Apolipoprotein E facilitates neuritic and cerebrovascular plaque formation in an Alzheimer's disease model

Gene Dose of Apolipoprotein E Type 4 Allele and the Risk of Alzheimer's Disease in Late Onset Families

1993 • 8,888 citations

Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease.

1993 • 4,145 citations

Correlative Memory Deficits, Aβ Elevation, and Amyloid Plaques in Transgenic Mice

1996 • 4,118 citations

Apolipoprotein E: Cholesterol Transport Protein with Expanding Role in Cell Biology

1988 • 3,984 citations

Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein

1995 • 2,456 citations

Protective effect of apolipoprotein E type 2 allele for late onset Alzheimer disease

1994 • 1,813 citations

Increased amyloid beta-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease.

1993 • 1,480 citations

Apolipoprotein E immunoreactivity in cerebral amyloid deposits and neurofibrillary tangles in Alzheimer's disease and kuru plaque amyloid in Creutzfeldt-Jakob disease

1991 • 1,133 citations

A mutation in the Amyloid Precursor Protein Associated with Hereditary Alzheimer's Disease

1991 • 1,121 citations

Cerebral amyloid angiopathy. A critical review.

1987 • 1,013 citations

New stereological methods for counting neurons

1993 • 951 citations

Apolipoprotein E isoform-dependent amyloid deposition and neuritic degeneration in a mouse model of Alzheimer's disease

2000 • 896 citations

Amyloid-associated proteins α1-antichymotrypsin and apolipoprotein E promote assembly of Alzheimer β-protein into filaments

1994 • 866 citations

Apolipoprotein E: A pathological chaperone protein in patients with cerebral and systemic amyloid

1992 • 802 citations

beta-Amyloid-(1-42) is a major component of cerebrovascular amyloid deposits: implications for the pathology of Alzheimer disease.

1993 • 713 citations

Lipoproteins and their receptors in the central nervous system. Characterization of the lipoproteins in cerebrospinal fluid and identification of apolipoprotein B,E(LDL) receptors in the brain.

1987 • 696 citations

APPSW Transgenic Mice Develop Age-related Aβ Deposits and Neuropil Abnormalities, but no Neuronal Loss in CA1

1997 • 640 citations

Amyloid precursor protein processing and Aβ ₄₂ deposition in a transgenic mouse model of Alzheimer disease

1997 • 624 citations

Microglial response to amyloid plaques in APPsw transgenic mice.

1998 • 580 citations

Isoform-specific binding of apolipoprotein E to beta-amyloid.

1994 • 529 citations

Apolipoprotein E ϵ4 and cerebral hemorrhage associated with amyloid angiopathy

1995 • 525 citations

Age-related CNS disorder and early death in transgenic FVB/N mice overexpressing Alzheimer amyloid precursor proteins

1995 • 521 citations

Aβ Deposition Is Associated with Neuropil Changes, but not with Overt Neuronal Loss in the Human Amyloid Precursor Protein V717F (PDAPP) Transgenic Mouse

1997 • 502 citations

Peptide Compositions of the Cerebrovascular and Senile Plaque Core Amyloid Deposits of Alzheimer′s Disease

1993 • 489 citations

Apolipoprotein E is essential for amyloid deposition in the APP ^V717F transgenic mouse model of Alzheimer's disease

1999 • 467 citations

Apolipoprotein E associates with beta amyloid peptide of Alzheimer's disease to form novel monofibrils. Isoform apoE4 associates more efficiently than apoE3.

1994 • 407 citations

The apolipoprotein ε4 allele in patients with Alzheimer's disease

1993 • 401 citations

Neuronal overexpression of mutant amyloid precursor protein results in prominent deposition of cerebrovascular amyloid

1999 • 392 citations

Differences Between Vascular and Plaque Core Amyloid in Alzheimer's Disease

1988 • 348 citations

Expression of human apolipoprotein E reduces amyloid-β deposition in a mouse model of Alzheimer's disease

1999 • 342 citations

Apolipoprotein E-epsilon4 alleles in cerebral amyloid angiopathy and cerebrovascular pathology associated with Alzheimer's disease.

1996 • 340 citations

Apolipoprotein E is a kinetic but not a thermodynamic inhibitor of amyloid formation: implications for the pathogenesis and treatment of Alzheimer disease.

1995 • 332 citations

Nascent Astrocyte Particles Differ from Lipoproteins in CSF

1998 • 281 citations

High frequency of apolipoprotein E ϵ2 Allele in hemorrhage due to cerebral amyloid angiopathy

1997 • 272 citations

Fibrillogenesis in Alzheimer's disease of amyloid β peptides and apolipoprotein E

1995 • 255 citations

Association of apolipoprotein E ϵ2 and vasculopathy in cerebral amyloid angiopathy

1998 • 247 citations

Apolipoprotein E ε4 Is Associated With the Presence and Earlier Onset of Hemorrhage in Cerebral Amyloid Angiopathy

1996 • 246 citations

Plaque-induced neurite abnormalities: Implications for disruption of neural networks in Alzheimer’s disease

1999 • 228 citations

Glial Fibrillary Acidic Protein–Apolipoprotein E (apoE) Transgenic Mice: Astrocyte-Specific Expression and Differing Biological Effects of Astrocyte-Secreted apoE3 and apoE4 Lipoproteins

1998 • 213 citations

The apolipoprotein E epsilon 4 allele is associated with increased neuritic plaques and cerebral amyloid angiopathy in Alzheimer's disease and Lewy body variant

1996 • 206 citations

β-Amyloid and the Pathogenesis of Alzheimer's Disease

1991 • 201 citations

Characterization of stable complexes involving apolipoprotein E and the amyloid β peptide in Alzheimer's disease brain

1995 • 190 citations

Protein chemical and immunocytochemical studies of meningovascular β-amyloid protein in Alzheimer's disease and normal aging

1988 • 173 citations

Is Alzheimer's disease an apolipoprotein E amyloidosis?

1995 • 156 citations

Genetic Modification of the Phenotypes Produced by Amyloid Precursor Protein Overexpression in Transgenic Mice

1997 • 151 citations

Apolipoprotein E and the Apolipoprotein E-Deficient Mouse

1995 • 142 citations

Cerebrovascular amyloidosis with cerebral hemorrhage

1977 • 133 citations

Seeding of Aβ Fibril Formation Is Inhibited by All Three Isotypes of Apolipoprotein E

1996 • 112 citations

Apolipoprotein E promotes the binding and uptake of β-amyloid into Chinese hamster ovary cells in an isoform-specific manner

1999 • 111 citations

Geometria degli indivisibili

1966 • 104 citations

Opposite roles of apolipoprotein E in normal brains and in Alzheimer’s disease

1998 • 90 citations

MK-801 neurotoxicity in male mice: histologic effects and chronic impairment in spatial learning

1996 • 87 citations

Apolipoprotein E isoform-specific reduction of extracellular amyloid in neuronal cultures

1999 • 77 citations

Structure and Functions of Human Cerebrospinal Fluid Lipoproteins from Individuals of Different APOE Genotypes

1998 • 64 citations

Detection of Apolipoprotein E/Dimeric Soluble Amyloid β Complexes in Alzheimer's Disease Brain Supernatants

1997 • 59 citations

Combined Amyloid Vascular Changes and Argyrophilic Plaques in the Central Nervous System

1960 • 58 citations

A modified cupric-silver technique for the impregnation of degenrating neurons and their processes

1981 • 55 citations