Toll‐Like Receptor 2–Deficient Mice Are Highly Susceptible toStreptococcus pneumoniaeMeningitis because of Reduced Bacterial Clearing and Enhanced Inflammation

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2001 • 4,673 citations

The Dorsoventral Regulatory Gene Cassette spätzle/Toll/cactus Controls the Potent Antifungal Response in Drosophila Adults

1996 • 3,854 citations

Differential Roles of TLR2 and TLR4 in Recognition of Gram-Negative and Gram-Positive Bacterial Cell Wall Components

1999 • 3,351 citations

Innate Immunity: The Virtues of a Nonclonal System of Recognition

1997 • 2,397 citations

The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between Toll-like receptors

2000 • 2,076 citations

A family of human receptors structurally related to Drosophila Toll

1998 • 1,735 citations

Peptidoglycan- and Lipoteichoic Acid-induced Cell Activation Is Mediated by Toll-like Receptor 2

1999 • 1,714 citations

Host Defense Mechanisms Triggered by Microbial Lipoproteins Through Toll-Like Receptors

1999 • 1,679 citations

Acute Bacterial Meningitis in Adults -- A Review of 493 Episodes

1993 • 1,321 citations

Cutting Edge: Recognition of Gram-Positive Bacterial Cell Wall Components by the Innate Immune System Occurs Via Toll-Like Receptor 2

1999 • 1,252 citations

Cutting Edge: TLR2-Deficient and MyD88-Deficient Mice Are Highly Susceptible toStaphylococcus aureusInfection

2000 • 1,046 citations

Streptococcus pneumoniae anchor to activated human cells by the receptor for platelet-activating factor

1995 • 754 citations

Toll-like Receptor 2 (TLR2) and TLR4 Differentially Activate Human Dendritic Cells

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Antigen presentation and tumor cytotoxicity by interferon‐γ‐treated microglial cells

1987 • 648 citations

Local production of tumor necrosis factor alpha, interleukin 1, and interleukin 6 in meningococcal meningitis. Relation to the inflammatory response.

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Pneumococcal trafficking across the blood-brain barrier. Molecular analysis of a novel bidirectional pathway.

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The role of cytokines in the generation of inflammation and tissue damage in experimental gram-positive meningitis.

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Reduction of inflammation, tissue damage, and mortality in bacterial meningitis in rabbits treated with monoclonal antibodies against adhesion-promoting receptors of leukocytes.

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The polarity of the dorsoventral axis in the drosophila embryo is defined by an extracellular signal

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Visualizing Pneumococcal Infections in the Lungs of Live Mice Using Bioluminescent Streptococcus pneumoniae Transformed with a Novel Gram-Positive lux Transposon

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The Relative Role of Bacterial Cell Wall and Capsule in the Induction of Inflammation in Pneumococcal Meningitis

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Cold‐induced brain edema and infarction are reduced in transgenic mice overexpressing CuZn‐Superoxide dismutase

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Circulating cell wall components derived from gram‐negative, not gram‐positive, bacteria cause a profound induction of the gene‐encoding Toll‐like receptor 2 in the CNS

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Relationship between Cell Surface Carbohydrates and Intrastrain Variation on Opsonophagocytosis ofStreptococcus pneumoniae

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Blood-Brain Barrier Damage in Patients with Bacterial Meningitis: Association with Tumor Necrosis Factor- but not Interleukin-I

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Cerebral endothelial cells release TNF-alpha after stimulation with cell walls of Streptococcus pneumoniae and regulate inducible nitric oxide synthase and ICAM-1 expression via autocrine loops.

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Pneumococcal Meningitis

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Anti ICAM-1 (CD 54) monoclonal antibody reduces inflammatory changes in experimental bacterial meningitis

1995 • 105 citations

A mouse model of Streptococcus pneumoniae meningitis mimicking several features of human disease

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The Free Radical Scavenger α‐Phenyl‐Tert‐Butyl Nitrone Aggravates Hippocampal Apoptosis and Learning Deficits in Experimental Pneumococcal Meningitis

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Enhanced attenuation of meningeal inflammation and brain edema by concomitant administration of anti-CD18 monoclonal antibodies and dexamethasone in experimental Haemophilus meningitis.

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Effect of Deficiency of Tumor Necrosis Factor Alpha or Both of Its Receptors onStreptococcus pneumoniaeCentral Nervous System Infection and Peritonitis

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The cell wall mediates pneumococcal attachment to and cytopathology in human endothelial cells

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Brain injury in bacterial meningitis

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Pneumococcal cell wall components induce nitric oxide synthase and TNF-α in astroglial-enriched cultures

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A Method for Obtaining Cerebrospinal Fluid from Mice

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Treatment with a monoclonal antibody to IL-8 attenuates the pleocytosis in experimental pneumococcal meningitis in rabbits when given intravenously, but not intracisternally

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Role of tumor necrosis factor alpha (cachectin) in experimental and clinical bacterial meningitis

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