Unbound rather than total concentration and saturation rather than unsaturation determine the potency of fatty acids on insulin secretion

Malonyl-CoA and long chain acyl-CoA esters as metabolic coupling factors in nutrient-induced insulin secretion.

1992 • 440 citations

A 48-hour Lipid Infusion in the Rat Time-Dependently Inhibits Glucose-Induced Insulin Secretion and B Cell Oxidation Through a Process Likely Coupled to Fatty Acid Oxidation*

1990 • 377 citations

Essentiality of circulating fatty acids for glucose-stimulated insulin secretion in the fasted rat.

1996 • 373 citations

Interactions of long-chain fatty acids and albumin: Determination of free fatty acid levels using the fluorescent probe ADIFAB

1993 • 362 citations

The insulinotropic potency of fatty acids is influenced profoundly by their chain length and degree of saturation.

1997 • 350 citations

Unbound free fatty acid levels in human serum.

1995 • 310 citations

Analysis of long-chain free fatty acid binding to bovine serum albumin by determination of stepwise equilibrium constants

1971 • 271 citations

Effects of a 48-h Fat Infusion on Insulin Secretion and Glucose Utilization

1995 • 258 citations

D-Glucose inhibits potassium efflux from pancreatic islet cells

1978 • 208 citations

Mechanisms of the Stimulation of Insulin Release by Saturated Fatty Acids: A Study of Palmitate Effects in Mouse β-cells

1994 • 204 citations

Stimulation of Insulin Secretion by Long-Chain Free Fatty Acids. A DIRECT PANCREATIC EFFECT

1973 • 163 citations

Stimulation of insulin secretion by noncarbohydrate metabolites.

1968 • 160 citations

Physiologic Effects of Metabolic Fuels on Carbohydrate Metabolism: I. Acute Effect of Elevation of Plasma Free Fatty Acids on Hepatic Glucose Output, Peripheral Glucose Utilization, Serum Insulin, and Plasma Glucagon Levels

1967 • 158 citations

Effect of fatty acids on insulin release: role of chain length and degree of unsaturation

1994 • 92 citations

Transcapillary escape rate of albumin in humans during exercise-induced hypervolemia

1997 • 80 citations

Effects of Alterations of Plasma Free Fatty Acid Levels on Pancreatic Glucagon Secretion in Man

1974 • 78 citations

Effects of a 48-h fat infusion on insulin secretion and glucose utilization

1995 • 77 citations

Effect of Acute Elevation of Plasma Glycerol, Triglyceride and FFA Levels on Glucose Utilization and Plasma Insulin

1968 • 73 citations

Glucose stimulation of insulin secretion in islets of fed and starved rats and its dependence on lipid metabolism

1986 • 72 citations

Action of B-Hydroxy Butyrate, Acetoacetate and Palmitate on the Insulin Release in the Perfused Isolated Rat Pancreas

1974 • 71 citations

Differential effects of saturated and monounsaturated fat on blood glucose and insulin responses in subjects with non-insulin-dependent diabetes mellitus

1996 • 71 citations

Starvation-induced changes of palmitate metabolism and insulin secretion in isolated rat islets stimulated by glucose

1984 • 63 citations

Hole of plasma free fatty acids in the control of insulin secretion in man

1973 • 63 citations

Differential effect of unsaturated oils and butter on blood glucose and insulin response to carbohydrate in normal volunteers.

1992 • 50 citations

Polyunsaturated fatty acids augment insulin secretion.

1987 • 49 citations

How the degree of unsaturation of dietary fatty acids influences the glucose and insulin responses to different carbohydrates in mixed meals

1997 • 47 citations

Mechanisms of the stimulation of insulin release by saturated fatty acids. A study of palmitate effects in mouse beta-cells

1994 • 46 citations

Relative contribution of Ca²⁺-dependent and Ca²⁺-independent mechanisms to the regulation of insulin secretion by glucose

1998 • 36 citations

Sampling interstitial fluid from rat skeletal muscles by intermuscular wicks

1991 • 34 citations

Secretory, Biosynthetic, Respiratory, Cationic, and Metabolic Responses of Pancreatic Islets to Palmitate and Oleate

1994 • 25 citations

Effect of oleic and octanoic acids on glucose-induced insulin release in vitro.

1979 • 9 citations

Effect of Lipids on Insulin, Growth Hormone and Exocrine Pancreatic Secretion in Man *

1975 • 2 citations