Effects of Calorie Restriction on Polymicrobial Peritonitis Induced by Cecum Ligation and Puncture in Young C57BL/6 Mice

Definitions for Sepsis and Organ Failure and Guidelines for the Use of Innovative Therapies in Sepsis

1992 • 12,726 citations

CD14, a Receptor for Complexes of Lipopolysaccharide (LPS) and LPS Binding Protein

1990 • 4,041 citations

Development of T _H 1 CD4 ⁺ T Cells Through IL-12 Produced by Listeria -Induced Macrophages

1993 • 3,140 citations

Oxidative Stress, Caloric Restriction, and Aging

1996 • 3,136 citations

The p66shc adaptor protein controls oxidative stress response and life span in mammals

1999 • 1,688 citations

The retardation of aging and disease by dietary restriction

1989 • 1,494 citations

Toll-like receptor-2 mediates lipopolysaccharide-induced cellular signalling

1998 • 1,218 citations

The Retardation of Aging in Mice by Dietary Restriction: Longevity, Cancer, Immunity and Lifetime Energy Intake

1986 • 968 citations

A CONSERVED SIGNALING PATHWAY: The Drosophila Toll-Dorsal Pathway

1996 • 822 citations

Human Toll-like Receptor 2 Confers Responsiveness to Bacterial Lipopolysaccharide

1998 • 778 citations

Dietary Restriction in Mice Beginning at 1 Year of Age: Effect on Life-Span and Spontaneous Cancer Incidence

1982 • 757 citations

Caloric restriction and aging: an update

2000 • 616 citations

Evaluation of factors affecting mortality rate after sepsis in a murine cecal ligation and puncture model.

1983 • 507 citations

Cloning and expression of murine IL-12.

1992 • 474 citations

Regulation of human lymphocyte proliferation by a heterodimeric cytokine, IL-12 (cytotoxic lymphocyte maturation factor).

1991 • 471 citations

The systemic inflammatory response syndrome

2001 • 416 citations

Expression of Heat Shock Protein 70 is Altered by Age and Diet at the Level of Transcription

1993 • 284 citations

Influence of diet on survival of mice.

1976 • 261 citations

An overview of mortality risk prediction in sepsis

1995 • 251 citations

Assessment of the Role of the Glucocorticoid System in Aging Processes and in the Action of Food Restriction

1991 • 245 citations

The C/EBP Family of Transcription Factors

1995 • 236 citations

Calorie restriction inhibits the age-related dysregulation of the cytokines TNF-α and IL-6 in C3B10RF1 mice

1997 • 221 citations

Dietary Restriction and Aging: The Initiation of a Primate Study

1990 • 220 citations

Controlling caloric consumption: protocols for rodents and rhesus monkeys☆

1999 • 177 citations

Activities of antioxidant enzymes in various tissues of male Fischer 344 rats are altered by food restriction.

1995 • 170 citations

Influence of dietary restriction on immunologic function and renal disease in (NZB × NZW) F ₁ mice

1978 • 167 citations

Gene expressions of lipopolysaccharide receptors, toll-like receptors 2 and 4, are differently regulated in mouse T lymphocytes

2000 • 153 citations

Methods in Aging Research

1998 • 149 citations

Dietary restriction : implications for the design and interpretation of toxicity and carcinogenicity studies

1995 • 148 citations

Caloric Restriction Mimetics: Metabolic Interventions

2001 • 147 citations

Biological Effects of Dietary Restriction

1991 • 144 citations

Pulmonary and Hepatic Gene Expression following Cecal Ligation and Puncture: Monophosphoryl Lipid A Prophylaxis Attenuates Sepsis-Induced Cytokine and Chemokine Expression and Neutrophil Infiltration

1998 • 142 citations

Oxidative injury and survival during endotoxemia

1998 • 118 citations

Longterm dietary restriction and immune function in mice: Response to sheep red blood cells and to mitogenic agents

1973 • 117 citations

Tumor Necrosis Factor Alpha Gene Regulation: Enhancement of C/EBPβ-Induced Activation by c-Jun

1998 • 117 citations

Increased Susceptibility to Postoperative Sepsis in Patients with Impaired Monocyte IL-12 Production

1998 • 116 citations

Oxygen free radicals in ARDS, septic shock and organ dysfunction

2000 • 113 citations

Suppression of adenocarcinoma by the immunological consequences of calorie restriction

1976 • 110 citations

Caloric intake and aging: mechanisms in rodents and a study in nonhuman primates

1999 • 98 citations

Cross-talk between transcription factors NF-κB and C/EBP in the transcriptional regulation of genes

1997 • 93 citations

Effect of food restriction on life span and immune functions in long-lived Fischer-344 x Brown Norway F1 rats.

