Immunoglobulin heavy-chain enhancer is required to maintain transfected gamma 2A gene expression in a pre-B-cell line.

Molecular Cloning: A Laboratory Manual

2001 • 133,517 citations

Transformation of mammalian cells to antibiotic resistance with a bacterial gene under control of the SV40 early region promoter.

1982 • 2,753 citations

A lymphocyte-specific cellular enhancer is located downstream of the joining region in immunoglobulin heavy chain genes

1983 • 1,449 citations

A tissue-specific transcription enhancer element is located in the major intron of a rearranged immunoglobulin heavy chain gene

1983 • 1,418 citations

Selection for animal cells that express the Escherichia coli gene coding for xanthine-guanine phosphoribosyltransferase.

1981 • 1,048 citations

Enhancer-dependent expression of human kappa immunoglobulin genes introduced into mouse pre-B lymphocytes by electroporation.

1984 • 889 citations

Expression of a Bacterial Gene in Mammalian Cells

1980 • 788 citations

Cell-type specificity of iminunoglobulin gene expression is regulated by at least three DNA sequence elements

1985 • 588 citations

Expression and regulation of immunoglobulin heavy chain gene transfected into lymphoid cells.

1983 • 457 citations

Regulation of Genome Rearrangement Events during Lymphocyte Differentiation

1986 • 422 citations

Immunoglobulin gene expression in transformed lymphoid cells.

1983 • 400 citations

Transcription cell type specificity is conferred by an immunoglobulin VH gene promoter that includes a functional consensus sequence

1985 • 313 citations

Immunoglobulin Heavy-Chain Enhancer Requires One or More Tissue-Specific Factors

1985 • 271 citations

The role of the κ enhancer and its binding factor NF-κB in the developmental regulation of κ gene transcription

1987 • 247 citations

5′ Flanking region of immunoglobulin heavy chain constant region genes displays length heterogeneity in germlines of inbred mouse strains

1980 • 238 citations

The immunoglobulin kappa locus contains a second, stronger B-cell-specific enhancer which is located downstream of the constant region.

1989 • 213 citations

Developmental stage specificity of the lymphoid V(D)J recombination activity.

1987 • 199 citations

Immunoglobulin heavy-chain expression and class switching in a murine leukaemia cell line

1982 • 173 citations

Expression of immunoglobulin heavy chain at a high level in the absence of a proposed immunoglobulin enhancer element in cis.

1984 • 135 citations

High-Frequency Transfer of Cloned Herpes Simplex Virus Type 1 Sequences to Mammalian Cells by Protoplast Fusion

1981 • 133 citations

Deletion of the IgH enhancer does not reduce immunoglobulin heavy chain production of a hybridoma IgD class switch variant.

1984 • 127 citations

A developmental-specific factor binds to suppressor sites flanking the immunoglobulin heavy-chain enhancer.

1989 • 116 citations

During B-cell differentiation enhancer activity and transcription rate of immunoglobulin heavy chain genes are high before mRNA accumulation

1986 • 105 citations

Deletion of a B-cell-specific enhancer affects transfected, but not endogenous, immunoglobulin heavy-chain gene expression.

1985 • 92 citations

Independent immunoglobulin class-switch events occurring in a single myeloma cell line.

1985 • 81 citations

Transcriptional regulation of immunoglobulin V genes

1981 • 81 citations

Site-specific recombination between immunoglobulin D and JH segments that were introduced into the genome of a murine pre-B cell line

1984 • 77 citations

Characterization of immunoglobulin enhancer deletions in murine plasmacytomas.

1985 • 72 citations

SV40 enhancer-binding factors are required at the establishment but not the maintenance step of enhancer-dependent transcriptional activation

1986 • 56 citations

A hit-and-run mechanism for transcriptional activation?

1988 • 50 citations

Stable propagation of the active transcriptional state of an immunoglobulin μ gene requires continuous enhancer function

1988 • 48 citations

Evidence for transient requirement of the IgH enhancer

1985 • 46 citations

Site of unequal sister chromatid exchange contains a potential Z-DNA-forming tract.

1988 • 46 citations

Unequal sister chromatid exchange. A mechanism affecting Ig gene arrangement and expression.

1985 • 40 citations

DNA rearrangements in MPC-11 immunoglobulin heavy chain class-switch variants.

1982 • 39 citations

Induction of light chain expression in a pre-B cell line by fusion to myeloma cells

1981 • 32 citations

Primary and secondary variants in immunoglobulin heavy chain production

1976 • 31 citations