Fluorescent Probes of Cell Signaling

A new generation of Ca2+ indicators with greatly improved fluorescence properties.

1985 • 21,873 citations

Ionic channels of excitable membranes

1985 • 7,199 citations

Calcium homeostasis in intact lymphocytes: cytoplasmic free calcium monitored with a new, intracellularly trapped fluorescent indicator.

1982 • 2,255 citations

Intracellular pH measurements in Ehrlich ascites tumor cells utilizing spectroscopic probes generated in situ

1979 • 2,166 citations

Multiple Calcium Channels and Neuronal Function

1987 • 1,336 citations

Functional architecture of cortex revealed by optical imaging of intrinsic signals

1986 • 1,246 citations

Calcium Action in Synaptic Transmitter Release

1987 • 742 citations

Measurement of Ca2+ concentrations in living cells

1982 • 664 citations

Measurement of cytosolic free Ca2+ in individual small cells using fluorescence microscopy with dual excitation wavelengths

1985 • 660 citations

Changes of free calcium levels with stages of the cell division cycle

1985 • 591 citations

Dye Indicators of Membrane Potential

1979 • 566 citations

Calcium Rises Abruptly and Briefly Throughout the Cell at the Onset of Anaphase

1986 • 541 citations

Lucifer dyes—highly fluorescent dyes for biological tracing

1981 • 513 citations

[14] Measurement of cytosolic free Ca2+ with quin2

1989 • 466 citations

Fura-2 measurement of cytosolic free Ca2+ in monolayers and suspensions of various types of animal cells.

1987 • 424 citations

Fluorescence ratio imaging: a new window into intracellular ionic signaling

1986 • 421 citations

Spectra, membrane binding, and potentiometric responses of new charge shift probes

1985 • 384 citations

The Ca signal from fura‐2 loaded mast cells depends strongly on the method of dye‐loading

1985 • 356 citations

Effect of Membrane Potential Changes on the Calcium Transient in Single Rat Cardiac Muscle Cells

1987 • 353 citations

Oscillations of cytosolic Ca2+ in pituitary cells due to action potentials

1987 • 331 citations

Kinetics of smooth and skeletal muscle activation by laser pulse photolysis of caged inositol 1,4,5-trisphosphate

1987 • 331 citations

The Use of a Charge-Coupled Device for Quantitative Optical Microscopy of Biological Structures

1987 • 302 citations

Sustained Dendritic Gradients of Ca ²⁺ Induced by Excitatory Amino Acids in CA1 Hippocampal Neurons

1988 • 301 citations

Defining Lipid Transport Pathways in Animal Cells

1985 • 294 citations

Spatial distribution of calcium channels and cytosolic calcium transients in growth cones and cell bodies of sympathetic neurons.

1988 • 294 citations

Optical mapping of electrical activity in rat somatosensory and visual cortex

1985 • 285 citations

Electrically and chemically mediated increases in intracellular calcium in neuronal growth cones

1987 • 284 citations

Optical imaging of cell membrane potential changes induced by applied electric fields

1986 • 273 citations

The effects of excitatory amino acids on intracellular calcium in single mouse striatal neurons in vitro

1987 • 268 citations

Magnesium as a regulatory cation: criteria and evaluation.

1987 • 268 citations

Depolarization- and transmitter-induced changes in intracellular Ca2+ of rat cerebellar granule cells in explant cultures

1987 • 258 citations

Biologically useful chelators that release Ca2+ upon illumination

1988 • 248 citations

The influence of intracellular calcium concentration on degranulation of dialysed mast cells from rat peritoneum.

1988 • 245 citations

The concentration of cytosolic free calcium in vertebrate rod outer segments measured with fura-2

1988 • 234 citations

Sequential activation and lethal hit measured by [Ca2+]i in individual cytolytic T cells and targets.

1987 • 231 citations

Using quin2 in cell suspensions

1985 • 180 citations

Estimation of intracellular chloride activity in isolated perfused rabbit proximal convoluted tubules using a fluorescent indicator

1988 • 162 citations

Cytosolic calcium transients from the beating mammalian heart.

1987 • 159 citations

Simultaneous recording of calcium transients in skeletal muscle using high- and low-affinity calcium indicators

1988 • 149 citations

Ca2+ binding kinetics of fura-2 and azo-1 from temperature-jump relaxation measurements

1988 • 146 citations

Digital image processing of intracellular pH in gastric oxyntic and chief cells

1987 • 145 citations

Real-time imaging of evoked activity in local circuits of the salamander olfactory bulb

1988 • 138 citations

Charge-shift probes of membrane potential. Characterization of aminostyrylpyridinium dyes on the squid giant axon

1985 • 137 citations

Light-flash physiology with synthetic photosensitive compounds.

1987 • 133 citations

The kinetics of calcium binding to fura‐2 and indo‐1

1987 • 130 citations

Sodium-activated potassium current in cultured avian neurones

1985 • 126 citations

Free calcium increases during anaphase in stamen hair cells of Tradescantia.

1987 • 119 citations

Resonance energy transfer microscopy: observations of membrane-bound fluorescent probes in model membranes and in living cells.

1986 • 105 citations

Transition from metaphase to anaphase is accompanied by local changes in cytoplasmic free calcium in Pt K2 kidney epithelial cells.

1986 • 103 citations

Measurement of cytosolic free magnesium ion concentration by fluorine-19 NMR

1988 • 89 citations

Fast intracellular pH determination in single cells by flow-cytometry

1981 • 89 citations

Optical recording of synaptic potentials from processes of single neurons using intracellular potentiometric dyes

1987 • 85 citations

Odor-elicited activity monitored simultaneously from 124 regions of the salamander olfactory bulb using a voltage-sensitive dye

1987 • 80 citations

Activity-dependent calcium transients in central nervous system myelinated axons revealed by the calcium indicator Fura-2

1987 • 71 citations

Fluorescence emission spectroscopy of 1,4-dihydroxyphthalonitrile. A method for determining intracellular pH in cultured cells

1985 • 67 citations

Flow cytometric analysis of murine splenic B lymphocyte cytosolic free calcium response to anti‐IgM and anti‐IgD

1987 • 62 citations

The Na+, K+ pump may mediate the control of nerve cells by nerve growth factor

1983 • 52 citations

Design and properties of a fluorescent indicator of intracellular free Na+ concentration

1988 • 44 citations

Tryptophan imaging of membrane proteins

1985 • 29 citations

Measurement of intracellular Ca2+ in the bullfrog sympathetic ganglion cells using fura-2 fluorescence

1988 • 23 citations

New tetracarboxylate chelators for fluorescence measurement and photochemical manipulation of cytosolic free calcium concentrations.

1986 • 17 citations

Optical studies of the mechanism of membrane potential sensitivity of merocyanine 540.

1986 • 10 citations

Membrane dynamics studied by fluorescence correlation spectroscopy and photobleaching recovery.

1986 • 10 citations

More light on brains

1988 • 8 citations

Optical Studies of Excitation and Secretion in Vertebrate Nerve Terminals

1986 • 8 citations

[51] Fluorescence as a probe of contractile systems

1982 • 6 citations

Optical determination of electrical properties of red blood cell and Ehrlich ascites tumor cell membranes with fluorescent dyes.

1986 • 4 citations