Functional characterization of human immunodeficiency virus type 1 nef genes in patients with divergent rates of disease progression

Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection

1995 • 4,310 citations

The CD4 (T4) antigen is an essential component of the receptor for the AIDS retrovirus

1984 • 3,530 citations

Viral dynamics in human immunodeficiency virus type 1 infection

1995 • 3,277 citations

Complete nucleotide sequence of the AIDS virus, HTLV-III

1985 • 2,236 citations

The T4 gene encodes the AIDS virus receptor and is expressed in the immune system and the brain

1986 • 2,020 citations

HIV Population Dynamics in Vivo: Implications for Genetic Variation, Pathogenesis, and Therapy

1995 • 1,997 citations

Importance of the nef gene for maintenance of high virus loads and for development of AIDS

1991 • 1,613 citations

Virologic and Immunologic Characterization of Long-Term Survivors of Human Immunodeficiency Virus Type 1 Infection

1995 • 1,044 citations

Absence of Intact nef Sequences in a Long-Term Survivor with Nonprogressive HIV-1 Infection

1995 • 1,008 citations

Studies in Subjects with Long-Term Nonprogressive Human Immunodeficiency Virus Infection

1995 • 750 citations

Nef induces CD4 endocytosis: Requirement for a critical dileucine motif in the membrane-proximal CD4 cytoplasmic domain

1994 • 701 citations

The isolation and nucleotide sequence of a cDNA encoding the T cell surface protein T4: a new member of the immunoglobulin gene family

1985 • 669 citations

Proline-rich (PxxP) motifs in HIV-1 Nef bind to SH3 domains of a subset of Src kinases and are required for the enhanced growth of Nef+ viruses but not for down-regulation of CD4.

1995 • 557 citations

Human immunodeficiency virus type 1 Vpu protein induces rapid degradation of CD4

1992 • 553 citations

The human immunodeficiency virus-1 nef gene product: a positive factor for viral infection and replication in primary lymphocytes and macrophages.

1994 • 536 citations

Optimal infectivity in vitro of human immunodeficiency virus type 1 requires an intact nef gene

1994 • 372 citations

HIV-1 nef leads to inhibition or activation of T cells depending on its intracellular localization

1994 • 305 citations

Downregulation of cell-surface CD4 expression by simian immunodeficiency virus Nef prevents viral super infection.

1993 • 291 citations

Altered T cell activation and development in transgenic mice expressing the HIV-1 nef gene.

1993 • 282 citations

Long-term symptomless HIV-1 infection in recipients of blood products from a single donor

1992 • 239 citations

The characterization of non-progressors: long-term HIV-1 infection with stable CD4+ T-cell levels.

1993 • 238 citations

Characterization of nef sequences in long-term survivors of human immunodeficiency virus type 1 infection

1995 • 191 citations

The human immunodeficiency virus type 1 Vpu protein specifically binds to the cytoplasmic domain of CD4: implications for the mechanism of degradation

1995 • 188 citations

CD4 down-regulation by nef alleles isolated from human immunodeficiency virus type 1-infected individuals.

1993 • 186 citations

Human immunodeficiency virus type 1 Nef-induced down-modulation of CD4 is due to rapid internalization and degradation of surface CD4

1994 • 179 citations

Long-Term Human Immunodeficiency Virus Infection in Asymptomatic Homosexual and Bisexual Men with Normal CD4+ Lymphocyte Counts: Immunologic and Virologic Characteristics

1991 • 160 citations

Predictors of rapid progression to AIDS in HIV-1 seroconverters

1993 • 155 citations

Expression of the human immunodeficiency virus type 1 (HIV-1) nef gene during HIV-1 production increases progeny particle infectivity independently of gp160 or viral entry

1995 • 140 citations

Human immunodeficiency virus type 1 Vpu protein induces degradation of CD4 in vitro: the cytoplasmic domain of CD4 contributes to Vpu sensitivity

1993 • 134 citations

Human immunodeficiency virus type 1 mRNA expression in peripheral blood cells predicts disease progression independently of the numbers of CD4+ lymphocytes.

1994 • 130 citations

Human immunodeficiency virus type 1 Nef protein inhibits activation pathways in peripheral blood mononuclear cells and T-cell lines

1995 • 128 citations

Nef from primary isolates of human immunodeficiency virus type 1 suppresses surface CD4 expression in human and mouse T cells

1993 • 118 citations

Defective accessory genes in a human immunodeficiency virus type 1-infected long-term survivor lacking recoverable virus

1995 • 113 citations

Clinical, immunologic, and serologic findings in men at risk for acquired immunodeficiency syndrome. The San Francisco Men's Health Study.