1997 • 88 citations

Polymicrobial sepsis selectively activates peritoneal but not alveolar macrophages to release inflammatory mediators (interleukins-1 and -6 and tumor necrosis factor).

1992 • 88 citations

A Study of Caloric Restriction and Cardiovascular Aging in Cynomolgus Monkeys (Macacafascicularis): A Potential Model for Aging Research

1997 • 83 citations

Hemorrhage induces enhanced Kupffer cell cytotoxicity while decreasing peritoneal or splenic macrophage capacity. Involvement of cell-associated tumor necrosis factor and reactive nitrogen.

1991 • 77 citations

Energy Restriction and Zinc Deficiency Impair the Functions of Murine T Cells and Antigen-Presenting Cells during Gastrointestinal Nematode Infection ,

1998 • 77 citations

The Role of Protein and Calorie Restriction in Outcome From Salmonella Infection in Mice

1992 • 67 citations

Expression of MHC class II molecules contributes to lipopolysaccharide responsiveness

2000 • 63 citations

Influence of caloric intake on aging and on the response to stressors

1998 • 63 citations

Is Sepsis-Induced Apoptosis Associated with Macrophage Dysfunction?

1996 • 62 citations

Caloric intake and aging: mechanisms in rodents and a study in nonhuman primates

1999 • 61 citations

Early Activation of Hepatic NFκB and NF-IL6 in Polymicrobial Sepsis Correlates With Bacteremia, Cytokine Expression, and Mortality

1999 • 60 citations

Calorie restriction decreases proinflammatory cytokines and polymeric Ig receptor expression in the submandibular glands of autoimmune prone (NZB x NZW)F1 mice.

2000 • 60 citations

Altered Alveolar Macrophage Function in Calorie-restricted Rats

1998 • 57 citations

Molecular biology of septic shock.

1998 • 54 citations

Delayed Immune Aging in Diet-Restricted B6CBAT6 Fl Mice Is Associated With Preservation of Naive T Cells

1998 • 53 citations

Mechanism of Splenic Immunosuppression During Sepsis

1997 • 53 citations

Prevention of Obesity in Middle‐Aged Monkeys: Food Intake During Body Weight Clamp

1995 • 52 citations

Suppression of cellular and humoral immunity to T-dependent antigens by calorie restriction

1984 • 52 citations

Modulation of antioxidant enzymes and apoptosis in mice by dietary lipids and treadmill exercise.

1999 • 52 citations

Physiologic Effects of Lowering Caloric Intake in Nonhuman Primates and Nonobese Humans

2001 • 51 citations

Nutritional factors: modulating effects on immune function and aging.

1984 • 46 citations

Gene expression of hematoregulatory cytokines is elevated endogenously after sublethal gamma irradiation and is differentially enhanced by therapeutic administration of biologic response modifiers.

1994 • 45 citations

Sepsis

1999 • 45 citations

Early Activation of Pulmonary Nuclear Factor kappa B and Nuclear Factor Interleukin-6 in Polymicrobial Sepsis

1999 • 42 citations

Calorie Restriction Reduces Ulcerative Dermatitis and Infection-Related Mortality in p53-Deficient and Wild-Type Mice

1998 • 31 citations

Modulation of antioxidant activities and immune response by food restriction in aging Fischer-344 rats

1995 • 30 citations

The Increase in the Induction of IL-2 Expression with Caloric Restriction Is Correlated to Changes in the Transcription Factor NFAT

1997 • 28 citations

Potential of Diet Therapy on Murine AIDS ,

1992 • 28 citations

Calorie restriction, stress and the ubiquitin-dependent pathway in mouse livers

1998 • 26 citations

Does Endotoxin Play a Major Role in Inducing the Depression of Macrophage Function During Polymicrobial Sepsis?

1995 • 25 citations

Effects of energy intake on type 1 plasminogen activator inhibitor levels in glomeruli of lupus-prone B/W mice.

1995 • 24 citations

Calorie restriction modulates Th-1 and Th-2 cytokine-induced immunoglobulin secretion in young and old C57BL/6 cultured submandibular glands

1999 • 17 citations

Prevention of Free Radical Damage by Food Restriction

1991 • 17 citations

Methods for the Study of Immune Cells in Aging

1998 • 8 citations

Deleted Work

1955 • 0 citations