Activity of hepatocyte nuclear factor 1α and hepatocyte nuclear factor 1β isoforms is differently affected by the inhibition of protein phosphatases 1/2A
Data up to Jan 2025
Total Citations Per Year
Abstract
References (53)
Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease
1979 • 22,482 citations
THE STRUCTURE AND REGULATION OF PROTEIN PHOSPHATASES
1989 • 2,518 citations
Enterocyte-like differentiation and polarization of the human colon carcinoma cell line Caco-2 in culture
1983 • 1,765 citations
Mutations in the hepatocyte nuclear factor-1α gene in maturity-onset diabetes of the young (MODY3)
1996 • 1,607 citations
How NF-κB is activated: the role of the IκB kinase (IKK) complex
1999 • 1,133 citations
Effects of the tumour promoter okadaic acid on intracellular protein phosphorylation and metabolism
1989 • 848 citations
Hepatocyte Nuclear Factor 1 Inactivation Results in Hepatic Dysfunction, Phenylketonuria, and Renal Fanconi Syndrome
1996 • 574 citations
Interaction of a Liver-Specific Nuclear Factor with the Fibrinogen and α 1 -Antitrypsin Promoters
1987 • 485 citations
A transcriptional hierarchy involved in mammalian cell-type specification
1992 • 428 citations
Differential expression of sucrase-isomaltase in clones isolated from early and late passages of the cell line caco-2: Evidence for glucose-dependent negative regulation
1994 • 416 citations
Defective insulin secretion in hepatocyte nuclear factor 1alpha-deficient mice.
1998 • 319 citations
HNF-1, a member of a novel class of dimerizing homeodomain proteins.
1991 • 286 citations
Variant Hepatocyte Nuclear Factor 1 is required for visceral endoderm specification
1999 • 282 citations
vHNF1 is a homeoprotein that activates transcription and forms heterodimers with HNF1.
1991 • 276 citations
Laron Dwarfism and Non-Insulin-Dependent Diabetes Mellitus in the Hnf-1α Knockout Mouse
1998 • 251 citations
Essential role for the homeoprotein vHNF1/HNF1β in visceral endoderm differentiation
1999 • 231 citations
Tissue-specific expression of the gene encoding hepatocyte nuclear factor 1 may involve hepatocyte nuclear factor 4.
1991 • 192 citations
Analysis of the distribution of binding sites for a tissue-specific transcription factor in the vertebrate genome 1 1Edited by M. Gottesman
1997 • 180 citations
Protein Kinase A-Dependent Phosphorylation Modulates DNA-Binding Activity of Hepatocyte Nuclear Factor 4
1997 • 179 citations
The Structure And Regulation Of Protein Phosphatases
1989 • 142 citations
A variant nuclear protein in dedifferentiated hepatoma cells binds to the same functional sequences in the beta fibrinogen gene promoter as HNF-1.
1988 • 139 citations
More potent transcriptional activators or a transdominant inhibitor of the HNF1 homeoprotein family are generated by alternative RNA processing.
1993 • 126 citations
Phosphorylation of Proteasomes in Mammalian Cells
1996 • 125 citations
Novel DNA-Binding Proteins Regulate Intestine-Specific Transcription of the Sucrase-Isomaltase Gene
1992 • 118 citations
Circadian Periodicity of Intestinal Na+/Glucose Cotransporter 1 mRNA Levels Is Transcriptionally Regulated
1998 • 115 citations
Molecular Genetics of Maturity-onset Diabetes of the Young
1999 • 113 citations
Promoter elements and factors required for hepatic and intestinal transcription of the human ApoCIII gene.
1990 • 110 citations
Isolation of a cDNA probe for a human jejunal brush-border hydrolase, sucrase-isomaltase, and assignment of the gene locus to chromosome 3
1987 • 108 citations
Novel DNA-binding proteins regulate intestine-specific transcription of the sucrase-isomaltase gene.
1992 • 104 citations
Activation of NF-κB by Phosphatase Inhibitors Involves the Phosphorylation of IκBα at Phosphatase 2A-sensitive Sites
1995 • 96 citations
Inhibition of protein phosphatases by okadaic acid induces AP1 in human T cells
1991 • 94 citations
Anatomy of a Homeoprotein Revealed by the Analysis of Human MODY3 Mutations
1999 • 94 citations
Ubiquitin-Dependent Signaling: The Role of Ubiquitination in the Response of Cells to Their Environment.
1999 • 83 citations
Regulation of the human Na+-glucose cotransporter gene,SGLT1, by HNF-1 and Sp1
2000 • 80 citations
Naturally occurring mutations in the human HNF4alpha gene impair the function of the transcription factor to a varying degree
2000 • 75 citations
Positive Regulation of the vHNFl Promoter by the Orphan Receptors COUP-TFI/Ear3 and COUP-TFII/Arp1
1996 • 75 citations
A rapid microscale procedure for the simultaneous preparation of cytoplasmic RNA, nuclear DNA binding proteins and enzymatically active luciferase extracts
1991 • 71 citations
Phosphorylation of proteasomes in mammalian cells.
1999 • 58 citations
Reversible forskolin‐induced impairment of sucrase‐isomaltase mRNA levels, biosynthesis, and transport to the brush border membrane in Caco‐2 cells
1989 • 49 citations
Isolation of a cDNA probe for the human intestinal dipeptidylpeptidase IV and assignment of the gene locus DPP4 to chromosome 2
1990 • 38 citations
Biogenesis and Intracellular Transport of Intestinal Brush Border Membrane Hydrolases
1988 • 27 citations
Hypoxia and CYP1A1 induction-dependent regulation of proteins involved in glucose utilization in Caco-2 cells
1998 • 22 citations
Effects of Diabetes Mellitus on Hepatocyte Nuclear Factor 1 Decrease Albumin Gene Transcription
1996 • 20 citations
Transcription Factor AP1 Is Involved in Basal and Okadaic Acid-Stimulated Activity of the Human PRL Promoter
1998 • 19 citations
Immunological characterization of hepatocyte nuclear factor 1 protein: appearance of hepatocyte nuclear factor 1 protein in developing mouse embryos.
1993 • 18 citations
Two HNF-1 binding sites govern the glucose repression of the human sucrase-isomaltase promoter
1998 • 16 citations
The J.E. Purkynĕ lecture: the insertion of stalked proteins of the brush border membranes: the state of the art in 1988.
1989 • 14 citations
A set of polyclonal and monoclonal antibodies reveals major differences in post-translational modification of the rat HNF1 and vHNF1 homeoproteins
1997 • 13 citations
Transcription Factor AP1 Is Involved in Basal and Okadaic Acid-Stimulated Activity of the Human PRL Promoter
1998 • 13 citations
Phlorizin or Vanadate Treatment Reverses Impaired Expression of Albumin and Hepatocyte Nuclear Factor 1 in Diabetic Rats
1996 • 11 citations
Okadaic acid induces activator protein 1 activity and immediate early gene transcription in rat pheochromocytoma cells
1994 • 11 citations
Transcriptional Activity in 3T3, F9, and PCC4 Embryonal Carcinoma Cells: A Systematic Deletion and Linker-Scanning Study of the Polyomavirus Enhancer
1994 • 10 citations
Phlorizin or vanadate treatment reverses impaired expression of albumin and hepatocyte nuclear factor 1 in diabetic rats
1996 • 2 citations