Hyperglycemia Alters Tumor Necrosis Factor-α Release from Mononuclear Cells in Women with Polycystic Ovary Syndrome

Isolation of mononuclear cells and granulocytes from human blood.

1968 • 9,672 citations

Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome

2004 • 8,489 citations

Obesity is associated with macrophage accumulation in adipose tissue

2003 • 8,349 citations

Obesity is associated with macrophage accumulation in adipose tissue

2003 • 7,795 citations

Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance

1993 • 7,219 citations

Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance

2003 • 5,744 citations

Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance

2003 • 5,391 citations

Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp.

1999 • 5,310 citations

Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS)

2003 • 5,246 citations

Nuclear Factor-κB — A Pivotal Transcription Factor in Chronic Inflammatory Diseases

1997 • 4,661 citations

Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance.

1995 • 3,454 citations

C-Reactive Protein in Healthy Subjects: Associations With Obesity, Insulin Resistance, and Endothelial Dysfunction

1999 • 2,478 citations

Insulin Resistance and the Polycystic Ovary Syndrome: Mechanism and Implications for Pathogenesis*

1997 • 2,442 citations

Men at risk: occupation and male infertility

2004 • 2,392 citations

Oxidative Stress and Stress-Activated Signaling Pathways: A Unifying Hypothesis of Type 2 Diabetes

2002 • 2,164 citations

Prevalence of the Polycystic Ovary Syndrome in Unselected Black and White Women of the Southeastern United States: A Prospective Study¹

1998 • 1,550 citations

Comparison of the Release of Adipokines by Adipose Tissue, Adipose Tissue Matrix, and Adipocytes from Visceral and Subcutaneous Abdominal Adipose Tissues of Obese Humans

2004 • 1,518 citations

Tumor necrosis factor alpha inhibits signaling from the insulin receptor.

1994 • 1,173 citations

Insulin Resistance and the Polycystic Ovary Syndrome: Mechanism and Implications for Pathogenesis

1997 • 1,134 citations

Correlation of Hyperandrogenism with Hyperinsulinism in Polycystic Ovarian Disease*

1980 • 910 citations

Mechanisms of insulin resistance in human obesity: evidence for receptor and postreceptor defects.

1980 • 665 citations

Glucose Challenge Stimulates Reactive Oxygen Species (ROS) Generation by Leucocytes

2000 • 598 citations

Low Grade Chronic Inflammation in Women with Polycystic Ovarian Syndrome

2001 • 589 citations

Insulin Stimulates Testosterone Biosynthesis by Human Thecal Cells from Women with Polycystic Ovary Syndrome by Activating Its Own Receptor and Using Inositolglycan Mediators as the Signal Transduction System¹

1998 • 571 citations

Tumor necrosis factor-alpha suppresses insulin-induced tyrosine phosphorylation of insulin receptor and its substrates.

1993 • 543 citations

Tumor Necrosis Factor-α in Sera of Obese Patients: Fall with Weight Loss

1998 • 543 citations

Endotoxin tolerance: A review

2002 • 518 citations

Downregulation of proinflammatory cytokine release in whole blood from septic patients

1995 • 451 citations

Transcriptional repression of the GLUT4 and C/EBP genes in 3T3-L1 adipocytes by tumor necrosis factor-alpha.

1991 • 369 citations

Increased C-Reactive Protein Levels in the Polycystic Ovary Syndrome: A Marker of Cardiovascular Disease

2004 • 330 citations

Effects of obesity on women's reproduction and complications during pregnancy

2004 • 293 citations

Body mass index, waist girth, and waist-to-hip ratio as indexes of total and regional adiposity in women: evaluation using receiver operating characteristic curves

1998 • 287 citations

Insulin Resistance in Aging Is Related to Abdominal Obesity

1993 • 285 citations

Body composition characteristics and body fat distribution in lean women with polycystic ovary syndrome

2001 • 281 citations

Dysregulation of LPS-Induced Toll-Like Receptor 4-MyD88 Complex Formation and IL-1 Receptor-Associated Kinase 1 Activation in Endotoxin-Tolerant Cells

2002 • 274 citations

Metformin Reduces Serum C-Reactive Protein Levels in Women with Polycystic Ovary Syndrome

2003 • 249 citations

TNF-α impairs insulin signaling and insulin stimulation of glucose uptake in C₂C₁₂muscle cells

1999 • 237 citations

Insulin resistance in polycystic ovary syndrome: decreased expression of GLUT-4 glucose transporters in adipocytes

1993 • 216 citations

TNFα release by the nonfat cells of human adipose tissue

2004 • 203 citations

Insulin resistance in polycystic ovary syndrome

1983 • 194 citations

Elevated serum levels of tumor necrosis factor alpha in normal-weight women with polycystic ovary syndrome

1999 • 192 citations

Relation of intra-abdominal fat distribution to metabolic disorders in nonobese patients with polycystic ovary syndrome

2003 • 190 citations

Ethinylestradiol-Drospirenone, Flutamide-Metformin, or Both for Adolescents and Women with Hyperinsulinemic Hyperandrogenism: Opposite Effects on Adipocytokines and Body Adiposity

2004 • 173 citations

Serum and follicular fluid cytokines in polycystic ovary syndrome during stimulated cycles

2003 • 168 citations

Free Fatty Acids—The Link Between Obesity and Insulin Resistance

2001 • 136 citations

Inflammation, Insulin Resistance, and Adiposity

2004 • 130 citations

The importance of insulin resistance in polycystic ovary syndrome

2003 • 112 citations

Bone mineral density and body composition in lean women with polycystic ovary syndrome

1999 • 102 citations

Mechanism of the postreceptor defect in insulin action in human obesity. Decrease in glucose transport system activity.

1981 • 94 citations

Human aging is associated with altered TNF-α production during hyperglycemia and hyperinsulinemia

2001 • 87 citations

The p50-homodimer mechanism in tolerance to LPS

2001 • 84 citations

Evaluation of WHO and NDDG Criteria for Impaired Glucose Tolerance: Results From Two National Samples

1989 • 81 citations

Insulin Resistance in Polycystic Ovarian Syndromea

1993 • 59 citations

Serum and Follicular Fluid Cytokines in Polycystic Ovary Syndrome During Stimulated Cycles

2003 • 52 citations

Elevated serum TNF-alpha levels in normal-weight women with polycystic ovaries or the polycystic ovary syndrome.

2003 • 49 citations

Endotoxin-induced cytokine production of monocytes of third-trimester pregnant women compared with women in the follicular phase of the menstrual cycle

2003 • 49 citations

Flutamide-metformin plus an oral contraceptive (OC) for young women with polycystic ovary syndrome: switch from third- to fourth-generation OC reduces body adiposity

2004 • 44 citations

Minimally invasive surgery induces endotoxin-tolerance in the absence of detectable endotoxemia.

1998 • 33 citations

SERUM C-REACTIVE PROTEIN (CRP) IS RELATED TO AGE AND BODY MASS INDEX (BMI) IN PATIENTS WITH POLYCYSTIC OVARY SYNDROME (PCOS) BUT NOT TO INSULIN SENSITIVITY

2003 • 4 citations