Differences in the catalytic efficiencies of allelic variants of glutathione transferase P1-1 towards carcinogenic diol epoxides of polycyclic aromatic hydrocarbons

The Glut athione S-Transferase Supergene Family: Regulation of GST and the Contribution of the lsoenzymes to Cancer Chemoprotection and Drug Resistance Part I

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IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans

1980 • 3,166 citations

[51] Assays for differentiation of glutathione S-Transferases

1981 • 2,259 citations

Preferential Formation of Benzo[ a ]pyrene Adducts at Lung Cancer Mutational Hotspots in P53

1996 • 1,636 citations

Mortality in relation to consumption of alcohol: 13 years' observations on male British doctors

1994 • 1,242 citations

Identification of genetic polymorphisms at the glutathione S- transferase Pi locus and association with susceptibility to bladder, testicular and prostate cancer

1997 • 749 citations

Epoxides in Polycyclic Aromatic Hydrocarbon Metabolism and Carcinogenesis

1974 • 739 citations

Molecular Cloning, Characterization, and Expression in Escherichia coli of Full-length cDNAs of Three Human Glutathione S-Transferase Pi Gene Variants

1997 • 716 citations

Polycyclic aromatic hydrocarbons; chemistry and carcinogenicity

1992 • 542 citations

Naturally Occurring Human Glutathione S‐transferase GSTP1‐1 Isoforms with Isoleucine and Valine in Position 104 Differ in Enzymic Properties

1994 • 451 citations

Genotypes of glutathione transferase M1 and P1 and their significance for lung DNA adduct levels and cancer risk

1997 • 428 citations

Isolation of a cDNA clone and localization of the human glutathione S‐transferase 3 genes to chromosome bands 11q13 and 12q13‐14

1989 • 208 citations

Structural analysis of human alpha-class glutathione transferase A1-1 in the apo-form and in complexes with ethacrynic acid and its glutathione conjugate

1995 • 180 citations

Differences in stereoselectivity and catalytic efficiency of three human glutathione transferases in the conjugation of glutathione with 7 beta,8 alpha-dihydroxy-9 alpha,10 alpha-oxy-7,8,9,10-tetrahydrobenzo(a)pyrene.

1986 • 170 citations

Metabolism of benzo(a)pyrene with isolated hepatocytes and the formation and degradation of DNA-binding derivatives.

1977 • 148 citations

Expression of recombinant glutathione S-transferase pi, Ya, or Yb1 confers resistance to alkylating agents.

1990 • 148 citations

Polycyclic Aromatic Hydrocarbon Carcinogenesis

1985 • 119 citations

Glutathione transferases in rat lung: the presence of transferase 7-7, highly efficient in the conjugation of glutathione with the carcinogenic (+)-7β,8α-dihydroxy-9α,10α-oxy-7,8,9,10-tetrahydrobenzo[a]pyrene

1986 • 118 citations

Primary and secondary structural analyses of glutathione S-transferase π from human placenta

1990 • 107 citations

Glutathione Conjugation of Bay- and Fjord-Region Diol Epoxides of Polycyclic Aromatic Hydrocarbons by Glutathione Transferases M1-1 and P1-1

1997 • 106 citations

Covalent Bonding of Bay-Region Diol Epoxides to Nucleic Acids

1991 • 96 citations

Tumorigenicity in newborn mice of fjord region and other sterically hindered diol epoxides of benzo[g]chrysene, dibenzo[a, l]pyrene (dibenzo[def, p]chrysene), 4H-cyclopenta[def]chrysene and fluoranthene

1995 • 90 citations

CARCINOGENESIS: Glutathione S-transferase A1–1-catalysed conjugation of bay and fjord region diol epoxides of polycyclic aromatic hydrocarbons with glutathione

1996 • 84 citations

Synthesis and mutagenicity of the diastereomeric fjord-region 11,12-dihydrodiol 13,14-epoxides of dibenzo [a,l]pyrene

1994 • 84 citations

Structure and Function of the Xenobiotic Substrate-Binding Site and Location of a Potential Non-Substrate-Binding Site in a Class π Glutathione S-Transferase^,

1997 • 83 citations

GlutathioneS-Transferases of Female A/J Mouse Liver and Forestomach and Their Differential Induction by Anti-carcinogenic Organosulfides from Garlic

1996 • 83 citations

Fjord- and bay-region diol-epoxides investigated for stability, SOS induction in Escherichia coli, and mutagenicity in Salmonella typhimurium and mammalian cells.

1991 • 83 citations

Active Site Architecture of Polymorphic Forms of Human GlutathioneS-Transferase P1-1 Accounts for Their Enantioselectivity and Disparate Activity in the Glutathione Conjugation of 7β,8α-Dihydroxy-9α, 10α-oxy-7,8,9,10-tetrahydrobenzo(a)pyrene

1997 • 82 citations

Tumorigenicity of optical isomers of the diastereomeric bay-region 3,4-diol-1,2-epoxides of benzo(c)phenanthrene in murine tumor models.

1986 • 76 citations

Glutathione conjugation of the carcinogenic and mutagenic electrophile (±)-7β,8α-dihydroxy-9α,10α-oxy-7,8,9,10-tetra hydrobenzo[a]pyrene catalyzed by purified rat liver glutathione transferases

1985 • 68 citations

The enzymatic conjugation of glutathione with bay-region diol-epoxides of benzo[a]pyrene, benz[a]anthracene and chrysene

1986 • 66 citations

Metabolism of benzo(a)pyrene by isolated hepatocytes and factors affecting covalent binding of benzo(a)pyrene metabolites to DNA in hepatocyte and microsomal systems

1980 • 53 citations

High-Level Bacterial Expression of Human Glutathione Transferase P1-1 Encoded by Semisynthetic DNA

1995 • 50 citations

An Alpha Class Mouse Glutathione S-Transferase with Exceptional Catalytic Efficiency in the Conjugation of Glutathione with 7β,8α-Dihydroxy-9α,10α-oxy-7,8,9,10-tetrahydrobenzo(a)pyrene

1996 • 47 citations

Effects of glutathione transferase activity on benzo[a]pyrene 7,8-dihydrodiol metabolism and mutagenesis studied in a mammalian cell co-cultivation assay

1989 • 45 citations

Glutathione conjugation of trans-3,4-dihydroxy 1,2-epoxy l,2,3,4-tetrahydrobenzo[c]phenanthrene isomers by human glutathione transferases

1992 • 25 citations

Modification of glutathione levels in C3H/10T1/2 cells and its relationship to benzo(a)pyrene anti-7,8-dihydrodiol 9,10-epoxide-induced cytotoxicity.

1984 • 22 citations