TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-β

Pathogen Recognition and Innate Immunity

2006 • 11,197 citations

Innate Immune Recognition

2002 • 8,157 citations

Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3

2001 • 5,893 citations

Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses

2006 • 3,607 citations

The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5

2001 • 3,507 citations

Innate Antiviral Responses by Means of TLR7-Mediated Recognition of Single-Stranded RNA

2004 • 3,325 citations

Role of Adaptor TRIF in the MyD88-Independent Toll-Like Receptor Signaling Pathway

2003 • 3,104 citations

The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling

2007 • 2,524 citations

IRF-7 is the master regulator of type-I interferon-dependent immune responses

2005 • 2,108 citations

Dynasore, a Cell-Permeable Inhibitor of Dynamin

2006 • 1,905 citations

Recognition of single-stranded RNA viruses by Toll-like receptor 7

2004 • 1,777 citations

DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response

2007 • 1,609 citations

The dynamin superfamily: universal membrane tubulation and fission molecules?

2004 • 1,329 citations

TLR9 signals after translocating from the ER to CpG DNA in the lysosome

2004 • 1,326 citations

Toll-Like Receptor Signaling Pathways

2003 • 1,236 citations

TICAM-1, an adaptor molecule that participates in Toll-like receptor 3–mediated interferon-β induction

2003 • 1,203 citations

TRAF2-Mediated Activation of NF-κB by TNF Receptor 2 and CD40

1995 • 1,046 citations

TRAM is specifically involved in the Toll-like receptor 4–mediated MyD88-independent signaling pathway

2003 • 1,023 citations

Control of EGF Receptor Signaling by Clathrin-Mediated Endocytosis

1996 • 998 citations

Interferon-α induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6

2004 • 994 citations

Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4

2002 • 985 citations

TIRAP: an adapter molecule in the Toll signaling pathway

2001 • 962 citations

Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6

2005 • 915 citations

Critical role of TRAF3 in the Toll-like receptor-dependent and -independent antiviral response

2005 • 847 citations

IRF3 Mediates a TLR3/TLR4-Specific Antiviral Gene Program

2002 • 844 citations

β-Arrestin 2: A Receptor-Regulated MAPK Scaffold for the Activation of JNK3

2000 • 804 citations

The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors

2002 • 803 citations

TLR4, but not TLR2, mediates IFN-β–induced STAT1α/β-dependent gene expression in macrophages

2002 • 802 citations

Phosphoinositide-Mediated Adaptor Recruitment Controls Toll-like Receptor Signaling

2006 • 797 citations

Intracellular localization of Toll-like receptor 9 prevents recognition of self DNA but facilitates access to viral DNA

2005 • 649 citations

Localized Biphasic Changes in Phosphatidylinositol-4,5-Bisphosphate at Sites of Phagocytosis

2000 • 537 citations

PHOSPHOINOSITIDE LIPIDS AS SIGNALING MOLECULES: Common Themes for Signal Transduction, Cytoskeletal Regulation, and Membrane Trafficking

1998 • 515 citations

ADP-Ribosylation Factor 6 Regulates a Novel Plasma Membrane Recycling Pathway

1997 • 494 citations

Compartmentalization of TNF Receptor 1 Signaling

2004 • 479 citations

Endocytic pathways regulate Toll-like receptor 4 signaling and link innate and adaptive immunity

2006 • 456 citations

Antiviral Signaling Through Pattern Recognition Receptors

2006 • 441 citations

Legionella phagosomes intercept vesicular traffic from endoplasmic reticulum exit sites

2002 • 441 citations

Clathrin-independent pinocytosis is induced in cells overexpressing a temperature-sensitive mutant of dynamin.

1995 • 400 citations

TIR-containing Adapter Molecule (TICAM)-2, a Bridging Adapter Recruiting to Toll-like Receptor 4 TICAM-1 That Induces Interferon-β

2003 • 399 citations

Lipopolysaccharide Interaction with Cell Surface Toll-like Receptor 4-MD-2

2003 • 378 citations

Macropinosome maturation and fusion with tubular lysosomes in macrophages.

1993 • 332 citations

The myristoylation of TRIF-related adaptor molecule is essential for Toll-like receptor 4 signal transduction

2006 • 263 citations

Targeted Disruption of TRAF3 Leads to Postnatal Lethality and Defective T-Dependent Immune Responses

1996 • 239 citations

Recruitment of CD40 and Tumor Necrosis Factor Receptor-associated Factors 2 and 3 to Membrane Microdomains during CD40 Signaling

2000 • 201 citations

A Dimer of the Toll-Like Receptor 4 Cytoplasmic Domain Provides a Specific Scaffold for the Recruitment of Signalling Adaptor Proteins

2007 • 189 citations

A role for clathrin in the sorting of vacuolar proteins in the Golgi complex of yeast.

1992 • 157 citations

Regulation of lipopolysaccharide-inducible genes by MyD88 and Toll/IL-1 domain containing adaptor inducing IFN-β

2005 • 136 citations

The membrane targeting and spatial activation of Src, Yes and Fyn is influenced by palmitoylation and distinct RhoB/RhoD endosome requirements

2007 • 97 citations

MAPPIT analysis of TLR adaptor complexes

2007 • 29 citations

Effects of dynamin inactivation on pathways of anthrax toxin uptake

2004 • 29 citations