Quantification and sequencing of somatic deleted mtDNA in single cells: evidence for partially duplicated mtDNA in aged human tissues

Replication of animal mitochondrial DNA

1982 • 1,221 citations

Detection of a specific mitochondrial DNA deletion in tissues of older humans

1990 • 784 citations

An autosomal dominant disorder with multiple deletions of mitochondrial DNA starting at the D-loop region

1989 • 637 citations

Maternally transmitted diabetes and deafness associated with a 10.4 kb mitochondrial DNA deletion

1992 • 612 citations

Introduction of disease-related mitochondrial DNA deletions into HeLa cells lacking mitochondrial DNA results in mitochondrial dysfunction.

1991 • 548 citations

Mosaicism for a specific somatic mitochondrial DNA mutation in adult human brain

1992 • 416 citations

Coupled Leading- and Lagging-Strand Synthesis of Mammalian Mitochondrial DNA

2000 • 415 citations

Mitochondrial DNA deletion mutations colocalize with segmental electron transport system abnormalities, muscle fiber atrophy, fiber splitting, and oxidative damage in sarcopenia

2001 • 368 citations

Role of mitochondrial DNA mutations in human aging: Implications for the central nervous system and muscle

1998 • 285 citations

A proposed refinement of the mitochondrial free radical theory of aging

1997 • 271 citations

Mitochondria in organismal aging and degeneration

1999 • 178 citations

Cell-by-cell scanning of whole mitochondrial genomes in aged human heart reveals a significant fraction of myocytes with clonally expanded deletions

1999 • 176 citations

Different in situ hybridization patterns of mitochondrial DNA in cytochrome c oxidase-deficient extraocular muscle fibres in the elderly

1993 • 171 citations

Mutations in mitochondrial DNA accumulate differentially in three different human tissues during ageing

1998 • 167 citations

Families of mtDNA re-arrangements can be detected in patients with mtDNA deletions: duplications may be a transient intermediate form

1993 • 162 citations

Maternally inherited duplication of the mitochondrial genome in a syndrome of proximal tubulopathy, diabetes mellitus, and cerebellar ataxia.

1992 • 157 citations

Rearrangements of Human Mitochondrial DNA (mtDNA): New Insights into the Regulation of mtDNA Copy Number and Gene Expression

2000 • 131 citations

Multi-Organ Characterization of Mitochondrial Genomic Rearrangements in Ad Libitum and Caloric Restricted Mice Show Striking Somatic Mitochondrial DNA Rearrangements with Age

1997 • 113 citations

A Tridecamer DNA Sequence Supports Human Mitochondrial RNA 3′-End Formation In Vitro

1988 • 101 citations

Behaviour of a population of partially duplicated mitochondrial DNA molecules in cell culture: segregation, maintenance and recombination dependent upon nuclear background

1997 • 101 citations

Maternally transmitted partial direct tandem duplication of mitochondrial DNA associated with diabetes mellitus

1993 • 100 citations

The Reductive Hotspot Hypothesis: An Update

2000 • 98 citations

Maintenance of Human Rearranged Mitochondrial DNAs in Long-Term Cultured Transmitochondrial Cell Lines

2000 • 91 citations

The rate of mitochondrial mutagenesis is faster in mice than humans

1997 • 85 citations

Are duplications of mitochondrial DNA characteristic of Kearns—Sayre syndrome?

1994 • 77 citations

Cellular phenotypes of age-associated skeletal muscle mitochondrial abnormalities in rhesus monkeys

2000 • 74 citations

A tandem duplication in the D–loop of human mitochondrial DNA is associated with deletions in mitochondrial myopathies

1993 • 73 citations

Cytochrome c oxidase defects of the human substantia nigra in normal aging

1996 • 72 citations

Association of myopathy with large‐scale mitochondrial dna duplications and deletions: Which is pathogenic?

1997 • 71 citations

Age-Related Extensive Fragmentation of Mitochondrial DNA into Minicircles

1996 • 64 citations

The complete and symmetric transcription of the main non coding region of rat mitochondrial genome: in vivo mapping of heavy and light transcripts

1990 • 54 citations

Tandem direct duplications of mitochondrial DNA in mitochondrial myopathy: analysis of nucleotide sequence and tissue distribution

1989 • 53 citations

Accumulation of Deletions in MtDNA During Tissue Aging: Analysis by Long PCR

1995 • 50 citations

Origin, transmission, and segregation of mitochondrial DNA dimers in mouse hybrid and cybrid cell lines

1984 • 19 citations

Duplication and triplication with staggered breakpoints in human mitochondrial DNA

1998 • 14 citations