Microalbuminuria in essential hypertension: Significance, pathophysiology, and therapeutic implications

The Pathogenesis of Atherosclerosis — An Update

1986 • 4,951 citations

Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis

1992 • 4,631 citations

Type 2 (non-insulin-dependent) diabetes mellitus: the thrifty phenotype hypothesis

1992 • 3,255 citations

Insulin Resistance in Essential Hypertension

1987 • 2,386 citations

Diabetes mellitus: a "thrifty" genotype rendered detrimental by "progress"? 1962.

1999 • 2,323 citations

Microalbuminuria Predicts Clinical Proteinuria and Early Mortality in Maturity-Onset Diabetes

1984 • 1,939 citations

MICROALBUMINURIA AS A PREDICTOR OF CLINICAL NEPHROPATHY IN INSULIN-DEPENDENT DIABETES MELLITUS

1982 • 1,683 citations

Predicting Diabetic Nephropathy in Insulin-Dependent Patients

1984 • 1,603 citations

Hyperinsulinemia. A link between hypertension obesity and glucose intolerance.

1985 • 1,485 citations

Long-Term Complications of Diabetes Mellitus

1993 • 1,460 citations

Cholesterol in the Prediction of Atherosclerotic Disease

1979 • 1,333 citations

Quantitation of Muscle Glycogen Synthesis in Normal Subjects and Subjects with Non-Insulin-Dependent Diabetes by¹³C Nuclear Magnetic Resonance Spectroscopy

1990 • 1,226 citations

Circadian blood pressure changes and left ventricular hypertrophy in essential hypertension.

1990 • 1,224 citations

Effect of Insulin and Glucose Infusions on Sympathetic Nervous System Activity in Normal Man

1981 • 1,168 citations

The effect of insulin on renal handling of sodium, potassium, calcium, and phosphate in man.

1975 • 1,114 citations

Cardiovascular risk factors in confirmed prediabetic individuals. Does the clock for coronary heart disease start ticking before the onset of clinical diabetes?

1990 • 1,020 citations

Familial Clustering of Diabetic Kidney Disease

1989 • 991 citations

Advanced Glycosylation End Products in Patients with Diabetic Nephropathy

1991 • 925 citations

Ultrasonographically assessed carotid morphology and the risk of coronary heart disease.

1991 • 924 citations

MICROALBUMINURIA AS PREDICTOR OF VASCULAR DISEASE IN NON-DIABETIC SUBJECTS

1988 • 861 citations

The Progression of Renal Disease

1988 • 840 citations

CORONARY-HEART-DISEASE RISK AND IMPAIRED GLUCOSE TOLERANCE The Whitehall Study

1980 • 800 citations

Long-Term Stabilizing Effect of Angiotensin-Converting Enzyme Inhibition on Plasma Creatinine and on Proteinuria in Normotensive Type II Diabetic Patients

1993 • 795 citations

Risk Factors for Coronary Artery Disease in Healthy Persons with Hyperinsulinemia and Normal Glucose Tolerance

1989 • 792 citations

Relationship of plasma insulin levels to the incidence of myocardial infarction and coronary heart disease mortality in a middle-aged population

1980 • 754 citations

Nitric oxide release accounts for insulin's vascular effects in humans.

1994 • 747 citations

Coronary Heart Disease Incidence and Cardiovascular Mortality in Busselton with Reference to Glucose and Insulin Concentrations

1979 • 746 citations

FACTOR-VIII COMPLEX AND ENDOTHELIAL DAMAGE

1975 • 717 citations

Ultrasonographically assessed carotid morphology and the risk of coronary heart disease.

1991 • 688 citations

International Textbook of Diabetes Mellitus

2003 • 666 citations

Microalbuminuria as predictor of increased mortality in elderly people.

1990 • 631 citations

Cardiovascular Risk Factors in Confirmed Prediabetic Individuals

1990 • 608 citations

Early detection of patients at risk of developing diabetic nephropathy. A longitudinal study of urinary albumin excretion

1982 • 591 citations

Lipoproteins, Cardiovascular Disease, and Death

1981 • 540 citations

Microalbuminuria Predicts Mortality in Noninsulin‐dependent Diabetes

1984 • 531 citations

Relationship Between Level of Blood Pressure Measured Casually and by Portable Recorders and Severity of Complications in Essential Hypertension

1966 • 523 citations

Effect of captopril on progression to clinical proteinuria in patients with insulin-dependent diabetes mellitus and microalbuminuria. European Microalbuminuria Captopril Study Group

1994 • 494 citations

Diurnal blood pressure variations and silent cerebrovascular damage in elderly patients with hypertension.

