Importance of free radicals generated by endothelial and myocardial cells in ischemia and reperfusion

Superoxide Dismutase

1969 • 12,578 citations

Hydroperoxide metabolism in mammalian organs.

1979 • 5,821 citations

Oxygen-Derived Free Radicals in Postischemic Tissue Injury

1985 • 5,488 citations

The thrombolysis in myocardial infarction (TIMI) trial. Phase I findings

1985 • 3,610 citations

The Biology of Oxygen Radicals

1978 • 3,361 citations

Biology of disease: free radicals and tissue injury.

1982 • 3,078 citations

The Thrombolysis in Myocardial Infarction (TIMI) Trial

1985 • 3,078 citations

Leukotrienes: Mediators of Immediate Hypersensitivity Reactions and Inflammation

1983 • 2,839 citations

The mitochondrial generation of hydrogen peroxide. General properties and effect of hyperbaric oxygen

1973 • 2,608 citations

EFFECTIVENESS OF INTRAVENOUS THROMBOLYTIC TREATMENT IN ACUTE MYOCARDIAL INFARCTION

1986 • 2,315 citations

The wavefront phenomenon of ischemic cell death. 1. Myocardial infarct size vs duration of coronary occlusion in dogs.

1977 • 1,927 citations

Generation of superoxide anion by the NADH dehydrogenase of bovine heart mitochondria

1980 • 1,609 citations

Direct observation of a free radical interaction between vitamin E and vitamin C

1979 • 1,460 citations

Myocardial reperfusion: a double-edged sword?

1985 • 1,355 citations

Superoxide radicals in feline intestinal ischemia

1981 • 1,213 citations

Direct measurement of free radical generation following reperfusion of ischemic myocardium.

1987 • 1,185 citations

Superoxide Radical: An Endogenous Toxicant

1983 • 1,176 citations

THE EFFECT OF CORONARY OCCLUSION ON MYOCARDIAL CONTRACTION

1935 • 1,133 citations

Lipid peroxidation damage to cell components.

1973 • 925 citations

Canine myocardial reperfusion injury. Its reduction by the combined administration of superoxide dismutase and catalase.

1984 • 915 citations

Demonstration of free radical generation in "stunned" myocardium of intact dogs with the use of the spin trap alpha-phenyl N-tert-butyl nitrone.

1988 • 691 citations

Xanthine oxidase as a source of free radical damage in myocardial ischemia

1985 • 678 citations

The free radical pathology and the microcirculation in the major central nervous system disorders.

1980 • 660 citations

Direct detection of free radicals in the reperfused rat heart using electron spin resonance spectroscopy.

1987 • 628 citations

Reperfusion-induced arrhythmias: Mechanisms and prevention

1984 • 574 citations

The oxygen paradox and the calcium paradox: Two facets of the same problem?

1978 • 491 citations

Reperfusion of the ischemic myocardium

1977 • 469 citations

Plasma glutathione and glutathione disulfide in the rat: regulation and response to oxidative stress.

1983 • 463 citations

The regulation of rat liver xanthine oxidase. Involvement of thiol groups in the conversion of the enzyme activity from dehydrogenase (type D) into oxidase (type O) and purification of the enzyme

1972 • 432 citations

Relation between high energy phosphate and lethal injury in myocardial ischemia in the dog.

1978 • 417 citations

Mitochondrial production of superoxide anions and its relationship to the antimycin insensitive respiration

1975 • 403 citations

Species, Tissue and Subcellular Distribution of Non Se-Dependent Glutathione Peroxidase Activity

1978 • 399 citations

FUNCTIONAL and STRUCTURAL ASPECTS OF BIOLOGICAL MEMBRANES: A SUGGESTED STRUCTURAL ROLE FOR VITAMIN E IN THE CONTROL OF MEMBRANE PERMEABILITY and STABILITY

1972 • 388 citations

Oxygen-mediated myocardial damage during ischameia and reperfusion: Role of the cellular defences against oxygen toxicity

1985 • 384 citations

Release of endogenous catecholamines in the ischemic myocardium of the rat. Part A: Locally mediated release.

1984 • 369 citations

The pathophysiology of superoxide: roles in inflammation and ischemia

1982 • 368 citations

Identification of free radicals in myocardial ischemia/reperfusion by spin trapping with nitrone DMPO

1987 • 357 citations

Reduction in experimental infarct size by recombinant human superoxide dismutase: insights into the pathophysiology of reperfusion injury.

