Hemorrhage and resuscitation induce alterations in cytokine expression and the development of acute lung injury.

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Oxygen-Derived Free Radicals in Postischemic Tissue Injury

1985 • 5,488 citations

Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1.

1991 • 3,819 citations

Passive Immunization Against Cachectin/Tumor Necrosis Factor Protects Mice from Lethal Effect of Endotoxin

1985 • 2,380 citations

Activation of interleukin-6 gene expression through the NF-kappa B transcription factor.

1990 • 1,377 citations

Homology of Cytokine Synthesis Inhibitory Factor (IL-10) to the Epstein-Barr Virus Gene BCRFI

1990 • 1,155 citations

The inducible transcription activator NF-κB: regulation by distinct protein subunits

1991 • 1,079 citations

Regulation of tumor necrosis factor alpha transcription in macrophages: involvement of four kappa B-like motifs and of constitutive and inducible forms of NF-kappa B.

1990 • 900 citations

Epidemiology of trauma deaths

1980 • 844 citations

Adult Respiratory Distress Syndrome: Risk with Common Predispositions

1983 • 810 citations

Rapid and preferential activation of the c-jun gene during the mammalian UV response.

1991 • 685 citations

Clinical predictors of the adult respiratory distress syndrome

1982 • 684 citations

Biological properties of interleukin 10

1992 • 656 citations

ASSOCIATION OF COMPLEMENT ACTIVATION AND ELEVATED PLASMA-C5a WITH ADULT RESPIRATORY DISTRESS SYNDROME

1980 • 561 citations

High Bronchoalveolar Levels of Tumor Necrosis Factor and Its Inhibitors, Interleukin-1, Interferon, and Elastase, in Patients with Adult Respiratory Distress Syndrome after Trauma, Shock, or Sepsis

1992 • 522 citations

Gut Bacterial Translocation via the Portal Vein

1991 • 494 citations

Multiple Organ Failure in Polytrauma Patients

1983 • 492 citations

AMPLIFICATION OF RNA

1990 • 486 citations

NF-κB and related proteins: Rel/dorsal homologies meet ankyrin-like repeats

1992 • 415 citations

PCR MIMICS: competitive DNA fragments for use as internal standards in quantitative PCR.

1993 • 374 citations

Evidence for IFN-gamma as a mediator of the lethality of endotoxin and tumor necrosis factor-alpha.

1992 • 300 citations

Genomic structure of the murine IL-6 gene. High degree conservation of potential regulatory sequences between mouse and human.

1988 • 297 citations

Effects of accidental trauma on cytokine and endotoxin production

1993 • 270 citations

Hemorrhage Without Tissue Trauma Produces Immunosuppression and Enhances Susceptibility to Sepsis

1987 • 220 citations

TUMOUR NECROSIS FACTOR IN BRONCHOPULMONARY SECRETIONS OF PATIENTS WITH ADULT RESPIRATORY DISTRESS SYNDROME

1989 • 202 citations

Tumor Necrosis Factor Levels in Serum and Bronchoalveolar Lavage Fluid of Patients with the Adult Respiratory Distress Syndrome

1991 • 193 citations

Transcriptional activation of IL-1 beta and tumor necrosis factor-alpha genes by MHC class II ligands.

1991 • 155 citations

Hemorrhage produces abnormalities in lymphocyte function and lymphokine generation.

1989 • 94 citations

Differential Expression of the Tumor Necrosis Factor/Cachectin Gene by Blood and Lung Mononuclear Phagocytes

1988 • 92 citations

Diltiazem restores IL-2, IL-3, IL-6, and IFN-γ synthesis and decreases host susceptibility to sepsis following hemorrhage

1991 • 91 citations

Limited involvement of interleukin‐6 in the pathogenesis of lethal septic shock as revealed by the effect of monoclonal antibodies against interleukin‐6 or its receptor in various murine models

1992 • 83 citations

Intranasal immunization with bacterial polysaccharide containing liposomes enhances antigen-specific pulmonary secretory antibody response

1992 • 83 citations

Studies on the Role of Tumor Necrosis Factor in Adult Respiratory Distress Syndrome

1992 • 82 citations

TEMPORAL PATTERNS OF HEMODYNAMICS, OXYGEN TRANSPORT, CYTOKINE ACTIVITY, AND COMPLEMENT ACTIVITY IN THE DEVELOPMENT OF ADULT RESPIRATORY DISTRESS SYNDROME AFTER SEVERE INJURY

1994 • 78 citations

Effects of hemorrhage on cytokine gene transcription.

1993 • 70 citations

Purification and characterization of intraparenchymal lung lymphocytes.

1990 • 59 citations

Haemorrhage-induced alterations in function and cytokine production of T cells and T cell subpopulations

1992 • 49 citations

Anti-TNF monoclonal antibodies prevent haemorrhage-induced suppression of Kupffer cell antigen presentation and MHC class II antigen expression.

1991 • 46 citations

Effects of hemorrhage and resuscitation on bacterial antigen-specific pulmonary plasma cell function

1991 • 26 citations

Hemorrhage in mice produces alterations in B cell repertoires

1989 • 19 citations

Hemorrhage in mice produces alterations in pulmonary B cell repertoires.

1990 • 17 citations