citations

Multicentre randomised placebo-controlled trial of inhaled fluticasone propionate in patients with chronic obstructive pulmonary disease

1998 • 517 citations

Increased exhalation of hydrogen peroxide in patients with stable and unstable chronic obstructive pulmonary disease.

1996 • 497 citations

Meta-analysis on efficacy of nicotine replacement therapies in smoking cessation

1994 • 489 citations

Antibiotics in chronic obstructive pulmonary disease exacerbations. A meta-analysis

1995 • 488 citations

Tumor necrosis factor-alpha levels and weight loss in chronic obstructive pulmonary disease.

1994 • 487 citations

Alveolar inflammation and its relation to emphysema in smokers.

1995 • 475 citations

Physiologic effects of nutritional support and anabolic steroids in patients with chronic obstructive pulmonary disease. A placebo-controlled randomized trial.

1995 • 467 citations

Nasal pressure support ventilation plus oxygen compared with oxygen therapy alone in hypercapnic COPD.

1995 • 463 citations

Matrix Metalloproteinase Expression and Production by Alveolar Macrophages in Emphysema

1997 • 444 citations

Association between polymorphism in gene for microsomal epoxide hydrolase and susceptibility to emphysema

1997 • 439 citations

Effect of High Dose Inhaled Steroid on Cells, Cytokines, and Proteases in Induced Sputum in Chronic Obstructive Pulmonary Disease

1999 • 419 citations

Identification of a Potent, Selective Non-peptide CXCR2 Antagonist That Inhibits Interleukin-8-induced Neutrophil Migration

1998 • 415 citations

Ongoing airway inflammation in patients with COPD who do not currently smoke

2000 • 393 citations

Genetic Epidemiology of Severe, Early-onset Chronic Obstructive Pulmonary Disease

1998 • 388 citations

Effect of Lung-Volume–Reduction Surgery in Patients with Severe Emphysema

2000 • 386 citations

Effect of long-term oxygen therapy on survival in patients with chronic obstructive pulmonary disease with moderate hypoxaemia

1997 • 366 citations

Elevated TNF-alpha production by peripheral blood monocytes of weight-losing COPD patients.

1996 • 342 citations

Structural and inflammatory changes in COPD: a comparison with asthma.

1998 • 332 citations

Neutrophil elastase and cathepsin G stimulate secretion from cultured bovine airway gland serous cells.

1990 • 325 citations

Exhaled Nitric Oxide in Chronic Obstructive Pulmonary Disease

1998 • 324 citations

Methacholine reactivity predicts changes in lung function over time in smokers with early chronic obstructive pulmonary disease. The Lung Health Study Research Group.

1996 • 322 citations

Inflammatory cells and mediators in bronchial lavage of patients with chronic obstructive pulmonary disease

1998 • 316 citations

Mechanisms in COPD

2000 • 308 citations

An evaluation of salmeterol in the treatment of chronic obstructive pulmonary disease (COPD)

1997 • 278 citations

Neutrophils and Protease/Antiprotease Imbalance

1999 • 275 citations

Tiotropium (SPIRIVA™): Mechanistical considerations and clinical profile in obstructive lung disease

1999 • 275 citations

Prospective Randomized Trial Comparing Bilateral Lung Volume Reduction Surgery to Pulmonary Rehabilitation in Severe Chronic Obstructive Pulmonary Disease

1999 • 274 citations

A randomized trial of nocturnal oxygen therapy in chronic obstructive pulmonary disease patients

1999 • 268 citations

Woodsmoke Exposure and Risk for Obstructive Airways Disease Among Women

1996 • 265 citations

Nocturnal Positive-Pressure Ventilation via Nasal Mask in Patients with Severe Chronic Obstructive Pulmonary Disease

1991 • 264 citations

Metalloproteinase inhibitors and the prevention of connective tissue breakdown

1996 • 260 citations

Chronic Obstructive Pulmonary Disease Is Associated with an Increase in Urinary Levels of Isoprostane F_{2 α}-III, an Index of Oxidant Stress

1998 • 260 citations

Noninvasive ventilatory support does not facilitate recovery from acute respiratory failure in chronic obstructive pulmonary disease