1986 • 344 citations

Identification of neutral active phospholipase C which hydrolyzes choline glycerophospholipids and plasmalogen selective phospholipase A2 in canine myocardium.

1985 • 315 citations

The biochemical modes of action of vitamin e and selenium: A hypothesis

1973 • 310 citations

Occurrence of oxidative stress during reperfusion of the human heart.

1990 • 297 citations

Free radicals and myocardial ischemia: Overview and outlook

1988 • 286 citations

INHIBITION OF PHOSPHOLIPASE

1983 • 284 citations

Myocardial Salvage after Intracoronary Thrombolysis with Streptokinase in Acute Myocardial Infarction

1981 • 279 citations

The species distribution of xanthine oxidase

1965 • 267 citations

Ischemia and reperfusion-induced arrhythmias in the rat. Effects of xanthine oxidase inhibition with allopurinol.

1984 • 265 citations

Adriamycin stimulated superoxide formation in submitochondrial particles

1977 • 256 citations

FREE RADICAL BIOLOGY: XENOBIOTICS, CANCER, AND AGING*

1982 • 252 citations

Vibriobactin, a siderophore from Vibrio cholerae.

1984 • 248 citations

Cerebral Arteriolar Damage by Arachidonic Acid and Prostaglandin G ₂

1980 • 245 citations

The oxygen free radical system: A fundamental mechanism in the production of myocardial necrosis

1986 • 236 citations

Potential Oxidative Pathways of Catecholamines in the Formation of Lipid Peroxides and Genesis of Heart Disease

1983 • 226 citations

Thromboxane and prostacyclin release from ischaemic myocardium in relation to arrhythmias

1981 • 220 citations

Response of reperfusion-salvaged, stunned myocardium to inotropic stimulation

1984 • 210 citations

Cardiac transport of glutathione disulfide and S-conjugate. Studies with isolated perfused rat heart during hydroperoxide metabolism.

1984 • 206 citations

Molecular Basis of the Biological Function of Molybdenum

1974 • 205 citations

Xanthine oxidase type D (dehydrogenase) in the intestine and other organs of the rat

1972 • 201 citations

Reduction of the size of infarction by allopurinol in the ischemic-reperfused canine heart.

1986 • 193 citations

Peroxisomes: new aspects of cell physiology and biochemistry.

1977 • 192 citations

Recombinant superoxide dismutase reduces oxygen free radical concentrations in reperfused myocardium.

1987 • 190 citations

Oxygen radicals in the adult respiratory distress syndrome, in myocardial ischemia and reperfusion injury, and in cerebral vascular damage

1985 • 189 citations

Failure of superoxide dismutase and catalase to alter size of infarction in conscious dogs after 3 hours of occlusion followed by reperfusion.

1986 • 189 citations

Responses of the ischemic myocardium to allopurinol

1971 • 183 citations

Failure of the xanthine oxidase inhibitor allopurinol to limit infarct size after ischemia and reperfusion in dogs.

1985 • 180 citations

Characterization of cardiac sarcoplasmic reticulum dysfunction during short-term, normothermic, global ischemia.

1984 • 171 citations

Therapeutic Approaches to Myocardial Infarct Size Limitation

1985 • 161 citations

Superoxide and superoxide dismutase in chemistry, biology and medicine

1987 • 158 citations

Free Radicals and Myocardial Ischemia

1985 • 158 citations

Molecular Basis of the Biological Function of Molybdenum

1974 • 156 citations

Free radicals and myocardial ischemia. The role of xanthine oxidase.

1985 • 153 citations

Myocardial recovery during post-ischaemic reperfusion: Effects of nifedipine, calcium and magnesium

1986 • 146 citations

Superoxide and superoxide dismutase in chemistry, biology and medicine

1987 • 141 citations

In vitro study on contribution of oxidative metabolism of isolated rabbit heart mitochondria to myocardial reperfusion injury.

1984 • 136 citations

Spin trapping of oxygen and carbon-centered free radicals in ischemic canine myocardium

1987 • 126 citations

Potential electrophysiologic mechanisms responsible for dysrhythmias associated with reperfusion of ischemic myocardium.

1983 • 125 citations

Plasma Hypoxanthine Concentrations in Pigs

1980 • 123 citations

Changes in the cardiac glutathione status after ischemia and reperfusion

1985 • 120 citations

Biochemical aspects of physical exercise

1987 • 113 citations

Drug Metabolism Concepts

1977 • 111 citations

Protection of Human Neutrophils by Endogenous Catalase

1980 • 108 citations

Effect of α-tocopherol on hypoxic-perfused and reoxygenated rabbit heart muscle

1978 • 106 citations

Therapeutic Approaches to Myocardial Infarct Size Limitation

1984 • 94 citations

The role of xanthine oxidase during myocardial ischemia in several species including man

1988 • 93 citations

Improved procedure for determining glutathione in plasma as an index of myocardial oxidative stress.

