Estrogen receptor alpha mediates the proliferative but not the cytotoxic dose-dependent effects of two major phytoestrogens on human breast cancer cells.

Comparison of the Ligand Binding Specificity and Transcript Tissue Distribution of Estrogen Receptors α and β

1997 • 4,422 citations

Case 39-2000

2000 • 3,891 citations

Genistein, a specific inhibitor of tyrosine-specific protein kinases.

1987 • 3,773 citations

Meta-Analysis of the Effects of Soy Protein Intake on Serum Lipids

1995 • 2,096 citations

Cancer statistics, 1996

1996 • 1,807 citations

Functional domains of the human estrogen receptor

1987 • 1,316 citations

Structural Determinants of Phosphoinositide 3-Kinase Inhibition by Wortmannin, LY294002, Quercetin, Myricetin, and Staurosporine

2000 • 1,121 citations

Activation of the unliganded estrogen receptor by EGF involves the MAP kinase pathway and direct phosphorylation.

1996 • 992 citations

Structure of the ligand-binding domain of oestrogen receptor beta in the presence of a partial agonist and a full antagonist

1999 • 963 citations

Genistein, a dietary-derived inhibitor of in vitro angiogenesis.

1993 • 777 citations

Differential Response of Estrogen Receptor α and Estrogen Receptor β to Partial Estrogen Agonists/Antagonists

1998 • 776 citations

Case-control study of phyto-oestrogens and breast cancer

1997 • 738 citations

Exposure of infants to phyto-oestrogens from soy-based infant formula

1997 • 715 citations

Estrogenic effects of genistein on the growth of estrogen receptor-positive human breast cancer (MCF-7) cells in vitro and in vivo.

1998 • 601 citations

Inhibitory effects of the tyrosine kinase inhibitor genistein on mammalian DNA topoisomerase II.

1989 • 559 citations

Phytoestrogens: epidemiology and a possible role in cancer protection.

1995 • 558 citations

Soybean phytoestrogen intake and cancer risk.

1995 • 552 citations

Genistein inhibition of the growth of human breast cancer cells: Independence from estrogen receptors and the multi-drug resistance gene

1991 • 467 citations

Naturally occurring oestrogens in foods—A review

1985 • 452 citations

The cloned human oestrogen receptor contains a mutation which alters its hormone binding properties.

1989 • 428 citations

Dietary flour supplementation decreases post-menopausal hot flushes: Effect of soy and wheat

1995 • 428 citations

Inhibition of tumor Promoter‐induced hydrogen peroxide formationin vitroandin vivoby genistein

1993 • 366 citations

Estrogen Receptor Activation Function 1 Works by Binding p160 Coactivator Proteins

1998 • 366 citations

Different activation domains stimulate transcription from remote (‘enhancer’) and proximal (‘promoter’) positions.

1992 • 359 citations

Effect of genistein on in vitro and in vivo models of cancer.

1995 • 349 citations

Antiproliferative potency of structurally distinct dietary flavonoids on human colon cancer cells

1996 • 323 citations

Two-Week Dietary Soy Supplementation Has an Estrogenic Effect on Normal Premenopausal Breast¹

1999 • 237 citations

Oestrogenic effects of plant foods in postmenopausal women.

1990 • 227 citations

Determination of lignans and isoflavonoids in human female plasma following dietary supplementation

1994 • 221 citations

Breast and Prostate Cancer: An Analysis of Common Epidemiological, Genetic, and Biochemical Features*

1998 • 200 citations

Evaluation of the biochemical targets of genistein in tumor cells.

1995 • 192 citations

Estradiol Hypersensitivity and Mitogen-Activated Protein Kinase Expression in Long-Term Estrogen Deprived Human Breast Cancer Cellsin Vivo¹

2000 • 164 citations

Adrenal androgens stimulate the proliferation of breast cancer cells as direct activators of estrogen receptor alpha.

1999 • 139 citations

Identification of Amino Acids in the Hormone Binding Domain of the Human Estrogen Receptor Important in Estrogen Binding

1996 • 110 citations

Quercetin Inhibits Heat Shock Protein Induction but Not Heat Shock Factor DNA-Binding in Human Breast Carcinoma Cells

1997 • 107 citations

Steroid Hormones, Receptors, and Antagonists

1996 • 91 citations

Type II oestrogen binding sites in acute lymphoid and myeloid leukaemias: growth inhibitory effect of oestrogen and flavonoids

1990 • 85 citations

Oligonucleotide Squelching Reveals the Mechanism of Estrogen Receptor Autologous Down-Regulation

1997 • 48 citations

Effect of ozone on respiratory responses in subjects with asthma.

1995 • 47 citations

A Non-Radioactive Method for Inexpensive Quantitative RT-PCR

1999 • 35 citations

Steroid Hormone Antagonists Summary and Future Challenges

1995 • 27 citations

Growth inhibition by anti-estrogens and progestins in TGF-β-resistant and -sensitive breast-tumor cells

1996 • 20 citations