1992 • 463 citations

Microalbuminuria: A Major Risk Factor in Non‐insulin‐dependent Diabetes. A 10‐year Follow‐up Study of 503 Patients

1988 • 454 citations

Urinary Albumin Excretion

1999 • 449 citations

The Natural History of Impaired Glucose Tolerance in the Pima Indians

1988 • 420 citations

Effect of insulin on the proliferation of cultured primate arterial smooth muscle cells.

1975 • 409 citations

Silent cerebrovascular disease in the elderly. Correlation with ambulatory pressure.

1990 • 391 citations

Microalbuminuria and endothelial dysfunction in essential hypertension

1994 • 387 citations

The prognostic significance of proteinuria: The Framingham study

1984 • 384 citations

Diurnal Variations of Blood Pressure and Microalbuminuria in Essential Hypertension

1994 • 374 citations

Average Daily Blood Pressure, Not Office Blood Pressure, Determines Cardiac Function in Patients With Hypertension

1989 • 364 citations

Microalbuminuria and Peripheral Arterial Disease Are Independent Predictors of Cardiovascular and All-Cause Mortality, Especially Among Hypertensive Subjects

1999 • 364 citations

Efficacy and variability of the antiproteinuric effect of ACE inhibition by lisinopril

1989 • 363 citations

Effect of Captopril on Progression to Clinical Proteinuria in Patients With Insulin-Dependent Diabetes Mellitus and Microalbuminuria

1994 • 353 citations

Salt sensitivity in hypertension. Renal and cardiovascular implications.

1994 • 353 citations

Prognostic significance of microalbuminuria in insulin-dependent diabetes mellitus: A twenty-three year follow-up study

1992 • 334 citations

Microalbuminuria predicts cardiovascular events and renal insufficiency in patients with essential hypertension

1998 • 333 citations

Body fat distribution and hyperinsulinemia as risk factors for diabetes and cardiovascular disease.

1986 • 333 citations

Insulin Resistance, Glucose Intolerance and Hyperinsulinemia in Patients with Hypertension

1989 • 323 citations

Coronary heart disease mortality in relation with diabetes, blood glucose and plasma insulin levels. The Paris Prospective Study, ten years later.

1985 • 318 citations

Combined Renal Effects of Overweight and Hypertension

1995 • 318 citations

Commentary from Westminster

1984 • 309 citations

Screening and management of microalbuminuria in patients with diabetes mellitus: recommendations to the scientific advisory board of the nationals Kidney Foundation from an Ad Hoc Committee of the council on diabetes mel of the national kidney foundation

1995 • 308 citations

Fluid shear stress differentially modulates expression of genes encoding basic fibroblast growth factor and platelet-derived growth factor B chain in vascular endothelium.

1993 • 300 citations

Segmental effects of norepinephrine and angiotensin II on isolated renal microvessels

1983 • 281 citations

Hemodynamic basis for glomerular injury in rats with desoxycorticosterone-salt hypertension.

1984 • 277 citations

Microalbuminuria. Potential marker for increased cardiovascular risk factors in nondiabetic subjects?

1990 • 276 citations

Nephron mass as a risk factor for progression of renal disease.

1997 • 275 citations

Intraglomerular pressure and mesangial stretching stimulate extracellular matrix formation in the rat.

1992 • 270 citations

Role of Lipid Oxidation in Pathogenesis of Insulin Resistance of Obesity and Type II Diabetes

1987 • 265 citations

AN IMMUNOASSAY METHOD FOR URINARY ALBUMIN AT LOW CONCENTRATIONS

1963 • 261 citations

Angiotensin converting enzyme inhibition ameliorates glomerular filtration of macromolecules and water and lessens glomerular injury in the rat.

1990 • 255 citations

Renal Insufficiency in Treated Essential Hypertension

1989 • 254 citations

Radioimmunoassay for Urinary Albumin Using a Single Antibody

1970 • 254 citations

Insulin resistance in insulin-dependent diabetic patients with microalbuminuria

1993 • 249 citations

Effects of long-term physical training on body fat, metabolism, and blood pressure in obesity

1979 • 248 citations

Insulin resistance, hypertension and microalbuminuria in patients with Type 2 (non-insulin-dependent) diabetes mellitus

1993 • 246 citations

Formation of Immunochemical Advanced Glycosylation End Products Precedes and Correlates With Early Manifestations of Renal and Retinal Disease in Diabetes

1995 • 242 citations

WEST INDIAN ONE-YEAR-OLDS

1967 • 242 citations

Hyperinsulinemic Microalbuminuria

1995 • 241 citations

Microalbuminuria in salt-sensitive patients. A marker for renal and cardiovascular risk factors.

