Intracerebral administration of interleukin-1β and induction of inflammation, apoptosis, and vasogenic edema

Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation.

1992 • 9,540 citations

Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death

1993 • 6,009 citations

Apoptosis and necrosis: two distinct events induced, respectively, by mild and intense insults with N-methyl-D-aspartate or nitric oxide/superoxide in cortical cell cultures.

1995 • 1,968 citations

Glutamate-induced neuronal death: A succession of necrosis or apoptosis depending on mitochondrial function

1995 • 1,892 citations

The Heterogeneity of Mononuclear Phagocytes in Lymphoid Organs: Distinct Macrophage Subpopulations in Rat Recognized by Monoclonal Antibodies ED1, ED2 and ED3

1985 • 1,605 citations

Tumor necrosis factor mediates myelin and oligodendrocyte damage in vitro

1988 • 1,371 citations

BCL2 protein is topographically restricted in tissues characterized by apoptotic cell death.

1991 • 1,301 citations

Bright and dark sides of nitric oxide in ischemic brain injury

1997 • 1,043 citations

Altered neuronal and microglial responses to excitotoxic and ischemic brain injury in mice lacking TNF receptors

1996 • 947 citations

Cytokines and the nervous system II: actions and mechanisms of action

1995 • 928 citations

Delayed neuronal death in the CA1 pyramidal cell layer of the gerbil hippocampus following transient ischemia is apoptosis

1995 • 834 citations

Tumor necrosis factor-alpha expression in ischemic neurons.

1994 • 793 citations

Analysis of cell surfaces by xenogeneic myeloma-hybrid antibodies: Differentiation antigens of rat lymphocytes

1977 • 777 citations

Cytokines and the nervous system I: expression and recognition

1995 • 745 citations

The influence of cytokines on the integrity of the blood-brain barrier in vitro

1996 • 641 citations

Toward an understanding of the molecular mechanisms of physiological cell death.

1993 • 623 citations

Interleukin-1 injected into mammalian brain stimulates astrogliosis and neovascularization

1988 • 587 citations

Detection of interleukin-1 and interleukin-6 in adult rat brain, following mechanical injury, by in vivo microdialysis: evidence of a role for microglia in cytokine production

1991 • 579 citations

Interleukin-1 as a Pathogenetic Mediator of Ischemic Brain Damage in Rats

1995 • 572 citations

Interleukin-1 receptor antagonist inhibits ischaemic and excitotoxic neuronal damage in the rat

1992 • 547 citations

Increase in IL-6, IL-1 and TNF levels in rat brain following traumatic lesion

1993 • 517 citations

Evidence of apoptotic cell death after experimental traumatic brain injury in the rat.

1995 • 517 citations

The role of mononuclear phagocytes in wound healing after traumatic injury to adult mammalian brain

1989 • 504 citations

Proapoptotic Protein Bax Heterodimerizes with Bcl-2 and Homodimerizes with Bax via a Novel Domain (BH3) Distinct from BH1 and BH2

1996 • 462 citations

Cytokine cytotoxicity against oligodendrocytes. Apoptosis induced by lymphotoxin.

1991 • 455 citations

Upregulation of bax protein levels in neurons following cerebral ischemia

1995 • 440 citations

Macrophages and inflammation in the central nervous system

1993 • 390 citations

Recombinant human interleukin-1 induces meningitis and blood-brain barrier injury in the rat. Characterization and comparison with tumor necrosis factor.

1991 • 375 citations

Different prooxidant levels stimulate growth, trigger apoptosis, or produce necrosis of insulin-secreting RINm5F cells. The role of intracellular polyamines.

1994 • 372 citations

Monoclonal antibody to a triggering structure expressed on rat natural killer cells and adherent lymphokine-activated killer cells.

1989 • 365 citations

Mechanisms of delayed cell death following hypoxic-ischemic injury in the immature rat: evidence for apoptosis during selective neuronal loss

1995 • 356 citations

Interleukin-1 beta mRNA expression in ischemic rat cortex.

