A high-throughput screen for identification of molecular mimics of Smac/DIABLO utilizing a fluorescence polarization assay

A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays

1999 • 6,580 citations

Smac, a Mitochondrial Protein that Promotes Cytochrome c–Dependent Caspase Activation by Eliminating IAP Inhibition

2000 • 3,415 citations

Identification of DIABLO, a Mammalian Protein that Promotes Apoptosis by Binding to and Antagonizing IAP Proteins

2000 • 2,344 citations

Death and anti-death: tumour resistance to apoptosis

2002 • 1,963 citations

IAP proteins: blocking the road to death's door

2002 • 1,753 citations

Mechanisms of Caspase Activation and Inhibition during Apoptosis

2002 • 1,731 citations

Induction of Apoptosis by Cancer Chemotherapy

2000 • 1,239 citations

Caspase Cleaved BID Targets Mitochondria and Is Required for Cytochrome c Release, while BCL-XL Prevents This Release but Not Tumor Necrosis Factor-R1/Fas Death

1999 • 1,024 citations

A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosis

2001 • 987 citations

Structural basis of IAP recognition by Smac/DIABLO

2000 • 844 citations

Structural and biochemical basis of apoptotic activation by Smac/DIABLO

2000 • 842 citations

Smac agonists sensitize for Apo2L/TRAIL- or anticancer drug-induced apoptosis and induce regression of malignant glioma in vivo

2002 • 739 citations

Mechanism of XIAP-Mediated Inhibition of Caspase-9

2003 • 675 citations

Structural basis for binding of Smac/DIABLO to the XIAP BIR3 domain

2000 • 625 citations

Expression and prognostic significance of IAP-family genes in human cancers and myeloid leukemias.

2000 • 617 citations

Identification of small-molecule inhibitors of interaction between the BH3 domain and Bcl-xL

2001 • 546 citations

Mechanisms of apoptosis avoidance in cancer

1999 • 371 citations

Molecular Determinants of the Caspase-promoting Activity of Smac/DIABLO and Its Role in the Death Receptor Pathway

2000 • 352 citations

The serine protease Omi/HtrA2 is released from mitochondria during apoptosis. Omi interacts with caspase-inhibitor XIAP and induces enhanced caspase activity

2002 • 349 citations

Inhibitor of apoptosis proteins and their relatives: IAPs and other BIRPs.

2001 • 329 citations

Fluorescence Polarization and Anisotropy in High Throughput Screening: Perspectives and Primer

2000 • 289 citations

NMR Structure and Mutagenesis of the Third Bir Domain of the Inhibitor of Apoptosis Protein XIAP

2000 • 258 citations

Predominant suppression of apoptosome by inhibitor of apoptosis protein in non-small cell lung cancer H460 cells: therapeutic effect of a novel polyarginine-conjugated Smac peptide.

2003 • 238 citations

Development of High Throughput Screening Assays Using Fluorescence Polarization: Nuclear Receptor-Ligand–Binding and Kinase /Phosphatase Assays

2000 • 202 citations

Mutations in apoptosis genes: a pathogenetic factor for human disease

2001 • 163 citations

SMAC Negatively Regulates the Anti-apoptotic Activity of Melanoma Inhibitor of Apoptosis (ML-IAP)

2002 • 161 citations

High-throughput screening: advances in assay technologies

1997 • 145 citations

Oligomerization and activation of caspase-9, induced by Apaf-1 CARD

2002 • 143 citations

Fluorescence Polarization: An Analytical Tool for Immunoassay and_ Drug Discovery

1999 • 118 citations

Expression and location of pro-apoptotic Bcl-2 family protein BAD in normal human tissues and tumor cell lines.

1998 • 113 citations

A small-molecule inhibitor of the ribonucleolytic activity of human angiogenin that possesses antitumor activity

2002 • 111 citations

Molecular Targeting of Inhibitor of Apoptosis Proteins Based on Small Molecule Mimics of Natural Binding Partners

2002 • 102 citations

High Throughput Fluorescence Polarization: A Homogeneous Alternative to Radioligand Binding for Cell Surface Receptors

2000 • 99 citations

Application of High-Throughput, Molecular-Targeted Screening to Anticancer Drug Discovery

2002 • 91 citations

A conserved tetrapeptide motif: potentiating apoptosis through IAP-binding

2002 • 90 citations

A High-Throughput STAT Binding Assay Using Fluorescence Polarization

1997 • 62 citations

Fluorescence Polarization Assays for High Throughput Screening of G Protein–Coupled Receptors

2000 • 43 citations

Considerations for Using Fluorescence Polarization in the Screening of G Protein-Coupled Receptors

2002 • 35 citations

Homogeneous Cell-Based Fluorescence Polarization Assay for the Direct Detection of cAMP

2001 • 28 citations

Sulfonic acid dyes: inhibition of the human immunodeficiency virus and mechanism of action.

1992 • 25 citations

Analysis of Protein–Peptide Interaction by a Miniaturized Fluorescence Polarization Assay Using Cyclin-Dependent Kinase 2/Cyclin E as a Model System

1999 • 19 citations

A High-Throughput Fluorescent Polarization Assay for Nuclear Receptor Binding Utilizing Crude Receptor Extract

2002 • 17 citations

Sulfonic Acid Dyes

1992 • 16 citations

The Integration of High Throughput Technologies for Drug Discovery

2001 • 8 citations