1994 • 241 citations

Transcapillary Escape Rate of Albumin and Plasma Volume in Essential Hypertension

1973 • 239 citations

Lipoprotein(a). A genetic risk factor for premature coronary heart disease

1992 • 233 citations

Plasma Insulin Response Among Nauruans: Prediction of Deterioration in Glucose Tolerance Over 6 Yr

1987 • 229 citations

Microalbuminuria Reflects a Generalized Transvascular Albumin Leakiness in Clinically Healthy Subjects

1995 • 222 citations

Effects of calcium antagonists on renal hemodynamics

1985 • 215 citations

Increased transcapillary escape rate of albumin in Type 1 (insulin-dependent) diabetic patients with microalbuminuria

1986 • 214 citations

Prevalence and Clinical Correlates of Microalbuminuria in Essential Hypertension

1997 • 212 citations

Lipids and the kidney

1994 • 211 citations

Evidence of abnormalities of insulin metabolism in rats with spontaneous hypertension

1988 • 209 citations

Altered insulin sensitivity, hyperinsulinemia, and dyslipidemia in individuals with a hypertensive parent

1991 • 209 citations

Effects of Converting-Enzyme Inhibition on Barrier Function in Diabetic Glomerulopathy

1990 • 206 citations

Selectivity of renal injury and proteinuria in the spontaneously hypertensive rat

1977 • 204 citations

Quantitation of Proteinuria by the Use of Protein-to-Creatinine Ratios in Single Urine Samples

1987 • 203 citations

Microalbuminuria in Diabetes Mellitus: Review and Recommendations for the Measurement of Albumin in Urine

1990 • 202 citations

Skeletal muscle blood flow independently modulates insulin-mediated glucose uptake

1994 • 200 citations

Microalbuminuria screening by reagent strip predicts cardiovascular risk in hypertension

1996 • 199 citations

Major Factors in the Development of Diabetes Mellitus in 10,000 Men

1975 • 197 citations

Abnormal renal hemodynamics in black salt-sensitive patients with hypertension.

1991 • 195 citations

Effect of Insulin on Acetylcholine-Induced Vasodilation in Normotensive Subjects and Patients With Essential Hypertension

1995 • 193 citations

Para-amino-salicylic acid in pulmonary tuberculosis.

1949 • 187 citations

Effect of Intra-arterial Insulin on Tissue Cholesterol and Fatty Acids in Alloxan-Diabetic Dogs

1961 • 184 citations

Red-Cell Lithium-Sodium Countertransport and Renal Lithium Clearance in Hypertension

1986 • 184 citations

Microalbuminuria Precedes the Development of NIDDM

1994 • 184 citations

Ambulatory Blood Pressure in the Transition from Normo- to Microalbuminuria: A Longitudinal Study in IDDM Patients

1994 • 174 citations

Hormonal modulation of glomerular function

1983 • 172 citations

Microalbuminuria and Casual and Ambulatory Blood Pressure Monitoring in Normotensives and in Patients With Borderline and Mild Essential Hypertension

1989 • 172 citations

Prevalence of Microalbuminuria in a Large Population of Patients with Mild to Moderate Essential Hypertension

1992 • 169 citations

CARDIOVASCULAR DISEASE RISK FACTORS PRIOR TO THE DIAGNOSIS OF IMPAIRED GLUCOSE TOLERANCE AND NON-INSULIN-DEPENDENT DIABETES MELLITUS IN A COMMUNITY OF OLDER ADULTS

1990 • 158 citations

LDL stimulates mesangial fibronectin production and chemoattractant expression

1993 • 157 citations

Microalbuminuria and associated cardiovascular risk factors in the community

1992 • 157 citations

Glycosaminoglycans prevent morphological renal alterations and albuminuria in diabetic rats

1992 • 157 citations

The Kidney and Hypertension in Diabetes Mellitus

1997 • 151 citations

Microalbuminuria in 411 untreated individuals with established hypertension, white coat hypertension, and normotension.

1994 • 150 citations

Insulin resistance and blood pressure in young black men.

1990 • 147 citations

Ambulatory blood pressure and microalbuminuria in essential hypertension: role of circadian variability.

1994 • 144 citations

Angiotensin converting enzyme inhibition improves glomerular size-selectivity in IgA nephropathy

1991 • 143 citations

Screening for Microalbuminuria: Which Measurement?

1991 • 135 citations

Increased glomerular permeability to albumin induced by exercise in diabetic subjects

1978 • 135 citations

Abnormal renal sodium handling in essential hypertension

1986 • 133 citations

Single-nephron pressures, flows, and resistances in hypertensive kidneys with nephrosclerosis

1977 • 131 citations

Prevalence of microalbuminuria in children with Type 1 (insulin-dependent) diabetes mellitus

1986 • 131 citations

Microalbuminuria, renal dysfunction and cardiovascular complication in essential hypertension

1996 • 130 citations

Induction of glomerulosclerosis by dietary lipids. A functional and morphologic study in the rat.

