Anti-CD28 Monoclonal Antibody Therapy Prevents Chronic Rejection of Renal Allografts in Rats

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

CTLA4-Ig and anti-CD40 ligand prevent renal allograft rejection in primates

1997 • 936 citations

The Emerging Role of CTLA-4 as an Immune Attenuator

1997 • 637 citations

The Role of T-Cell Costimulatory Activation Pathways in Transplant Rejection

1998 • 585 citations

Induction of alloantigen-specific hyporesponsiveness in human T lymphocytes by blocking interaction of CD28 with its natural ligand B7/BB1.

1993 • 494 citations

Co-stimulation in T cell responses

1997 • 430 citations

Chronic allograft nephropathy: An update

1999 • 367 citations

Direct and indirect recognition: the role of MHC antigens in graft rejection

1999 • 347 citations

Contributions of Direct and Indirect T Cell Alloreactivity During Allograft Rejection in Mice

1999 • 303 citations

INDIRECT ALLORECOGNITION OF MAJOR HISTOCOMPATIBILITY COMPLEX ALLOPEPTIDES IN HUMAN RENAL TRANSPLANT RECIPIENTS WITH CHRONIC GRAFT DYSFUNCTION1

1997 • 290 citations

In vivo blockade of CD28/CTLA4: B7/BB1 interaction with CTLA4-Ig reduces lethal murine graft-versus-host disease across the major histocompatibility complex barrier in mice

1994 • 245 citations

CYTOKINES, ADHESION MOLECULES, AND THE PATHOGENESIS OF CHRONIC REJECTION OF RAT RENAL ALLOGRAFTS

1993 • 218 citations

Molecular cloning of rat interleukin 4 cDNA and analysis of the cytokine repertoire of subsets of CD4⁺ T cells

1991 • 218 citations

Molecular regulation of interleukin‐2 expression by CD28 co‐stimulation and anergy

1998 • 190 citations

CD28‐mediated induction of proliferation in resting T cells in vitro and in vivo without engagement of the T cell receptor: Evidence for functionally distinct forms of CD28

1997 • 171 citations

Blockade of T-cell costimulation prevents development of experimental chronic renal allograft rejection.

1996 • 170 citations

Renin-angiotensin blockade lowers MCP-1 expression in diabetic rats

1999 • 154 citations

Late blockade of T cell costimulation interrupts progression of experimental chronic allograft rejection.

1998 • 129 citations

Chronic allograft dysfunction: mechanisms and new approaches to therapy.

2000 • 128 citations

Proinflammatory gene expression and macrophage recruitment in the rat remnant kidney

2000 • 116 citations

CTLA4-Ig: a novel immunosuppressive agent

2000 • 107 citations

PREVENTION OF CHRONIC REJECTION IN MOUSE AORTIC ALLOGRAFTS BY COMBINED TREATMENT WITH CTLA4-Ig AND ANTI-CD40 LIGAND MONOCLONAL ANTIBODY1,2

1997 • 96 citations

Th1/Th2 cytokine gene expression after mercuric chloride in susceptible and resistant rat strains

1996 • 66 citations

B7 costimulation is necessary for the activation of the lytic function in cytotoxic T lymphocyte precursors.

1995 • 64 citations

Negative regulation of T cell activation

1998 • 64 citations

PROLONGED ALLOGRAFT SURVIVAL BUT NO TOLERANCE INDUCTION BY MODULATING CD28 ANTIBODY JJ319 AFTER HIGH-RESPONDER RAT HEART TRANSPLANTATION1

1999 • 62 citations

T-CELL COSTIMULATORY BLOCKADE IN EXPERIMENTAL CHRONIC CARDIAC ALLOGRAFT REJECTION

1997 • 59 citations

Blockade of T Cell Costimulation by CTLA4-Ig Inhibits Lung Inflammation in Murine Hypersensitivity Pneumonitis

1999 • 59 citations

ROLE OF INDIRECT ALLORECOGNITION IN EXPERIMENTAL LATE ACUTE REJECTION1,2

1997 • 58 citations

Cellular distribution and costimulatory function of rat CD28. Regulated expression during thymocyte maturation and induction of cyclosporin A sensitivity of costimulated T cell responses by phorbol ester.

1995 • 52 citations

Direct and indirect pathways of alloantigen recognition: relevance to acute and chronic allograft rejection

1997 • 39 citations

SOLUBLE CTLA4Ig MODIFIES PARAMETERS OF ACUTE INFLAMMATION IN RAT LUNG ALLOGRAFT REJECTION WITHOUT ALTERING LYMPHOCYTIC INFILTRATION OR TRANSCRIPTION OF KEY CYTOKINES1

1995 • 31 citations

Topical CTLA4–Ig Suppresses Ongoing Mucosal Immune Response in Presensitized Murine Model of Allergic Rhinitis

1999 • 29 citations

Clonotype Analysis of Human Alloreactive T Cells: A Novel Approach to Studying Peripheral Tolerance in a Transplant Recipient

2000 • 28 citations

Blockade of the B7‐CD28 Pathway by CTLA4–Ig Counteracts Rejection and Prolongs Survival in Small Bowel Transplantation

2000 • 17 citations

Evidence of Indirect Allorecognition in Long-Term Human Renal Transplantation

1999 • 16 citations

CTLA4-Ig treatment prolongs rat orthotopic liver graft survival

1997 • 15 citations

In situ expression of cell growth factors in human renal chronic graft rejection

1997 • 7 citations

CD28-B7 T-CELL CO-STIMULATORY BLOCKADE POTENTIATES THE EFFECTS OF INTRATHYMIC IMMUNOMODULATION IN SENSITIZED GRAFT RECIPIENTS1,2

1997 • 4 citations