An avirulent lipophosphoglycan-deficient Leishmania major clone induces CD4+ T cells which protect susceptible BALB/c mice against infection with virulent L. major

Reciprocal expression of interferon gamma or interleukin 4 during the resolution or progression of murine leishmaniasis. Evidence for expansion of distinct helper T cell subsets.

1989 • 1,462 citations

Characterization of the murine T cell surface molecule, designated L3T4, identified by monoclonal antibody GK1.5: similarity of L3T4 to the human Leu-3/T4 molecule.

1983 • 1,307 citations

Immunoregulation of cutaneous leishmaniasis. T cell lines that transfer protective immunity or exacerbation belong to different T helper subsets and respond to distinct parasite antigens.

1988 • 713 citations

Cure of murine leishmaniasis with anti-interleukin 4 monoclonal antibody. Evidence for a T cell-dependent, interferon gamma-independent mechanism.

1990 • 629 citations

A limiting dilution assay for quantifying Leishmania major in tissues of infected mice

1985 • 508 citations

Identification of an Infective Stage of Leishmania Promastigotes

1984 • 498 citations

THE LIPOPHOSPHOGLYCAN OF LEISHMANIA PARASITES

1992 • 473 citations

Leishmania major amastigotes initiate the L-arginine-dependent killing mechanism in IFN-gamma-stimulated macrophages by induction of tumor necrosis factor-alpha.

1990 • 453 citations

Tumor necrosis factor plays a protective role in experimental murine cutaneous leishmaniasis.

1989 • 256 citations

Inhibition of murine T cell‐mediated cytolysis and T cell proliferation by a rat monoclonal antibody immunoprecipitating two lymphoid cell surface polypeptides of 94000 and 180000 molecular weight

1982 • 237 citations

Developmental changes in the glycosylated phosphatidylinositols of Leishmania donovani. Characterization of the promastigote and amastigote glycolipids

1991 • 235 citations

IL-4 inhibits H2O2 production and antileishmanial capacity of human cultured monocytes mediated by IFN-gamma.

1989 • 228 citations

Structure of the lipid moiety of the Leishmania donovani lipophosphoglycan.

1987 • 228 citations

Therapeutic effect of anti-L3T4 monoclonal antibody GK1.5 on cutaneous leishmaniasis in genetically-susceptible BALB/c mice.

1985 • 225 citations

Metacyclogenesis in Leishmania promastigotes

1989 • 215 citations

Diffuse cutaneous leishmaniasis: A disease due to an immunological defect of the host

1972 • 199 citations

Functional heterogeneity of CD4+ T cells in leishmaniasis

1989 • 171 citations

Serum resistance of metacyclic stage Leishmania major promastigotes is due to release of C5b-9.

1990 • 164 citations

Immunological regulation of experimental cutaneous leishmaniasis. III. Nature and significance of specific suppression of cell-mediated immunity in mice highly susceptible to Leishmania tropica.

1980 • 159 citations

Isolation and characterization of infective and non-infective clones of Leishmania tropica

1983 • 151 citations

Requirement of lipophosphoglycan for intracellular survival of Leishmania donovani within human monocytes.

1990 • 144 citations

Exacerbation of murine cutaneous leishmaniasis by adoptive transfer of parasite-specific helper T cell populations capable of mediating Leishmania major-specific delayed-type hypersensitivity.

1984 • 140 citations

Reconstitution of Leishmania immunity in severe combined immunodeficient mice using Th1- and Th2-like cell lines.

1991 • 139 citations

Macrophage activation by interferon‐γ from host‐protective T cells is inhibited by interleukin (IL) 3 and IL 4 produced by disease‐promoting T cells in leishmaniasis

1989 • 130 citations

Structure of the Phosphosaccharide-inositol Core of the Leishmania donovani Lipophosphoglycan

1989 • 127 citations

Passive transfer of Leishmania lipopolysaccharide confers parasite survival in macrophages.

1986 • 127 citations

Tumour necrosis factor (TNF-alpha) in leishmaniasis. II. TNF-alpha-induced macrophage leishmanicidal activity is mediated by nitric oxide from L-arginine.

1990 • 121 citations

Developmental modification of the lipophosphoglycan from Leishmania major promastigotes during metacyclogenesis

1990 • 120 citations

Elimination of CD4+ suppressor T cells from susceptible BALB/c mice releases CD8+ T lymphocytes to mediate protective immunity against Leishmania.

1989 • 114 citations

Establishment of resistance to Leishmania major infection in susceptible BALB/c mice requires parasite-specific CD8⁺ T cells

1991 • 112 citations

Involvement of specific Lyt‐2⁺ T cells in the immunological control of experimentally induced murine cutaneous leishmaniasis

1987 • 108 citations

Protection against Leishmania major in BALB/c mice by adoptive transfer of a T cell clone recognizing a low molecular weight antigen released by promastigotes.

1990 • 91 citations

The involvement of TNF, IL-1 and IL-6 in the immune response to protozoan parasites

1991 • 88 citations

A ricin agglutinin-resistant clone of Leishmania donovani deficient in lipophosphoglycan

1988 • 86 citations

Patterns of cytokine secretion in murine leishmaniasis: correlation with disease progression or resolution

1990 • 86 citations

Immunological regulation and control of experimental leishmaniasis.

1986 • 76 citations

A role for Lyt-2+ T cells in resistance to cutaneous leishmaniasis in immunized mice.

1989 • 74 citations

Role of tumor necrosis factor in macrophage leishmanicidal activity in vitro and resistance to cutaneous leishmaniasis in vivo

1991 • 70 citations

Resistance to murine cutaneous leishmaniasis is mediated by T_H1 cells, but disease‐promoting CD4⁺ cells are different from T_H2 cells

1990 • 69 citations

The induction of protective immunity to Leishmania major in the BALB/c mouse by interleukin 4 treatment

1989 • 65 citations

Antileishmanial defense in macrophages triggered by tumor necrosis factor expressed on CD4+ T lymphocyte plasma membrane.

1991 • 60 citations

Exacerbation of experimental murine cutaneous leishmaniasis with CD4⁺Leishmania major‐specific T cell lines or clones which secrete interferon‐γ and mediate parasite‐specific delayed‐type hypersensitivity

1991 • 57 citations

Immunity to experimental infection with Leishmania major: generation of protective L3T4⁺ T cell clones recognizing antigen(s) associated with live parasites

1989 • 56 citations

Characterization of Leishmania donovani variant clones using anti-lipophosphoglycan monoclonal antibodies

1990 • 38 citations

Cytokine control of Leishmania infection in the BALB/c mouse: enhancement and inhibition of parasite growth by local administration of IL‐2 or IL‐4 is species and time dependent

1992 • 37 citations

Variants with reduced virulence derived from Leishmania major after mutagen treatment

1987 • 34 citations

Reversion to virulence in Leishmania major correlates with expression of surface lipophosphoglycan

1993 • 16 citations

Th2 lymphocyte clone can activate macrophage antileishmanial defense by a lymphokine-independent mechanism in vitro and can augment parasite attrition in vivo

1991 • 14 citations

Leishmania major: Nature of immunity induced by immunization with a mutagenized avirulent clone of the parasite in mice

1990 • 14 citations

Causal Association of Interferon-γ with Tumor Regression

1989 • 13 citations

Role of T Cells in Immunity to the Intracellular Pathogen, Leishmania major

1992 • 7 citations

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