1989 • 130 citations

Hyperlipidemia and progressive renal disease.

1991 • 129 citations

Serum Lp(a) lipoprotein concentrations in insulin dependent diabetic patients with microalbuminuria.

1991 • 126 citations

Increased thickness of the carotid artery in patients with essential hypertension and microalbuminuria.

1995 • 125 citations

Body Composition and Glucose Metabolism in Hypertensive Middle‐aged Males

1976 • 122 citations

Albumin excretion rate, albumin concentration, and albumin/creatinine ratio compared for screening diabetics for slight albuminuria.

1988 • 122 citations

Comparison of the renal effects of angiotensin converting enzyme inhibitor and calcium antagonist in hypertensive Type 2 (non-insulin-dependent) diabetic patients with microalbuminuria: a randomised controlled trial

1989 • 120 citations

Increased Plasma Apolipoprotein(a) Levels in IDDM Patients With Microalbuminuria

1991 • 119 citations

RACIAL FACTORS IN THE INCIDENCE AND CAUSATION OF END-STAGE RENAL DISEASE (ESRD)

1977 • 119 citations

Renal Hemodynamics and the Renin–Angiotensin–Aldosterone System in Normotensive Subjects with Hypertensive and Normotensive Parents

1991 • 117 citations

Lp(a) lipoprotein concentration in serum of patients with heavy proteinuria of different origin.

1989 • 116 citations

Lipoprotein(a)

1992 • 115 citations

Insulin resistance is associated with high sodium-lithium countertransport in essential hypertension

1991 • 115 citations

Ambulatory Blood Pressure Monitoring and Echocardiographic Left Ventricular Wall Thickness and Mass

1990 • 113 citations

Intrarenal Pressure and Exaggerated Natriuresis in Essential Hypertension

1970 • 112 citations

Screening for Early Diabetic Nephropathy: Which Sample to Detect Microalbuminuria?

1985 • 112 citations

Ambulatory blood pressure and microalbuminuria in essential hypertension

1994 • 112 citations

Microalbuminuria: associations with height and sex in non-diabetic subjects.

1993 • 111 citations

Therapeutic implications of hypertension-induced glomerular injury: Comparison of enalapril and a combination of hydralazine, reserpine, and hydrochlorothiazide in an experimental model

1985 • 111 citations

Apparent Prevalence of Curable Hypertension in the Hypertension Detection and Follow-up Program

1985 • 110 citations

Effect of Antihypertensive Treatment on Urinary Albumin Excretion, Glomerular Filtration Rate, and Renal Plasma Flow in Patients with Essential Hypertension

1976 • 109 citations

The Placenta as a Glucocorticoid Target Tissue: Exchange Assay of (³H)-Dexamethasone Binding and Effect of Steroids on Receptor Content

1983 • 108 citations

Assessment of immunochemical methods for determining low concentrations of albumin in urine.

1986 • 107 citations

The Predictive Value of Microalbuminuriq in IPPM: A five-year follow-up study

1994 • 106 citations

Ambulatory monitoring of blood pressure as a predictor of cardiovascular risk

1987 • 105 citations

Regulation of Glomerular Capillary Pressure and Filtration Rate in Young Kyoto Hypertensive Rats

1979 • 105 citations

Immunoturbidimetry of albumin and immunoglobulin G in urine.

1982 • 105 citations

Comparison of Overnight, Morning and 24‐Hour Urine Collections in the Assessment of Diabetic Microalbuminuria

1987 • 104 citations

LDL enhances monocyte adhesion to endothelial cells in vitro.

1986 • 103 citations

Renal Vasculature in Essential Hypertension: Racial Differences

1978 • 103 citations

Impaired myogenic responsiveness of renal microvessels in Dahl salt-sensitive rats.

1992 • 102 citations

Renal and Systemic Transvascular Albumin Leakage in Severe Atherosclerosis

1995 • 102 citations

Glomerular disease in hypercholesterolemia guinea pigs: A pathogenetic study

1988 • 99 citations

Blood pressure and renal function: therapeutic implications

1996 • 97 citations

Prevalence and Risk Factors for Micro- and Macroalbuminuria in Diabetic Subjects and Entire Population of Nauru

1989 • 97 citations

Elevated serum insulin levels in patients with essential hypertension and microalbuminuria.

1994 • 95 citations

Factors Related to the Presence of Microalbuminuria in Essential Hypertension

1994 • 95 citations

Microalbuminuria in essential hypertension. Reduction by different antihypertensive drugs.

