Interferon Expression in Crohn's Disease Patients: Increased Interferon-γ and -α mRNA in the Intestinal Lamina Propria Mononuclear Cells

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Induction by IL 1 and interferon-gamma: tissue distribution, biochemistry, and function of a natural adherence molecule (ICAM-1).

1986 • 2,490 citations

The Molecular Cell Biology of Interferon-gamma and its Receptor

1993 • 1,323 citations

Induction of TH1 and TH2 responses: a key role for the ‘natural’ immune response?

1992 • 794 citations

Interferon alpha increases the frequency of interferon gamma-producing human CD4+ T cells.

1993 • 507 citations

Tumour necrosis factor-alpha and interferon-gamma production measured at the single cell level in normal and inflamed human intestine

1990 • 489 citations

Enhanced production of interleukin 1-beta by mononuclear cells isolated from mucosa with active ulcerative colitis of Crohn's disease.

1989 • 430 citations

Translational Blockade Imposed by Cytokine-Derived UA-Rich Sequences

1989 • 347 citations

Interleukin-2- and interferon-gamma-secreting T cells in normal and diseased human intestinal mucosa.

1993 • 324 citations

Cytokine messenger RNA profiles in inflammatory bowel disease mucosa detected by polymerase chain reaction amplification

1992 • 323 citations

The granulomatous inflammatory response

1990 • 264 citations

Expression of leukocyte adhesion molecules by mucosal mononuclear phagocytes in inflammatory bowel disease

1991 • 197 citations

Molecular cloning of human immune interferon cDNA and its expression in eukaryotic cells

1982 • 192 citations

Activation of peripheral blood and intestinal lamina propria lymphocytes in Crohn's disease. In vivo state of activation and in vitro response to stimulation as defined by the expression of early activation antigens.

1987 • 182 citations

Spontaneous release of interferon gamma by intestinal lamina propria lymphocytes in Crohn's disease. Kinetics of in vitro response to interferon gamma inducers.

1991 • 171 citations

Interleukin 2 Activity of Human Intestinal Mucosa Mononuclear Cells

1984 • 128 citations

Respiratory burst activity of intestinal macrophages in normal and inflammatory bowel disease.

1989 • 125 citations

Immune activation genes in inflammatory bowel disease

1993 • 94 citations

Continuous in vivo activation and transient hyporesponsiveness to TcR/CD3 triggering of human gut lamina propria lymphocytes

1993 • 78 citations

Roles of interferon produced in physiological conditions. A speculative review.

1988 • 77 citations

Interferon ? production by human intestinal mucosal mononuclear cells

1988 • 71 citations

Interleukin 2 receptor expression by macrophages in inflammatory bowel disease.

1988 • 70 citations

HLA-DR antigens on colonic epithelial cells in inflammatory bowel disease: I. Relation to the state of activation of lamina propria lymphocytes and to the epithelial expression of other surface markers.

1987 • 63 citations

Involvement of the Immune System in the Pathogenesis of Crohn's Disease

1985 • 56 citations

Coordinate Induction of Interferon α and γ by Recombinant HIV-1 Glycoprotein 120

1993 • 41 citations

Regulation of IFN-gamma expression in vivo. IFN-gamma up-regulates expression of its mRNA in normal and lipopolysaccharide-stimulated mice.

1993 • 40 citations

Ability of human colonic epithelium to express the 4F2 antigen, the common acute lymphoblastic leukemia antigen, and the transferrin receptor

1989 • 33 citations

Interferon-alpha (IFN-alpha) production by human intestinal mononuclear cells. Response to virus in control subjects and in Crohn's disease.

1992 • 14 citations

Phenotypes and spontaneous immunoglobulin production in mononuclear cells suspensions isolated from colonic biopsies of patients with mild active and quiescent ulcerative colitis.

1991 • 8 citations

Absence of circulating interferon in patients with inflammatory bowel disease. Suggestion against an autoimmune etiology

1992 • 8 citations

Identification of a Functional Allele of a Human Interferon-α Gene Previously Characterized as a Pseudogene

1989 • 3 citations