1993 • 335 citations

Cerebral Hypoxia-Ischemia Stimulates Cytokine Gene Expression in Perinatal Rats

1995 • 282 citations

Intracerebral inflammatory response to experimental brain contusion

1995 • 278 citations

Cytokine-stimulated astrocytes damage human neurons via a nitric oxide mechanism

1996 • 271 citations

Intracerebral Inflammation after Human Brain Contusion

1998 • 270 citations

Cytokines and Metabolic Dysfunction After Severe Head Injury

1994 • 266 citations

Interleukin-1 receptor antagonist inhibits neuronal damage caused by fluid percussion injury in the rat

1995 • 252 citations

Use of specific gravity in the measurement of cerebral edema

1971 • 250 citations

Critical Influences of the Cytokine Orchestration on the Outcome of Myelin Antigen‐Specific T‐Cell Autoimmunity in Experimental Autoimmune Encephalomyelitis and Multiple Sclerosis

1995 • 239 citations

Correlation between Proinflammatory Cytokines and Antiinflammatory Mediators and the Severity of Disease in Meningococcal Infections

1995 • 227 citations

Elevation of tumor necrosis factor in head injury

1990 • 226 citations

Effect of tumor necrosis factor on epithelial tight junctions and transepithelial permeability.

1990 • 224 citations

Experimental brain injury induces expression of interleukin-1β mRNA in the rat brain

1995 • 217 citations

Delayed and Progressive Brain Injury in Closed-Head Trauma

1993 • 209 citations

Reactive mononuclear phagocytes release neurotoxins after ischemic and traumatic injury to the central nervous system

1993 • 193 citations

Recombinant human tumor necrosis factor α constricts pial arterioles and increases blood-brain barrier permeability in newborn piglets

1992 • 192 citations

Delayed cytokine expression in rat brain following experimental contusion

1997 • 189 citations

Interleukin‐1‐like activity in rat brain: Sources, targets, and effects of injury

1987 • 180 citations

Differential susceptibility of human CNS-derived cell populations to TNF-dependent and independent immune-mediated injury

1995 • 180 citations

Ventricular fluid interleukin-1 activity in patients with head injury.

1987 • 164 citations

Evidence of Nuclear DNA Fragmentation Following Hypoxia‐Ischemia in the Infant Rat Brain, and Transient Forebrain Ischemia in the Adult Gerbil

1994 • 150 citations

Expression of transforming growth factor-?1 and interleukin-1? mRNA in rat brain following transient forebrain ischemia

1993 • 150 citations

Ultrastructural studies of the blood-retina barrier after exposure to interleukin-1 beta or tumor necrosis factor-alpha.

1994 • 147 citations

Long-Term Observations of Intracranial Pressure after Severe Head Injury. The Phenomenon of Secondary Rise of Intracranial Pressure

1993 • 116 citations

Apoptosis: a gene-directed programme of cell death.

1992 • 115 citations

Circulating adhesion molecules and inflammatory mediators in demyelination

1995 • 113 citations

The pathological spectrum of diffuse axonal injury in blunt head trauma: assessment with axon and myelin stains

1994 • 92 citations

Immunohistochemical localization of neurofilaments and neuron-specific enolase in 29 cases of neuroblastoma.

1986 • 76 citations

Cytokine Expression in Radiation-induced Delayed Cerebral Injury

1994 • 73 citations

Effect of tumor necrosis factor α and β on human oligodendrocytes and neurons in culture

1995 • 71 citations

Lymphocyte adhesion to cultured Peyer's patch high endothelial venule cells is mediated by organ-specific homing receptors and can be regulated by cytokines.

1990 • 58 citations

Traumatic intracerebral lesions without extracerebral haematoma in 218 patients

1995 • 47 citations

Biphasic edema development after experimental brain contusion in rat

1995 • 44 citations

Dexamethasone and colchicine reduce inflammation and delayed oedema following experimental brain contusion

1996 • 43 citations

Monoclonal antibody production to human and bovine 2′:3′-cyclic nucleotide 3′-phosphodiesterase (CNPase): high-specificity recognition in whole brain acetone powders and conservation of sequence between CNP1 and CNP2

1987 • 41 citations

Immune-Mediated Injury in Bacterial Meningitis

1993 • 29 citations

Tungsten treatment prevents tumor necrosis factor-induced injury of brain endothelial cells

1992 • 22 citations