1993 • 94 citations

Impaired insulin sensitivity in young, lean normotensive offspring of essential hypertensives: possible role of disturbed calcium metabolism

1993 • 94 citations

Increased Transcapillary Escape Rate of Albumin in Microalbuminuric Type II Diabetic Patients

1995 • 92 citations

Screening for microalbuminuria in patients with diabetes mellitus: frozen storage of urine samples decreases their albumin content.

1989 • 92 citations

Clustering of cardiovascular risk factors in salt-sensitive patients with essential hypertension: Role of insulin

1996 • 91 citations

Effect of low-dose heparin on urinary albumin excretion in insulin-dependent diabetes mellitus

1995 • 91 citations

The Variability of Overnight Urinary Albumin Excretion in Insulin‐Dependent Diabetic and Normal Subjects

1987 • 91 citations

Insulin resistance and vasodilation in essential hypertension. Studies with adenosine.

1994 • 91 citations

Insulin Resistance in Microalbuminuric Hypertension

1995 • 90 citations

Parental history of diabetes is associated with increased cardiovascular risk factors.

1989 • 89 citations

Hyperinsulinemia in normotensive offspring of hypertensive parents.

1994 • 88 citations

Urinary albumin excretion in healthy adult subjects: Reference values and some factors affecting their interpretation

1988 • 87 citations

Role of hypertension in progressive glomerular immune injury.

1985 • 86 citations

Von Willebrand Factor and Development of Diabetic Nephropathy in IDDM

1991 • 86 citations

Urinary albumin excretion and blood pressure in the general population

1989 • 85 citations

Is microalbuminuria a marker of early intrarenal vascular dysfunction in essential hypertension?

1994 • 83 citations

Insulin resistance is related to albuminuria in patients with type II (non-insulin-dependent) diabetes mellitus

1993 • 82 citations

Effect of Antihypertensive Treatment on Urinary Albumin Excretion, Glomerular Filtration Rate, and Renal Plasma Flow in Patients with Essential Hypertension

1976 • 81 citations

More on effects of storage time and temperature on measurement of small concentrations of albumin in urine.

1991 • 81 citations

Prevalence and Clinical Correlates of Microalbuminuria in Stage I Hypertension Results From the Hypertension and Ambulatory Recording Venetia Study (HARVEST Study)

1996 • 80 citations

Correlation of Office and Ambulatory Blood Pressure Measurements with Urinary Albumin and N-Acetyl- D-Glucosaminidase Excretions in Essential Hypertension

1988 • 80 citations

Cardiovascular and Renal Effects of Long-term Antihypertensive Treatment

1988 • 79 citations

Enzyme immunoassay for urinary albumin.

1983 • 79 citations

Lipoprotein(a) and Asymptomatic Carotid Artery Disease

1995 • 79 citations

Greater renal vascular involvement in the black patient with essential hypertension. A comparison of systemic and renal hemodynamics in black and white patients.

1984 • 78 citations

Nondipping of Nocturnal Blood Pressure Is Related to Urinary Albumin Excretion Rate in Patients With Type 2 Diabetes Mellitus

1996 • 78 citations

The Survival of Treated Hypertensive Patients and their Causes of Death: A Report from the DHSS Hypertensive Care Computing Project (DHCCP)

1986 • 77 citations

Glycosylation is essential for efficient secretion but not for permeability-enhancing activity of vascular permeability factor (vascular endothelial growth factor)

1991 • 77 citations

Microalbuminuria in a Middle-Aged Workforce: Effect of hyperglycemia and ethnicity

1993 • 75 citations

First morning urinary albumin concentration is a good predictor of 24-hour urinary albumin excretion in children with Type I (insulin-dependent) diabetes

1986 • 75 citations

Gender and the Clinical Usefulness of the Albumin:Creatinine Ratio

1994 • 74 citations

Control of glomerular hypertension by insulin administration in diabetic rats.

1989 • 74 citations

Renal Factors Influencing Blood Pressure Threshold and Choice of Treatment for Hypertension in IDDM

1991 • 73 citations

Albuminuria in people at least 40 years old: effect of alcohol consumption, regular exercise, and cigarette smoking

1993 • 73 citations

Effects of ACE inhibition in normotensive patients with chronic glomerular disease and normal renal function

1990 • 72 citations

Enzyme immunoassay for urinary albumin.

1983 • 72 citations

Atherosclerotic risk factors are increased in clinically healthy subjects with microalbuminuria

1995 • 71 citations

Simple immunoturbidimetric method for determining urinary albumin at low concentrations using Cobas-Bio centrifugal analyser.