1996 • 258 citations

Latent Adenoviral Infection in the Pathogenesis of Chronic Airways Obstruction

1992 • 246 citations

Matrix Metalloproteinases

1999 • 245 citations

Tumor Necrosis Factor- α Gene Polymorphism in Chronic Bronchitis

1997 • 243 citations

Neutrophil Granule Proteins in Bronchoalveolar Lavage Fluid from Subjects with Subclinical Emphysema

1999 • 236 citations

The Interrelationship of Sputum Inflammatory Markers in Patients with Chronic Bronchitis

1999 • 233 citations

Genetic risk factors for chronic obstructive pulmonary disease

1997 • 230 citations

Effect of temperature on lung function and symptoms in chronic obstructive pulmonary disease

1999 • 229 citations

Long-Term Oxygen Therapy

1995 • 223 citations

Plasma Leptin Is Related to Proinflammatory Status and Dietary Intake in Patients with Chronic Obstructive Pulmonary Disease

1999 • 214 citations

Effect of smoking cessation on airway inflammation in chronic bronchitis.

1995 • 210 citations

Rationale and Design of the National Emphysema Treatment Trial

1999 • 201 citations

Expression of Adhesion Molecules and G Proteins in Circulating Neutrophils in Chronic Obstructive Pulmonary Disease

1998 • 161 citations

ArifloTM(SB 207499), a Second Generation Phosphodiesterase 4 Inhibitor for the Treatment of Asthma and COPD: from Concept to Clinic

1999 • 157 citations

Teaching medical students about tobacco

1999 • 149 citations

Genetics and pulmonary medicine bullet 9: Molecular genetics of chronic obstructive pulmonary disease

1999 • 139 citations

Proteinase 3, a Potent Secretagogue in Airways, Is Present in Cystic Fibrosis Sputum

1999 • 130 citations

Altered expression of myosin heavy chain in the vastus lateralis muscle in patients with COPD

1999 • 127 citations

Urinary desmosine excretion in smokers with and without rapid decline of lung function: the Normative Aging Study.

1996 • 126 citations

Extended Therapy With Ipratropium Is Associated With Improved Lung Function in Patients With COPD

1996 • 126 citations

Genetics and respiratory disease bullet 2: Alpha1-antitrypsin deficiency, cirrhosis and emphysema

1998 • 125 citations

Serial measurements of exhaled nitric oxide during exacerbations of chronic obstructive pulmonary disease

1999 • 122 citations

Relation between Preoperative Inspiratory Lung Resistance and the Outcome of Lung-Volume–Reduction Surgery for Emphysema

1998 • 118 citations

Anti-tnfα therapy is useful in rheumatoid arthritis and crohn’s disease: analysis of the mechanism of action predicts utility in other diseases

1998 • 116 citations

Domiciliary nocturnal intermittent positive pressure ventilation in patients with respiratory failure due to severe COPD: long term follow up and effect on survival

1998 • 116 citations

Perforin-Independent CD8⁺T-Cell–Mediated Cytotoxicity of Alveolar Epithelial Cells Is Preferentially Mediated by Tumor Necrosis Factor- α

1999 • 105 citations

Novel Approaches and Targets for Treatment of Chronic Obstructive Pulmonary Disease

1999 • 98 citations

Tumour necrosis factor-α gene promoter polymorphism in chronic obstructive pulmonary disease

2000 • 94 citations

MR889, a neutrophil elastase inhibitor, in patients with chronic obstructive pulmonary disease: a double-blind, randomized, placebo-controlled clinical trial

1996 • 94 citations

Asthma Attacks with Eosinophilia Predict Mortality from Chronic Obstructive Pulmonary Disease in a General Population Sample

1999 • 89 citations

New therapies for chronic obstructive pulmonary disease.

1998 • 77 citations

Effect of salmeterol on Haemophilus influenzae infection of respiratory mucosa in vitro

1998 • 76 citations

No Effect of Inhaled Budesonide on the Response to Inhaled Ozone in Normal Subjects

2000 • 76 citations

Excessive neutrophil elastase in bronchoalveolar lavage fluid in subclinical emphysema.

1995 • 68 citations

Effects of formoterol in apparently poorly reversible chronic obstructive pulmonary disease

1999 • 64 citations

Endotoxin-mediated nitric oxide synthesis inhibits IL-1β gene transcription in ANA-1 murine macrophages

1999 • 48 citations

Chest Illness in Infancy and Chronic Respiratory Disease in Later Life: An Analysis by Month of Birth

1994 • 26 citations

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