Network Analysis in the Investigation of Chronic Respiratory Diseases. From Basics to Application

Cytoscape: A Software Environment for Integrated Models of Biomolecular Interaction Networks

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Bioconductor: open software development for computational biology and bioinformatics.

2004 • 11,755 citations

Network medicine: a network-based approach to human disease

2010 • 4,396 citations

Network motifs: theory and experimental approaches

2007 • 3,170 citations

The human disease network

2007 • 3,104 citations

Biological robustness

2004 • 2,025 citations

Transcription factors: from enhancer binding to developmental control

2012 • 2,021 citations

Causal Protein-Signaling Networks Derived from Multiparameter Single-Cell Data

2005 • 1,664 citations

Interactome Networks and Human Disease

2011 • 1,651 citations

Reverse engineering of regulatory networks in human B cells

2005 • 1,408 citations

Discovering regulatory and signalling circuits in molecular interaction networks

2002 • 1,199 citations

Integrative approaches for finding modular structure in biological networks

2013 • 535 citations

minet: A R/Bioconductor Package for Inferring Large Transcriptional Networks Using Mutual Information

2008 • 523 citations

Interactome-transcriptome analysis reveals the high centrality of genes differentially expressed in lung cancer tissues

2005 • 406 citations

MicroRNA-21 Integrates Pathogenic Signaling to Control Pulmonary Hypertension

2012 • 257 citations

Application of ’omics technologies to biomarker discovery in inflammatory lung diseases

2013 • 255 citations

Abnormal Lung Aging in Chronic Obstructive Pulmonary Disease and Idiopathic Pulmonary Fibrosis

2012 • 247 citations

Systems medicine and integrated care to combat chronic noncommunicable diseases

2011 • 245 citations

BioNet: an R-Package for the functional analysis of biological networks

2010 • 225 citations

DisGeNET: a Cytoscape plugin to visualize, integrate, search and analyze gene–disease networks

2010 • 224 citations

Revolutionizing medicine in the 21^st century through systems approaches

2012 • 222 citations

A network framework of cultural history

2014 • 212 citations

A survey of current software for network analysis in molecular biology

2010 • 185 citations

Addressing the Complexity of Chronic Obstructive Pulmonary Disease

2010 • 183 citations

CyTargetLinker: A Cytoscape App to Integrate Regulatory Interactions in Network Analysis

2013 • 123 citations

RCytoscape: tools for exploratory network analysis

2013 • 104 citations

A protein interaction network associated with asthma

2008 • 99 citations

The use of network analyses for elucidating mechanisms in cardiovascular disease

2009 • 93 citations

Metabolic Network Analysis of Pseudomonas aeruginosa during Chronic Cystic Fibrosis Lung Infection

2010 • 88 citations

Distinct transcriptional regulatory modules underlie STAT3’s cell type-independent and cell type-specific functions

2013 • 76 citations

A Systems Biology Approach Identifies Molecular Networks Defining Skeletal Muscle Abnormalities in Chronic Obstructive Pulmonary Disease

2011 • 74 citations

Network medicine, multimorbidity and the lung in the elderly

2014 • 70 citations

Network medicine analysis of COPD multimorbidities

2014 • 64 citations

A Functional and Regulatory Map of Asthma

2007 • 55 citations

Towards Systems Biology of Human Pulmonary Fibrosis

2007 • 49 citations

A diVIsive Shuffling Approach (VIStA) for gene expression analysis to identify subtypes in Chronic Obstructive Pulmonary Disease

2014 • 49 citations

Systemic Inflammatory Response to Smoking in Chronic Obstructive Pulmonary Disease: Evidence of a Gender Effect

2014 • 47 citations

Beyond the diagnosis of idiopathic pulmonary fibrosis; the growing role of systems biology and stratified medicine

2013 • 29 citations

Systematic identification of transcriptional regulatory modules from protein–protein interaction networks

2013 • 29 citations

Joint Bayesian inference of condition-specific miRNA and transcription factor activities from combined gene and microRNA expression data

2012 • 29 citations

Integrative Systems Biology Approaches in Asthma Pharmacogenomics

2012 • 26 citations

Network analysis identifies a putative role for the PPAR and type 1 interferon pathways in glucocorticoid actions in asthmatics

2012 • 22 citations

Chronic lung diseases

2009 • 22 citations

Modelling treatment effects in a clinical Bayesian network using Boolean threshold functions

2008 • 21 citations

Network analysis of single nucleotide polymorphisms in asthma

2010 • 17 citations

Delineation of a Gene Network Underlying the Pulmonary Response to Oxidative Stress in Asthma

2009 • 15 citations

Cyrface: An interface from Cytoscape to R that provides a user interface to R packages

2013 • 3 citations