1987 • 70 citations

Microalbuminuria in treated hypertensive men at high risk of coronary disease

1993 • 69 citations

Evidence of changes in renal charge selectivity in patients with Type 1 (insulin-dependent) diabetes mellitus

1986 • 68 citations

Impaired renal functional reserve and albuminuria in essential hypertension

1988 • 68 citations

Association between salt sensitivity and insulin concentrations in patients with hypertension*

1995 • 68 citations

Microalbuminuria in patients with essential hypertension: Effects of several antihypertensive drugs

1992 • 68 citations

Insulin Sensitivity, Vascular Reactivity, and Clamp-Induced Vasodilatation in Essential Hypertension

1997 • 68 citations

Multicenter Evaluation of the Micral-Test II Test Strip, an Immunologic Rapid Test for the Detection of Microalbuminuria

1997 • 67 citations

Micro-albuminuria as a predictor of cardiovascular damage in essential hypertension

1989 • 67 citations

Differences in urinary albumin excretion rate between normotensive and hypertensive, white and nonwhite subjects.

1992 • 66 citations

Effect of low-dose enalapril on glomerular size-selectivity in human diabetic nephropathy

1993 • 66 citations

Effects of storage time and temperature on measurement of small concentrations of albumin in urine

1990 • 66 citations

Downregulation of High-Density Lipoprotein Receptor in Human Fibroblasts by Insulin and IGF-I

1989 • 66 citations

Normal variations in rate of albumin excretion and albumin to creatinine ratios in overnight and daytime urine collections in non-diabetic children.

1985 • 65 citations

Effects of angiotensin II receptor blockade on remnant glomerular permselectivity

1993 • 64 citations

Increased Transcapillary Escape Rate of Albumin in Nondiabetic Men in Response to Hyperinsulinemia

1990 • 64 citations

Renal functional reserve and microalbuminuria in offspring of hypertensive parents.

1990 • 63 citations

Recognition of Hypertension and Abnormal Blood Pressure Burden With Ambulatory Blood Pressure Recordings in Type I Diabetes Mellitus

1990 • 63 citations

Acute effects of insulin on plasma noradrenaline and the cardiovascular system

1980 • 62 citations

Role of hypertension in progressive glomerular immune injury.

1985 • 62 citations

Sodium-lithium countertransport and cardiorenal abnormalities in essential hypertension.

1991 • 61 citations

Hyperlipidemia of the nephrotic syndrome.

1991 • 61 citations

Growth-Promoting Effects of Diabetes and Insulin on Arteries: An In Vivo Study of Rat Aorta

1986 • 61 citations

Microalbuminuria in Young Adults Related to Blood Pressure in a Biracial (Black-White) Population

1994 • 60 citations

The acute effect of insulin on heart rate, blood pressure, plasma noradrenaline and urinary albumin excretion

1980 • 60 citations

Effect of Insulin on Systemic and Renal Handling of Albumin in Nondiabetic and NIDDM Subjects

1997 • 60 citations

Prognostic value of urinary albumin excretion rate and other risk factors in elderly diabetic patients and non-diabetic control subjects surviving the first 5 years after assessment

1993 • 59 citations

Increased transcapillary escape rate of albumin and IgG in essential hypertension

1977 • 57 citations

Antihypertensive treatment inhibiting the progression of diabetic nephropathy.

1980 • 56 citations

Storage temperature and differing methods of sample preparation in the measurement of urinary albumin

1993 • 56 citations

Close relationship between microalbuminuria and insulin resistance in essential hypertension and non-insulin dependent diabetes mellitus.

1992 • 56 citations

Microalbuminuria is a marker of left ventricular hypertrophy but not hyperinsulinemia in nondiabetic atherosclerotic patients.

1993 • 56 citations

Interactions of hypercholesterolemia and hypertension in initiation of glomerular injury

1992 • 55 citations

Lipoprotein profiles in adult nephrotics.

1975 • 55 citations

Microalbuminuria and body fat distribution in obese subjects.

1994 • 54 citations

Systemic hypertension and the kidney in black patients

1987 • 54 citations

Effect of Angiotensin-Converting Enzyme Inhibition on Renal Function and Albuminuria in Normotensive Type I Diabetic Patients

1992 • 53 citations

Stimulatory Effect of Insulin on Aortic Smooth Muscle Cell Migration Induced by 12-L-Hydroxy-5,8,10,14-Eicosatetraenoic Acid and Its Modulation by Elevated Extracellular Glucose Levels

1985 • 52 citations

Association between hyperlipidemia and microalbuminuria in essential hypertension

1999 • 51 citations

INSULIN STIMULATION OF CHOLESTEROL SYNTHESIS BY ARTERIAL TISSUE

1969 • 51 citations

Antihypertensive Effect of Insulin Reduction in Diabetic-Hypertensive Patients

1989 • 51 citations

Low-density lipoprotein stimulates the expression of macrophage colony-stimulating factor in glomerular mesangial cells

1995 • 49 citations

Dual effect of insulin on plasma volume and transcapillary albumin transport

1992 • 48 citations

Microalbuminuria and cardiovascular risk

1998 • 48 citations

Microalbuminuria and other cardiovascular risk factors in nondiabetic subjects

1992 • 48 citations

Micral-Test Strips Evaluated for Screening for Albuminuria

1992 • 47 citations

Rapidly Reversible Albumin and ??2-microglobulin Hyperexcretion in Recent Severe Essential Hypertension

1983 • 46 citations

Microalbuminuria in Patients With Essential Hypertension

1991 • 46 citations

Glucose tolerance in spontaneously hypertensive rats.

