Activation of lytic Epstein-Barr virus (EBV) infection by radiation and sodium butyrate in vitro and in vivo: a potential method for treating EBV-positive malignancies.

Epstein-Barr Virus

1986 • 2,255 citations

Epstein-Barr virus and its replication

1996 • 1,621 citations

The "bystander effect": tumor regression when a fraction of the tumor mass is genetically modified.

1993 • 1,097 citations

Association of Epstein–Barr Virus with Leiomyosarcomas in Young People with AIDS

1995 • 621 citations

Epstein-Barr virus in nasal T-cell lymphomas in patients with lethal midline granuloma

1990 • 544 citations

Epstein-Barr virus in AIDS-related primary central nervous system lymphoma

1991 • 525 citations

The Association of Epstein–Barr Virus with Smooth-Muscle Tumors Occurring after Organ Transplantation

1995 • 471 citations

Activation of expression of latent Epstein-Barr herpesvirus after gene transfer with a small cloned subfragment of heterogeneous viral DNA.

1985 • 454 citations

Both Epstein-Barr virus (EBV)-encoded trans-acting factors, EB1 and EB2, are required to activate transcription from an EBV early promoter.

1986 • 359 citations

trans activation of the latent Epstein-Barr virus (EBV) genome after transfection of the EBV DNA fragment

1986 • 278 citations

Epstein-Barr viral latency is disrupted by the immediate-early BRLF1 protein through a cell-specific mechanism.

1996 • 222 citations

The spliced BZLF1 gene of Epstein-Barr virus (EBV) transactivates an early EBV promoter and induces the virus productive cycle

1989 • 218 citations

The Epstein-Barr Virus Rta Protein Activates Lytic Cycle Genes and Can Disrupt Latency in B Lymphocytes

1998 • 216 citations

Epstein-Barr virus-latent gene expression and tumor cell phenotype in acquired immunodeficiency syndrome-related non-Hodgkin's lymphoma. Correlation of lymphoma phenotype with three distinct patterns of viral latency.

1993 • 182 citations

Reactive oxygen intermediates target CC(A/T)6GG sequences to mediate activation of the early growth response 1 transcription factor gene by ionizing radiation.

1993 • 172 citations

Prolonged inhibitory effect of 9-(1,3-dihydroxy-2-propoxymethyl)guanine against replication of Epstein-Barr virus

1984 • 159 citations

The Epstein-Barr virus (EBV) BZLF1 immediate-early gene product differentially affects latent versus productive EBV promoters

1989 • 141 citations

The “Bystander Effect”: Association of U-87 Cell Death with Ganciclovir-Mediated Apoptosis of Nearby Cells and Lack of Effect in Athymic Mice

1995 • 137 citations

The choice of prodrugs for gene directed enzyme prodrug therapy of cancer.

1995 • 131 citations

Sodium butyrate enhances fetal globin gene expression in erythroid progenitors of patients with Hb SS and beta thalassemia

1989 • 126 citations

Genome rearrangements activate the Epstein-Barr virus gene whose product disrupts latency.

1988 • 100 citations

Arginine Butyrate-Induced Susceptibility to Ganciclovir in an Epstein–Barr-Virus-Associated Lymphoma

1998 • 96 citations

Effect of Herpes Simplex Virus Thymidine Kinase Expression Levels on Ganciclovir-Mediated Cytotoxicity and the “Bystander Effect”

1995 • 92 citations

Bystander Tumoricidal Effect in the Treatment of Experimental Brain Tumors

1994 • 88 citations

Treatment of AIDS-Related Primary Central Nervous System Lymphoma with Zidovudine, Ganciclovir, and Interleukin 2

1999 • 88 citations

Use of suicide genes in gene therapy

1994 • 87 citations

Induction of lytic Epstein-Barr virus (EBV) infection in EBV-associated malignancies using adenovirus vectors in vitro and in vivo.

1999 • 70 citations

Epstein–Barr virus as a therapeutic target in Hodgkin's disease and nasopharyngeal carcinoma

1996 • 64 citations

Switching viral latency to viral lysis: a novel therapeutic approach for Epstein-Barr virus-associated neoplasia.

1996 • 61 citations

Epstein-Barr Virus Recombinant Lacking Expression of Glycoprotein gp150 Infects B Cells Normally but Is Enhanced for Infection of Epithelial Cells

1998 • 51 citations

Retrovirus-Mediated Herpes Simplex Virus Thymidine Kinase Gene Transduction Renders Human Thyroid Carcinoma Cell Lines Sensitive to Ganciclovir and Radiation in Vitro and in Vivo

1997 • 50 citations

The Zif268 cellular transcription factor activates expression of the Epstein-Barr virus immediate-early BRLF1 promoter

1995 • 47 citations

Reactivation of oral herpes simplex virus

1997 • 45 citations

Preferential radiosensitization of 9L glioma cells transduced with HSV-tk gene by acyclovir.

1997 • 45 citations

Anti-human immunodeficiency virus agent 3'-azido-3'-deoxythymidine inhibits replication of Epstein-Barr virus

1988 • 37 citations

Metabolic activation of 9([2-hydroxy-1-(hydroxymethyl)ethoxy]methyl)guanine in human lymphoblastoid cell lines infected with Epstein-Barr virus

1986 • 34 citations

Characterization of the Epstein-Barr virus-encoded thymidine kinase expressed in heterologous eucaryotic and procaryotic systems

1988 • 34 citations

Killing Epstein-Barr Virus-Positive B Lymphocytes by Gene Therapy: Comparing the Efficacy of Cytosine Deaminase and Herpes Simplex Virus Thymidine Kinase

1996 • 33 citations

Gene Therapy Strategies for Treating Epstein–Barr Virus-Associated Lymphomas: Comparison of Two Different Epstein–Barr Virus-Based Vectors

1998 • 30 citations

Cutaneous herpes simplex virus lesions induced by ultraviolet radiation. A review of model systems and prophylactic therapy with oral acyclovir.

1988 • 26 citations

Selective radiosensitization of 9L glioma in the brain transduced with double suicide fusion gene.

1998 • 26 citations

Tumor retention of 5-fluorouracil following irradiation observed using 19F nuclear magnetic resonance spectroscopy

1996 • 17 citations

Phosphorylation and cytotoxicity of therapeutic nucleoside analogues: a comparison of alpha and gamma herpesvirus thymidine kinase suicide genes.

1998 • 14 citations