Synthesis and in vitro activities of new tryptophan-modified and thiomethylene-containing pseudopeptide antagonists of the neurokinins

A Potent Nonpeptide Antagonist of the Substance P (NK ₁ ) Receptor

1991 • 875 citations

Peptides Chemistry, Structure and Biology

1990 • 510 citations

Pharmacological properties of a potent and selective nonpeptide substance P antagonist.

1991 • 429 citations

PyBOP® and PyBroP: Two reagents for the difficult coupling of the α,α-dialkyl amino acid, Aib.

1991 • 217 citations

A new, highly efficient method for the conversion of alcohols to thiolesters and thiols

1981 • 212 citations

Biological evaluation of substance P antagonists

1984 • 189 citations

Potent and highly selective neurokinin antagonists

1990 • 160 citations

THE PEPTIDES: Analysis, Synthesis, Biology

1979 • 158 citations

Synthesis of (racemization prone) optically active thiols by SN2 substitution using cesium thiocarboxylates

1986 • 124 citations

Modification of tryptophan residues during acidolysis of 4-methoxy-2,3,6-trimethylbenzenesulfonyl groups. Effects of scavengers

1987 • 70 citations

The use of 2,2′-dithiobis-(5-nitropyridine) as a selective reagent for the detection of thiols

1969 • 60 citations

Thiol synthesis

1968 • 49 citations

Preparation and application of new acid labile anchor groups for the synthesis of peptide amides by FMOC solid phase synthesis

1987 • 35 citations

Synthesis of protected amino alcohols: a comparative study

1981 • 35 citations

Synthesis and determination of enantiomeric excesses of non-racemic tert-thiols derived from chiral secondary α-mercaptocarboxylic acids

1987 • 31 citations

Enkephalin pseudopeptides: Resistance to in vitro proteolytic degradation afforded by amide bond replacements extends to remote sites

1985 • 30 citations

Amide bond surrogates: pseudopeptides and macrocycles

1988 • 27 citations

Reduced Peptide Bond Pseudopeptide Analogues of Substance P

1989 • 24 citations

Backbone modifications in cyclic pep tides Conformational analysis of a cyclic pseudopentapeptide containing a thiomethylene ether amide bond replacement

1990 • 20 citations

Design and Therapeutic Potential of Peptides

1991 • 19 citations

Neurokinin receptors antagonists: Old and new

1991 • 19 citations

The Synthesis of DL-Threonine.^* I. From α-Bromo-β-methoxy-n-butyric Acid and Derivatives

1949 • 17 citations

Synthesis and conformational studies of Zabicipril (S 9650-3), a potent inhibitor of angiotensin converting enzyme

1992 • 16 citations

Antagonists of substance P. Further modifications of SP antagonists obtained by replacing either positions 7, 9 or 7, 8 and 11 of SP with D-amino acid residues

1986 • 10 citations