Downregulation of proinflammatory cytokine release in whole blood from septic patients

Molecular cloning: A laboratory manual

1990 • 85,659 citations

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

CD14, a Receptor for Complexes of Lipopolysaccharide (LPS) and LPS Binding Protein

1990 • 4,041 citations

Shock and Tissue Injury Induced by Recombinant Human Cachectin

1986 • 2,587 citations

Anti-cachectin/TNF monoclonal antibodies prevent septic shock during lethal bacteraemia

1987 • 2,492 citations

Detection of Circulating Tumor Necrosis Factor after Endotoxin Administration

1988 • 1,711 citations

A highly sensitive cell line, WEHI 164 clone 13, for measuring cytotoxic factor/tumor necrosis factor from human monocytes

1986 • 1,282 citations

Interleukin 1 induces a shock-like state in rabbits. Synergism with tumor necrosis factor and the effect of cyclooxygenase inhibition.

1988 • 990 citations

lnterleukin-13 is a new human lymphokine regulating inflammatory and immune responses

1993 • 877 citations

Cachectin/tumor necrosis factor: production, distribution, and metabolic fate in vivo.

1985 • 788 citations

Tumor Necrosis Factor and Interleuktn-1 in the Serum of Children with Severe Infectious Purpura

1988 • 735 citations

Purification and NH2-terminal amino acid sequence of a T-cell-derived lymphokine with growth factor activity for B-cell hybridomas.

1986 • 701 citations

Prostaglandin E2 regulates macrophage-derived tumor necrosis factor gene expression.

1988 • 670 citations

Prognostic Values of Tumor Necrosis Factor/Cachectin, Interleukin-l, Interferon- , and Interferon- in the Serum of Patients with Septic Shock

1990 • 555 citations

Contrasting mechanisms for suppression of macrophage cytokine release by transforming growth factor-beta and interleukin-10

1992 • 516 citations

Tumor necrosis factor and interleukin-1 serum levels during severe sepsis in humans

1989 • 485 citations

RAISED SERUM LEVELS OF TUMOUR NECROSIS FACTOR IN PARASITIC INFECTIONS

1986 • 469 citations

Prostaglandins posttranscriptionally inhibit monocyte expression of interleukin 1 activity by increasing intracellular cyclic adenosine monophosphate.

1986 • 462 citations

Detection of interleukin 8 and tumor necrosis factor in normal humans after intravenous endotoxin: the effect of antiinflammatory agents.

1991 • 452 citations

Adherence induces selective mRNA expression of monocyte mediators and proto-oncogenes.

1988 • 411 citations

The Proinflammatory Cytokines Interleukin-l and Tumor Necrosis Factor and Treatment of the Septic Shock Syndrome

1991 • 409 citations

Glucocorticoids inhibit transcriptional and post-transcriptional expression of interleukin 1 in U937 cells.

1987 • 376 citations

Plasma Tumor Necrosis Factor in Patients with Septic Shock: Mortality Rate, Incidence of Adult Respiratory Distress Syndrome, and Effects of Methylprednisolone Administration

1990 • 335 citations

Plasma tumor necrosis factor and mortality in critically ill septic patients

1989 • 324 citations

IL-8 in septic shock, endotoxemia, and after IL-1 administration.

1991 • 313 citations

Plasma clearance, organ distribution and target cells of interleukin‐6/hepatocyte‐stimulating factor in the rat

1988 • 298 citations

Dissociation between interleukin-1 beta mRNA and protein synthesis in human peripheral blood mononuclear cells.

1990 • 225 citations

Enhancement of human B cell proliferation and differentiation by tumor necrosis factor-alpha and interleukin 1.

1987 • 214 citations

Prophylactic and Therapeutic Effects of a Monoclonal Antibody to Tumor Necrosis Factor- in Experimental Gram-Negative Shock

1990 • 200 citations

Effects of interferon-gamma and tumor necrosis factor-alpha on the expression of an Ia antigen on a murine macrophage cell line.

1986 • 199 citations

Pretreatment with recombinant murine tumor necrosis factor alpha/cachectin and murine interleukin 1 alpha protects mice from lethal bacterial infection.

1989 • 196 citations

Intravenous endotoxin suppresses the cytokine response of peripheral blood mononuclear cells of healthy humans.

1993 • 195 citations

Serial Quantitation of Endotoxemia and Bacteremia During Therapy for Gram-Negative Bacterial Sepsis

1988 • 178 citations

Interferon γ and lymphotoxin or tumor necrosis factor act synergistically to induce macrophage killing of tumor cells and schistosomula of schistosoma mansoni

1987 • 132 citations

Recombinant murine interleukin-1 alpha enhancement of nonspecific antibacterial resistance

1987 • 118 citations

In vivo dynamics of murine tumor necrosis factor-alpha gene expression. Kinetics of dexamethasone-induced suppression.

1989 • 115 citations

The Role of Prostaglandin E2 in Immune Suppression Following Injury

1991 • 110 citations

Chloroquine attenuates hemorrhagic shock-induced suppression of Kupffer cell antigen presentation and major histocompatibility complex class II antigen expression through blockade of tumor necrosis factor and prostaglandin release

1991 • 96 citations

Prevention and treatment of endotoxin and sepsis lethality with recombinant human tumor necrosis factor.

1989 • 85 citations

Fate and biological action of human recombinant interleukin 1β in the rat in vivo

1989 • 64 citations

Blockade of Prostaglandin Production Increases Cachectin Synthesis and Prevents Depression of Macrophage Functions After Hemorrhagic Shock

1991 • 62 citations

Regulation of the pathophysiology of tumor necrosis factor.

1990 • 62 citations

Desensitization of Macrophages to Endotoxin Effects Is Not Correlated with a Down-Regulation of Lipopolysaccharide-Binding Sites

1993 • 58 citations

Effects of human interleukin 1 and human tumor necrosis factor on human T lymphocyte colony formation.

1987 • 49 citations

B‐cell chronic lymphocytic leukaemia cells express and release transforming growth factor‐β

1992 • 49 citations

Increased Release of Soluble Tumor Necrosis Factor Receptors Into Blood During Clinical Sepsis

1994 • 46 citations

Single-dose tumor necrosis factor protection against endotoxin-induced shock and tissue injury in rats

1991 • 39 citations

Eicosanoids Regulate Tumor Necrosis Factor Synthesis After Hemorrhage In Vitro and In Vivo

1991 • 20 citations