1978 • 45 citations

Comparison of the effects of angiotensin-converting enzyme inhibition and angiotensin II receptor blockade on the evolution of spontaneous glomerular injury in male MWF/Ztm rats.

1996 • 44 citations

Differentiation between vascular permeability factor and IL-2 in lymphocyte supernatants from patients with minimal-change nephrotic syndrome

1991 • 43 citations

Does Microalbuminuria Predict Cardiovascular Events in Nondiabetic Men With Treated Hypertension?

1995 • 41 citations

Predictors for hypertensive nephropathy

1995 • 41 citations

Glomerular hemodynamics in moderate Goldblatt hypertension in the rat.

1982 • 40 citations

Differences in Urinary Albumin Excretion Rate Between Normotensive and Hypertensive, White and Nonwhite Subjects

1992 • 40 citations

Value of Ambulatory Blood Pressure Monitoring in Type I (Insulin-Dependent) Diabetic Patients With Incipient Diabetic Nephropathy

1994 • 39 citations

Albuminuria and 24-h Ambulatory Blood Pressure in Normoalbuminuric and Microalbuminuric NIDDM Patients. A longitudinal study

1995 • 38 citations

Is the aggressive management of hyperlipidemia in nephrotic syndrome mandatory?

1992 • 38 citations

Non-diabetic microalbuminuria in clinical practice and its relationship to posture, exercise and blood pressure

1991 • 38 citations

Reduced glomerular size‐ and charge‐selectivity in clinically healthy individuals with microalbuminuria

1995 • 38 citations

Albumin determination in frozen urines —underestimated results

1988 • 38 citations

Lone-Term Effects of a Converting Enzyme Inhibitor and a Calcium Channel Blocker on Urinary Albumin Excretion in Patients With Essential Hypertension

1993 • 38 citations

Increased serum concentration of von Willebrand factor in non-insulin dependent diabetic patients with and without diabetic nephropathy

1995 • 37 citations

Hypertension, Hyperlipidemia, and Renal Damage

1993 • 37 citations

Lack of correlation between microalbuminuria and endothelial function in essential hypertensive patients

1995 • 37 citations

Biologic Variation of Urinary Albumin: Consequences for Analysis, Specimen Collection, Interpretation of Results, and Screening Programs

1989 • 36 citations

Collecting Urine for Microalbumin Assay

1988 • 36 citations

Micro-albuminuria is correlated with left ventricular hypertrophy in male hypertensive patients

1991 • 36 citations

Decreases in Albumin/Creatinine and N-Acetylglucosaminidase/Creatinine Ratios in Urine Samples Stored At -20 Degrees C

1992 • 36 citations

Effect of Catecholamines and Insulin on Plasma Volume and Intravascular Mass of Albumin in Man

1989 • 33 citations

Small doses of ramipril to reduce microalbuminuria in diabetic patients with incipient nephropathy independently of blood pressure changes.

1991 • 32 citations

Evidence for post-transcriptional regulation by insulin of 3-hydroxy-3-methylglutaryl coenzyme A reductase and sterol synthesis in human mononuclear leucocytes

1984 • 32 citations

Screening Tests for Microalbuminuria in Non-Diabetic Elderly Subjects and Their Relation to Blood Pressure

1995 • 32 citations

Transcapillary escape rate of albumin in hypertensive patients with Type 1 (insulin-dependent) diabetes mellitus

1993 • 30 citations

Relationship of Proteinuria and Albuminuria to Posture and to Urine Collection Period

1983 • 30 citations

Effects of Long-term Antihypertensive Treatment and Aging on Renal Function and Albumin Excretion in Primary Hypertension

1993 • 29 citations

Long-term reduction of microalbuminuria after 3 years of angiotensin-converting enzyme inhibition by perindopril in hypertensive insulin-treated diabetic patients

1992 • 29 citations

Albumin excretion rate and its relation to kidney disease in non‐insulin‐dependent diabetes mellitus

1995 • 29 citations

Activation of Smooth Muscle Cell Outgrowth From BB/Wor Rat Aortas

1988 • 27 citations

Orthopedics: A History and Iconography

1994 • 27 citations

Inhibition of Vascular Permeability Factor Production by Ciclosporin in Minimal Change Nephrotic Syndrome

1992 • 27 citations

Response of urinary albumin to submaximal exercise in newly diagnosed non-insulin dependent diabetes.

