Is the R and R∗ dichotomy real?

A mutation-induced activated state of the beta 2-adrenergic receptor. Extending the ternary complex model.

1993 • 1,213 citations

Differential signal transduction by five splice variants of the PACAP receptor

1993 • 1,185 citations

Agonist-receptor efficacy II: agonist trafficking of receptor signals

1995 • 637 citations

The two-state model of receptor activation

1995 • 492 citations

Constitutively active mutants of the alpha 1B-adrenergic receptor: role of highly conserved polar amino acids in receptor activation.

1996 • 377 citations

Diversity and Selectivity of Receptor-G Protein Interaction

1996 • 365 citations

Detection, quantitation, and verification of allosteric interactions of agents with labeled and unlabeled ligands at G protein-coupled receptors: interactions of strychnine and acetylcholine at muscarinic receptors.

1995 • 259 citations

THE INHIBITORY EFFECT OF GALLAMINE ON MUSCARINIC RECEPTORS

1976 • 249 citations

Agonist-specific coupling of a cloned Drosophila octopamine/tyramine receptor to multiple second messenger systems.

1994 • 243 citations

Positive Cooperativity of Acetylcholine and Other Agonists with Allosteric Ligands on Muscarinic Acetylcholine Receptors

1997 • 222 citations

Constitutive activation of a single effector pathway: evidence for multiple activation states of a G protein-coupled receptor.

1996 • 188 citations

The Cubic Ternary Complex Receptor–Occupancy Model I. Model Description

1996 • 186 citations

Agonist-receptor efficacy I: mechanisms of efficacy and receptor promiscuity

1995 • 172 citations

Allosteric modulation of muscarinic acetylcholine receptors

1995 • 155 citations

Is there a ‘lock’ for all agonist ‘keys’ in 7TM receptors?

1996 • 130 citations

Discrete activation of transduction pathways associated with acetylcholine m1 receptor by several muscarinic ligands

1994 • 126 citations

Two allosteric modulators interact at a common site on cardiac muscarinic receptors.

1992 • 82 citations

Inverse agonism: theory and practice

1995 • 80 citations

Pharmacological proteus?

1995 • 80 citations

Molecular Mechanisms Involved in Muscarinic Acetylcholine Receptor-mediated G Protein Activation Studied by Insertion Mutagenesis

1996 • 77 citations

Receptor conformational induction versus selection: all part of the same energy landscape

1996 • 70 citations

Positive cooperativity in the binding of alcuronium and N-methylscopolamine to muscarinic acetylcholine receptors.

1990 • 70 citations

Identification of drugs competing with d-tubocurarine for an allosteric site on cardiac muscarinic receptors.

1994 • 60 citations

Porcine m2 Muscarinic Acetylcholine Receptor-Effector Coupling in Chinese Hamster Ovary Cells

1995 • 46 citations

Competition between positive and negative allosteric effectors on muscarinic receptors.

1995 • 42 citations

Functional epitope analysis of the second extracellular loop of the human heart muscarinic acetylcholine receptor

1995 • 38 citations

Allosteric regulation of G-protein-linked receptors

1995 • 32 citations

Allosteric regulation of the binding of [3H]acetylcholine to m2 muscarinic receptors

1996 • 24 citations

Positive allosteric action of eburnamonine on cardiac muscarinic acetylcholine receptors

1996 • 18 citations

Allosteric interactions between alcuronium and ligands binding to the classical binding site on cardiac muscarinic receptors

1995 • 7 citations

Single amino acid substitutions in the pm2 muscarinic receptor alter receptor/G protein coupling without changing physiological responses.

1996 • 6 citations

Allosteric ligand-receptor-G protein interactions in lipid vesicles

1997 • 3 citations