1987 • 102 citations

Human immunodeficiency virus type 1 Nef and p56lck protein-tyrosine kinase interact with a common element in CD4 cytoplasmic tail.

1995 • 100 citations

The initial immune response to HIV and immune system activation determine the outcome of HIV disease.

1991 • 97 citations

Vpu-induced degradation of CD4: requirement for specific amino acid residues in the cytoplasmic domain of CD4

1993 • 91 citations

Negative-strand RNA transcripts are produced in human immunodeficiency virus type 1-infected cells and patients by a novel promoter downregulated by Tat

1994 • 91 citations

Characteristics of Long-Term Asymptomatic Infection with Human Immunodeficiency Virus Type 1 in Men with Normal and Low CD4+ Cell Counts

1994 • 89 citations

The cytoplasmic domain of CD4 is sufficient for its down-regulation from the cell surface by human immunodeficiency virus type 1 Nef

1994 • 89 citations

CD4 cell surface downregulation in HIV-1 Nef transgenic mice is a consequence of intracellular sequestration.

1993 • 87 citations

Changes in the viral mRNA expression pattern correlate with a rapid rate of CD4+ T-cell number decline in human immunodeficiency virus type 1-infected individuals

1995 • 86 citations

Human immunodeficiency virus type 1 Vpu protein induces degradation of chimeric envelope glycoproteins bearing the cytoplasmic and anchor domains of CD4: role of the cytoplasmic domain in Vpu-induced degradation in the endoplasmic reticulum

1993 • 81 citations

Human immunodeficiency virus type 1 Nef induces accumulation of CD4 in early endosomes

1995 • 80 citations

Human immunodeficiency virus type 1 cellular RNA load and splicing patterns predict disease progression in a longitudinally studied cohort

1995 • 76 citations

Absence of Recoverable Infectious Virus and Unique Immune Responses in an Asymptomatic HIV⁺Long-Term Survivor

1994 • 75 citations

Naturally occurring genotypes of the human immunodeficiency virus type 1 long terminal repeat display a wide range of basal and Tat-induced transcriptional activities

1994 • 71 citations

Normal Immune Function and Inability to Isolate Virus in Culture in an Individual with Long-Term Human Immunodeficiency Virus Type 1 Infection*

1994 • 65 citations

Nef 27, but Not the Nef 25 Isoform of Human Immunodeficiency Virus-Type 1 pNL4.3 Down-Regulates Surface CD4 and IL-2R Expression in Peripheral Blood Mononuclear Cells and Transformed T Cells

1994 • 62 citations

Antibody Responses to HIV-1 Envelope and GAG Epitopes in HIV-1 Seroconverters with Rapid versus Slow Disease Progression

1994 • 58 citations

Sequences present in the cytoplasmic domain of CD4 are necessary and sufficient to confer sensitivity to the human immunodeficiency virus type 1 Vpu protein

1994 • 50 citations

Mutational analysis of the human immunodeficiency virus type 1 Eli Nef function.

1992 • 49 citations

Specific Suppression of Human CD4 Surface Expression by Nef from the Pathogenic Simian Immunodeficiency Virus SIVmac239open

1994 • 37 citations

Regulation of Human Immunodeficiency Virus Nef Protein by Phosphorylation

1994 • 30 citations

Humans with OKT4-epitope deficiency have a single nucleotide base change in the CD4 gene, resulting in substitution of TRP240 for ARG240

1991 • 28 citations

Extensive allelic polymorphism in the CDR2-like region of the miniature swine CD4 molecule.

1993 • 22 citations

Characterization of a polymorphism of CD4 in miniature swine.

1992 • 19 citations

Down-regulation of CD4 molecules by the expression of Nef: a quantitative analysis of CD4 antigens on the cell surfaces

1993 • 18 citations

The generation of monoclonal antibodies recognising novel epitopes by immunisation with solid matrix antigen-antibody complexes reveals a polymorphic determinant on feline CD4

1994 • 14 citations

Possible association of CD3 and CD4 polymorphisms with insulin-dependent diabetes mellitus (IDDM)

1994 • 13 citations