1984 • 27 citations

Albuminuria in Association With Insulin and Sodium-Lithium Countertransport in Young African Americans With Borderline Hypertension

1995 • 26 citations

Urinary Albumin Excretion and Nocturnal Blood Pressure in Hypertensive Patients With Type II Diabetes Mellitus

1994 • 26 citations

Microalbuminuria in Obesity

1992 • 26 citations

Dietary nutrient intakes and slight albuminuria in people at least 40 years old

1993 • 25 citations

Epidemiology of microalbuminuria in the general population

1994 • 24 citations

Regulation of endothelin-1 gene expression by cell shape and the microfilament network in vascular endothelium

1997 • 24 citations

Long-term captopril therapy at low doses reduces albumin excretion in patients with essential hypertension and no sign of renal impairment.

1985 • 23 citations

Quinapril reduces microalbuminuria in essential hypertensive and in diabetic hypertensive subjects*

1995 • 23 citations

12 Microalbuminuria in elderly hypertensives: variability and relation to clinic and ambulatory blood pressure

1992 • 23 citations

Small Doses of Ramipril to Reduce Microalbuminuria in Diabetic Patients with Incipient Nephropathy Independently of Blood Pressure Changes

1991 • 21 citations

Angiotensin-Converting Enzyme Inhibition Ameliorates the Defect in Glomerular Size Selectivity in Hyponatremic Hypertensive Syndrome

1989 • 20 citations

Calcium antagonism in essential hypertension: effect on renal haemodynamics and microalbuminuria

1992 • 19 citations

Albumin Excretion Rate and Metabolic Modifications in Patients With Essential Hypertension

1994 • 19 citations

Renal Hemodynamics in Human Subjects and in Animals with Genetic Hypertension during the Prehypertensive Stage

1983 • 19 citations

Impact of Antihypertensive Therapy With Isradipine and Metoprolol on Early Markers of Hypertensive Nephropathy

1992 • 19 citations

Microalbuminuria and cardiovascular risk: a word of caution

1998 • 19 citations

Identifying Patients With Incipient Diabetic Nephropathy

1990 • 18 citations

Meeting Report of the International Society of Hypertension Conference on Hypertension and Diabetes

1992 • 17 citations

Growth factor release by smooth muscle cells is dependent on haemodynamic factors

1992 • 16 citations

Oral glucose increases urinary albumin excretion in normal subjects but not in insulin-dependent diabetics

1980 • 15 citations

Renal effects of pinacidil in hypertensive patients on chronic beta-blocker therapy

1986 • 15 citations

Glucose Metabolism in Spontaneously Hypertensive Rats

1978 • 15 citations

Renal reserve in patients with high blood pressure.

1995 • 15 citations

Microalbuminuria: An Appraisal of Assay Techniques and Urine Collection Procedures for Measuring Urinary Albumin at Low Concentrations

1988 • 14 citations

Diseases of the Alimentary Canal

1844 • 13 citations

Hypertension and microalbuminuria as predictors of diabetic nephropathy.

1989 • 13 citations

Effects of calcium antagonists on glomerular hemodynamics and structure in experimental hypertension.

1991 • 12 citations

Hemodynamic Effects on Glomerular Permselectivity

1990 • 12 citations

Danish general practitioners' estimation of urinary albumin concentration in the detection of proteinuria and microalbuminuria.

1995 • 11 citations

Randomly allocated study of the effects of standard therapy versus ACE inhibition on micro-albuminuria in essential hypertension

1994 • 11 citations

Short‐ and Long‐Term Effects of Spirapril on Renal Hemodynamics in Patients with Essential Hypertension

1993 • 10 citations

Evidence of Impaired Glomerular Charge Selectivity in Nondiabetic Subjects With Microalbuminuria

1996 • 10 citations

Microalbuminuria in elderly hypertensives

1994 • 9 citations

Correlates of abnormal urinary albumin excretion rates among primary care patients with essential hypertension.

1997 • 8 citations

Effects of calcium antagonists on glomerular hemodynamics and structure in experimental hypertension.

1991 • 5 citations

Effect of Beta-Blockade on Albumin Excretion Rate in Essential Hypertension

1990 • 5 citations

Renal effects of nifedipine and captopril in patients with essential hypertension and reduced renal reserve.

1994 • 5 citations

Renal hemodynamics in hypertension.

1987 • 5 citations

Elevated Albumin Excretion in Nonmodulating Essential Hypertensive Patients

1997 • 4 citations