The Hepatocyte Growth Factor Regulatory Factors in Human Breast Cancer

High levels of urokinase-type plasminogen activator and its inhibitor PAI-1 in cytosolic extracts of breast carcinomas are associated with poor prognosis.

1993 • 396 citations

Activation of Hepatocyte Growth Factor and Urokinase/Plasminogen Activator by Matriptase, an Epithelial Membrane Serine Protease

2000 • 394 citations

Molecular cloning and sequence analysis of the cDNA for a human serine protease reponsible for activation of hepatocyte growth factor. Structural similarity of the protease precursor to blood coagulation factor XII

1993 • 373 citations

Overexpression of the c-MET/HGF receptor gene in human thyroid carcinomas.

1992 • 317 citations

Immunoreactive hepatocyte growth factor is a strong and independent predictor of recurrence and survival in human breast cancer.

1994 • 301 citations

Induction of Hepatocyte Growth Factor in Fibroblasts by Tumor-derived Factors Affects Invasive Growth of Tumor Cells : In Vitro Analysis of Tumor-Stromal Interactions

1998 • 291 citations

Hepatocyte Growth Factor Activator Inhibitor, a Novel Kunitz-type Serine Protease Inhibitor

1997 • 271 citations

Expression of the Met/hepatocyte growth factor receptor in human pancreatic cancer.

1995 • 267 citations

Hepatocyte growth factor/scatter factor, its molecular, cellular and clinical implications in cancer

1999 • 266 citations

Coexpression of hepatocyte growth factor and receptor (Met) in human breast carcinoma.

1996 • 240 citations

Tissue microarray analysis of hepatocyte growth factor/Met pathway components reveals a role for Met, matriptase, and hepatocyte growth factor activator inhibitor 1 in the progression of node-negative breast cancer.

2003 • 231 citations

Proteolytic activation of hepatocyte growth factor in response to tissue injury.

1994 • 221 citations

Expression of c-met is a strong independent prognostic factor in breast carcinoma

1998 • 210 citations

Overexpression of theMET/HGF receptor in ovarian cancer

1994 • 207 citations

The TPR-MET oncogenic rearrangement is present and expressed in human gastric carcinoma and precursor lesions.

1991 • 190 citations

Matriptase and HAI-1 Are Expressed by Normal and Malignant Epithelial Cells in Vitro and in Vivo

2001 • 188 citations

Purification and Cloning of Hepatocyte Growth Factor Activator Inhibitor Type 2, a Kunitz-type Serine Protease Inhibitor

1997 • 188 citations

Urokinase and plasminogen activator inhibitor type 1 in pulmonary adenocarcinoma

1994 • 169 citations

Expression of peroxisome‐proliferator activated receptor‐gamma (PPARγ) and the PPARγ co‐activator, PGC‐1, in human breast cancer correlates with clinical outcomes

2003 • 164 citations

Met expression is associated with poor outcome in patients with axillary lymph node negative breast carcinoma

1999 • 156 citations

Expression of the C-Met/HGF receptor in human breast carcinoma: Correlation with tumor progression

1997 • 153 citations

Activation of hepatocyte growth factor/scatter factor in colorectal carcinoma.

2000 • 128 citations

Elevated HGF Levels in Sera from Breast Cancer Patients Detected Using a Protein Microarray ELISA

2002 • 127 citations

Hepatocyte Growth Factor Activator Inhibitor Type 1 Is a Specific Cell Surface Binding Protein of Hepatocyte Growth Factor Activator (HGFA) and Regulates HGFA Activity in the Pericellular Microenvironment

2000 • 126 citations

Plasmin/Plasminogen System in Colorectal Cancer

2002 • 121 citations

Tumor-associated proteolysis and prognosis: new functional risk factors in gastric cancer defined by the urokinase-type plasminogen activator system.

1995 • 116 citations

Hepatocyte Growth Factor Stimulates Proliferation, Migration, and Lumen Formation of Human Endometrial Epithelial Cells in Vitro

1997 • 113 citations

Serum concentrations of hepatocyte growth factor in breast cancer patients.

1995 • 104 citations

Expression of hepatocyte growth factor/scatter factor, its activator, inhibitors and the c-Met receptor in human cancer cells.

2001 • 99 citations

The role of hepatocyte growth factor (scatter factor) in epithelialmesenchymal transition and breast cancer

2002 • 93 citations

Significance of circulating hepatocyte growth factor level as a prognostic indicator in primary breast cancer.

1998 • 86 citations

Serum hepatocyte growth factor as an index of disease status of patients with colorectal carcinoma

1998 • 81 citations

Expression of urokinase-type plasminogen activator (uPA) and its inhibitor PAI-1 in benign, borderline, malignant primary and metastatic ovarian tumors

1996 • 68 citations

Tumor-associated proteases and inhibitors in gastric cancer: analysis of prognostic impact and individual risk protease patterns.

1997 • 68 citations

Functional Characterization of Kunitz Domains in Hepatocyte Growth Factor Activator Inhibitor Type 1

2002 • 64 citations

Quantitative analysis of lymphangiogenic markers in human colorectal cancer

2003 • 60 citations

Expression of hepatocyte growth factor/scatter factor, its activator, inhibitors and the c-Met receptor in human cancer cells

2001 • 60 citations

Scatter factor protein levels in human breast cancers: clinicopathological and biological correlations.

1996 • 56 citations

Cloning of a new Kunitz-type protease inhibitor with a putative transmembrane domain overexpressed in pancreatic cancer

1998 • 50 citations

Met protein and hepatocyte growth factor (HGF) in papillary carcinoma of the thyroid: evidence for a pathogenetic role in tumourigenesis

2001 • 48 citations

Progression-linked overexpression of c-Met in prostatic intraepithelial neoplasia and latent as well as clinical prostate cancers

1999 • 48 citations

Multiple Sites of Proteolytic Cleavage to Release Soluble Forms of Hepatocyte Growth Factor Activator Inhibitor Type 1 from a Transmembrane Form

1999 • 47 citations

Suppression of urokinase receptor expression by bikunin is associated with inhibition of upstream targets of extracellular signal‐regulated kinase‐dependent cascade

2002 • 45 citations

Upregulation of HGF activator inhibitor type 1 but not type 2 along with regeneration of intestinal mucosa

2000 • 41 citations

Emerging multifunctional aspects of cellular serine proteinase inhibitors in tumor progression and tissue regeneration

2002 • 38 citations

Alteration of Met protooncogene product expression and prognosis in breast carcinomas.

1999 • 36 citations

Conserved expression of hepatocyte growth factor activator inhibitor type-2/placental bikunin in human colorectal carcinomas

2000 • 31 citations

Expression of Hepatocyte Growth Factor Activator and Hepatocyte Growth Factor Activator Inhibitor Type 1 in Human Hepatocellular Carcinoma

2001 • 27 citations

INCREASE IN THE CIRCULATING LEVEL OF HEPATOCYTE GROWTH-FACTOR IN BREAST-CANCER PATIENTS WITH DISTANT METASTASES

1994 • 5 citations

[Hepatocyte growth factor in the sera of patients with gastrointestinal and breast cancer].

1997 • 4 citations

Increased concentration of hepatocyte growth factor in the sera of patients with gastrointestinal cancer

1997 • 3 citations

Deleted Work

1955 • 0 citations

Cited By (0)

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