Relative Neutralizing Activity in Polyspecific IgM, IgA, and IgG Preparations against Group A Streptococcal Superantigens

The Pathogenesis of Sepsis

1991 • 1,376 citations

Kawasaki Disease

1995 • 1,225 citations

Invasive Group A Streptococcus Infections

1992 • 710 citations

Manipulating the Immune System with Immune Globulin

1992 • 649 citations

Superantigens and Their Potential Role in Human Disease

1993 • 620 citations

Defining the Group A Streptococcal Toxic Shock Syndrome

1993 • 610 citations

Clinical and Bacteriologic Observations of a Toxic Shock–like Syndrome Due toStreptococcus pyogenes

1987 • 581 citations

Intravenous Immunoglobulin Therapy for Streptococcal Toxic Shock Syndrome—A Comparative Observational Study

1999 • 537 citations

Staphylococcal and Streptococcal Pyrogenic Toxins Involved in Toxic Shock Syndrome and Related Illnesses

1990 • 477 citations

Role of Superantigens in Human Disease

1993 • 347 citations

Aspects of Pathogenesis of Serious Group A Streptococcal Infections in Sweden, 1988-1989

1992 • 303 citations

Bacterial pyrogenic exotoxins as superantigens

1995 • 281 citations

Severe Invasive Group A Streptococcal Infections In Ontario, Canada: 1987-1991

1993 • 251 citations

Intravenous Immunoglobulin Therapy for Toxic Shock Syndrome

1992 • 241 citations

Mechanisms of action of intravenous immune globulin in immune-mediated diseases

1996 • 203 citations

Identification and Characterization of Novel Superantigens from Streptococcus pyogenes

1999 • 195 citations

Plasma from patients with severe invasive group A streptococcal infections treated with normal polyspecific IgG inhibits streptococcal superantigen-induced T cell proliferation and cytokine production.

1996 • 184 citations

Bacterial Toxin‐Induced Cytokine Production Studied at the Single‐Cell Level

1992 • 164 citations

Mechanisms of action of intravenous immune serum globulin in autoimmune and inflammatory diseases

1997 • 163 citations

A novel superantigen isolated from pathogenic strains of Streptococcus pyogenes with aminoterminal homology to staphylococcal enterotoxins B and C.

1993 • 157 citations

Risk Factors in the Pathogenesis of Invasive Group A Streptococcal Infections: Role of Protective Humoral Immunity

1999 • 142 citations

Clinical Usefulness of Intravenous Human Immunoglobulins in Invasive Group A Streptococcal Infections: Case Report and Review

1995 • 131 citations

Invasive Group A Streptococcal Infections: T1M1 Isolates Expressing Pyrogenic Exotoxins A and B in Combination with Selective Lack of Toxin‐Neutralizing Antibodies Are Associated with Increased Risk of Streptococcal Toxic Shock Syndrome

1999 • 116 citations

Evidence for the presence of streptococcal-superantigen-neutralizing antibodies in normal polyspecific immunoglobulin G

1996 • 114 citations

Host Defense Dysfunction in Trauma, Shock and Sepsis

1993 • 111 citations

Molecular epidemiologic analysis of the type A streptococcal exotoxin (erythrogenic toxin) gene (speA) in clinical Streptococcus pyogenes strains

1989 • 105 citations

Varying Titers of Neutralizing Antibodies to Streptococcal Superantigens in Different Preparations of Normal Polyspecific Immunoglobulin G: Implications for Therapeutic Efficacy

1998 • 100 citations

Relation Between Low Capacity Of Human Sera To Inhibit Streptococcal Mitogens And Serious Manifestation Of Disease

1994 • 99 citations

Bacterial lipopolysaccharide (LPS)-specific antibodies in commercial human immunoglobulin preparations: superior antibody content of an IgM-enriched product

1998 • 82 citations

Streptococcal mitogenic exotoxin Z, a novel acidic superantigenic toxin produced by a T1 strain of Streptococcus pyogenes

1997 • 78 citations

Similar cytokine induction profiles of a novel streptococcal exotoxin, MF, and pyrogenic exotoxins A and B

1994 • 78 citations

Lymphokine production induced by streptococcal pyrogenic exotoxin‐A is selectively down‐regulated by pooled human IgG

1994 • 77 citations

Analysis of the superantigenic activity of mutant and allelic forms of streptococcal pyrogenic exotoxin A

1996 • 76 citations

Immunoglobulins to Group A Streptococcal Surface Molecules Decrease Adherence to and Invasion of Human Pharyngeal Cells

1998 • 71 citations

Adjunctive Treatment of Streptococcal Toxic Shock Syndrome Using Intravenous Immunoglobulin: Case Report and Review

1997 • 71 citations

Comparison of two types of intravenous immunoglobulins in the treatment of neonatal sepsis

1995 • 69 citations

T cell activation and cytokine release in streptococcal toxic shock-like syndrome

1993 • 67 citations

Bone Marrow Transplantation

1993 • 63 citations

Opsonic Antibodies to the Surface M Protein of Group A Streptococci in Pooled Normal Immunoglobulins (IVIG): Potential Impact on the Clinical Efficacy of IVIG Therapy for Severe Invasive Group A Streptococcal Infections

1998 • 60 citations

Differential induction of Th1 versus Th2 cytokines by group A streptococcal toxic shock syndrome isolates

1997 • 55 citations

Role of superantigens in the pathogenesis of infectious diseases and their sequelae

1992 • 47 citations

Use of IgM enriched intravenous immunoglobulin (Pentaglobin) in bone marrow transplantation.

1992 • 43 citations

Novel therapies in streptococcal toxic shock syndrome

1998 • 23 citations

Antiendotoxic Therapy with Polyclonal and Polyvalent Immunoglobulins: In Vitro and In Vivo Studies

1993 • 9 citations