Hapten-induced colitis associated with maintained Th1 and inflammatory responses in IFN-γ receptor-deficient mice

Interleukin-10-deficient mice develop chronic enterocolitis

1993 • 4,225 citations

CELLULAR RESPONSES TO INTERFERON-γ

1997 • 2,885 citations

Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene

1993 • 1,762 citations

Inhibition of Thl responses prevents inflammatory bowel disease in scid mice reconstituted with CD45RBhi CD4+ T cells

1994 • 1,129 citations

Enterocolitis and colon cancer in interleukin-10-deficient mice are associated with aberrant cytokine production and CD4(+) TH1-like responses.

1996 • 1,128 citations

Phenotypically distinct subsets of CD4⁺ T cells induce or protect from chronic intestinal inflammation in C. B-17 scid mice

1993 • 1,064 citations

IFN-gamma plays a critical down-regulatory role in the induction and effector phase of myelin oligodendrocyte glycoprotein-induced autoimmune encephalomyelitis.

1996 • 642 citations

Murine Macrophages Secrete Interferon γ upon Combined Stimulation with Interleukin (IL)-12 and IL-18: A Novel Pathway of Autocrine Macrophage Activation

1998 • 594 citations

Type 1 T-helper cell predominance and interleukin-12 expression in the gut of patients with Crohn's disease.

1997 • 487 citations

Interferon‐γ confers resistance to experimental allergic encephalomyelitis

1996 • 478 citations

Accelerated collagen-induced arthritis in IFN-gamma receptor-deficient mice.

1997 • 465 citations

Interferon-γ: Biology and Role in Pathogenesis

1996 • 433 citations

Altered Th1/Th2 cytokine profiles in the intestinal mucosa of patients with inflammatory bowel disease as assessed by quantitative reversed transcribed polymerase chain reaction (RT-PCR)

1995 • 400 citations

CD4+ effector cells default to the Th2 pathway in interferon gamma-deficient mice infected with Leishmania major.

1994 • 397 citations

High susceptibility to collagen-induced arthritis in mice lacking IFN-gamma receptors.

1997 • 361 citations

Interleukin-2- and interferon-gamma-secreting T cells in normal and diseased human intestinal mucosa.

1993 • 324 citations

T Cell–mediated Pathology in Two Models of Experimental Colitis Depends Predominantly on the Interleukin 12/Signal Transducer and Activator of Transcription (Stat)-4 Pathway, but Is Not Conditional on Interferon γ Expression by T Cells

1998 • 288 citations

Mice from a genetically resistant background lacking the interferon γ receptor are susceptible to infection with Leishmania major but mount a polarized T helper cell 1-type CD4+ T cell response.

1995 • 242 citations

Induction and prevention of colonic inflammation in IL-2-deficient mice.

1997 • 204 citations

Hapten-induced Colitis Is Associated with Colonic Patch Hypertrophy and T Helper Cell 2–Type Responses

1999 • 177 citations

Acquisition of Selectin Binding and Peripheral Homing Properties by CD4+ and CD8+ T Cells

1999 • 143 citations

Interleukin 18, a Cytokine Which Resembles IL-1 Structurally and IL-12 Functionally but Exerts Its Effect Independently of Both

1998 • 114 citations

Modulation of Cytokine Release and Neutrophil Function by Granulocyte Colony-Stimulating Factor During Endotoxemia in Humans

1997 • 109 citations

Interferon Expression in Crohn's Disease Patients: Increased Interferon-γ and -α mRNA in the Intestinal Lamina Propria Mononuclear Cells

1994 • 63 citations

Involvement of IL-4-producing Vbeta8.2+ CD4+ CD62L- CD45RB- T cells in non-MHC gene-controlled predisposition toward skewing into T helper type-2 immunity in BALB/c mice.

1997 • 58 citations

Expression of L-Selectin on Th1 Cells Is Regulated by IL-12

1999 • 40 citations

Effects of IL‐12 and Antibodies to IL‐12 on Established Granulomatous Colitis in Mice

1996 • 37 citations

CD4+ intestinal mucosal lymphocytes in the pathogenesis of Crohn's disease.

1995 • 13 citations

Deleted Work

1955 • 0 citations