An inducible enhancer controls the expression of the human interleukin 1 beta gene.

Molecular Cloning: A Laboratory Manual

2001 • 133,517 citations

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Improved M13 phage cloning vectors and host strains: nucleotide sequences of the M13mpl8 and pUC19 vectors

1985 • 15,222 citations

A comprehensive set of sequence analysis programs for the VAX

1984 • 14,824 citations

Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells.

1982 • 8,069 citations

[2] New M13 vectors for cloning

1983 • 5,402 citations

CpG-rich islands and the function of DNA methylation

1986 • 3,760 citations

Firefly luciferase gene: structure and expression in mammalian cells.

1987 • 3,088 citations

Phorbol ester-inducible genes contain a common cis element recognized by a TPA-modulated trans-acting factor

1987 • 3,057 citations

Cloning, sequence and expression of two distinct human interleukin-1 complementary DNAs

1985 • 1,594 citations

Transformation of mammalian cells with genes from procaryotes and eucaryotes

1979 • 1,474 citations

A lymphocyte-specific cellular enhancer is located downstream of the joining region in immunoglobulin heavy chain genes

1983 • 1,449 citations

A tissue-specific transcription enhancer element is located in the major intron of a rearranged immunoglobulin heavy chain gene

1983 • 1,418 citations

There is more than one interleukin 1

1986 • 1,226 citations

Nucleotide sequence of human monocyte interleukin 1 precursor cDNA.

1984 • 1,042 citations

Induction of maturation in cultured human monocytic leukemia cells by a phorbol diester.

1982 • 797 citations

CpG methylation of the cAMP-responsive enhancer/promoter sequence TGACGTCA abolishes specific factor binding as well as transcriptional activation.

1989 • 554 citations

α-Interferon-induced transcription of HLA and metallothionein genes containing homologous upstream sequences

1985 • 498 citations

Expression and regulation of Escherichia coli lacZ gene fusions in mammalian cells.

1983 • 471 citations

DNA methylation and the regulation of globin gene expression

1983 • 451 citations

Interferons and other regulatory cytokines

1988 • 429 citations

The human β-interferon gene enhancer is under negative control

1986 • 395 citations

Double-stranded RNA activates binding of NF-kappa B to an inducible element in the human beta-interferon promoter.

1989 • 317 citations

Overlapping positive and negative regulatory domains of the human beta-interferon gene.

1988 • 237 citations

Regulation of Cytokine Gene Expression

1988 • 234 citations

Activity of two different silencer elements of the chicken lysozyme gene can be compensated by enhancer elements.

1987 • 226 citations

Interferons as macrophage-activating factors. III. Preferential effects of interferon-gamma on the interleukin 1 secretory potential of fresh or aged human monocytes.

1985 • 217 citations

Human pro-IL-1 beta gene expression in monocytic cells is regulated by two distinct pathways.

1988 • 206 citations

BK Viral Enhancer Element and a Human Cellular Homolog

1983 • 175 citations

Identification of a cell-specific transcriptional enhancer in the first intron of the mouse alpha 2 (type I) collagen gene.

1987 • 169 citations

Two different virus-inducible elements are required for human beta-interferon gene regulation.

1989 • 168 citations

Determinants of Rat Albumin Promoter Tissue Specificity Analyzed by an Improved Transient Expression System

1987 • 166 citations

Interleukin 1: more than a mediator between leukocytes

1988 • 120 citations

Detection of IL-1 alpha and IL-1 beta gene expression by in situ hybridization. Tissue localization of IL-1 mRNA in the normal C57BL/6 mouse.

1988 • 120 citations

The lysozyme enhancer: cell-specific activation of the chicken lysozyme gene by a far-upstream DNA element.

1986 • 118 citations

Interactions between the Promoter and First Intron Are Involved in Transcriptional Control of α1(I) Collagen Gene Expression

1988 • 105 citations

Lysozyme gene activity in chicken macrophages is controlled by positive and negative regulatory elements

1987 • 92 citations

Identification of the human beta-actin enhancer and its binding factor.

1988 • 67 citations

Identification of negative and positive regulatory elements associated with a class I major histocompatibility complex gene.

1988 • 65 citations

Localization of a repressive sequence contributing to B-cell specificity in the immunoglobulin heavy-chain enhancer.

1988 • 53 citations

Interleukin 1 production by a human acute monocytic leukemia cell line

1983 • 45 citations

Interleukin 1 production by the human monocyte cell line U937 requires a lymphokine induction signal distinct from interleukin 2 or interferons.

1985 • 44 citations

Isolation and Initial Characterization of Tumoricidal Monokine(s) From the Human Monocytic Leukemia Cell Line THP-1<xref ref-type="fn" rid="FN2">2</xref>

1985 • 18 citations

Secretion of interleukin-1 beta by a leukemia cell line in response to lipopolysaccharide and mezerein.

1990 • 3 citations