1987 • 89 citations

Free radical mediation of the effects of acidosis on calcium transport by cardiac sarcoplasmic reticulum in whole heart homogenates

1984 • 89 citations

Assessment of myocardial oxidative stress in patients after myocardial revascularization

1988 • 82 citations

Low calcium reperfusion of ischemic myocardium

1983 • 81 citations

The molecular basis for radiation effects on cells.

1966 • 80 citations

Improved procedure for determining glutathione in plasma as an index of myocardial oxidative stress.

1987 • 77 citations

Molecular Basis of the Biological Function of Molybdenum

1974 • 71 citations

Early Arrhythmias Resulting from Myocardial Ischaemia

1982 • 66 citations

The effect of allopurinol on the degree of early myocardial ischemia

1980 • 64 citations

Drug Metabolism Concepts

1977 • 63 citations

Xanthine Oxidase is Not Responsible for Reoxygenation Injury in Isolated-Perfused Rat Heart

1987 • 59 citations

Sites of lipase activation and prostaglandin synthesis in isolated, perfused rabbit hearts and hydronephrotic kidneys

1978 • 57 citations

Arrhythmias and infarction in the ischemic pig heart are not mediated by xanthine oxidase-derived free oxygen radicals

1987 • 57 citations

Biochemical Aspects of Physical Exercise

1986 • 54 citations

Oxygen free radicals and reperfusion injury; the effect of ischaemia and reperfusion on the cellular ability to neutralise oxygen toxicity

1986 • 53 citations

Metabolic changes during post-ischaemic reperfusion

1988 • 53 citations

Intracellular effects of myocardial ischaemia and reperfusion: role of calcium and oxygen.

1986 • 52 citations

Significance of increased blood uric acid following extensive hemorrhage

1968 • 51 citations

Myocardial ischemia—Observations, definitions and speculations

1970 • 48 citations

Analysis of reported randomized trials of streptokinase therapy for acute myocardial infarction in the 1980s

1987 • 48 citations

Effect of allopurinol (Zyloric) on patients undergoing open heart surgery.

1979 • 42 citations

Pathogenetic Mechanism of Post-Infarction Angina

1986 • 42 citations

Failure of allopurinol and a spin trapping agent N‐t‐butyl‐α‐phenyl nitrone to modify significantly ischaemia and reperfusion‐induced arrhythmias

1987 • 37 citations

Beneficial actions of a free radical scavenger in traumatic shock and myocardial ischemia.

1981 • 35 citations

Allopurinol amelioration of the pathophysiology of acute myocardial infarction in rats

1981 • 32 citations

Effect of lipid peroxidation on heart mitochondria oxygen consuming and calcium transporting capacities

1988 • 30 citations

Is superoxide demonstration by electron-spin resonance spectroscopy really superoxide?

1988 • 29 citations

Oxidative stress during myocardial ischaemia and reperfusion: Experimental and clinical evidence

1986 • 28 citations

Introduction to the role of oxygen radicals in myocardial ischemia and infarction

1988 • 27 citations

Vitamin E and the heart: possible role as antioxidant.

1983 • 27 citations

Cytochrome P-450—Its Role in Oxygen Activation for Drug Metabolism

1977 • 26 citations

Myocardial Catecholamine Release in Acute Myocardial Ischaemia; Relationship to Cardiac Arrhythmias

1982 • 25 citations

Alterations of Glutathione Status during Myocardial Ischaemia and Reperfusion

1988 • 23 citations

Evidence for lipid peroxidation during the calcium paradox in vitamin E-deficient rat heart

1984 • 21 citations

Molecular Events Occurring During Post-Ischaemic Reperfusion

1987 • 11 citations

Calcium and lipid peroxidation in mitochondrial and microsomal membranes of the heart

1983 • 11 citations

Importance of early recanalization of the occluded coronary artery in acute myocardial infarction for preservation of left ventricular function

1988 • 11 citations

No evidence of oxygen free radicals-mediated damage during the calcium paradox

1989 • 9 citations

Myocardial metabolism during intracoronary thrombolysis. Two illustrative cases

1987 • 8 citations

Myocardial Mitochondrial Functions in α-Tocopherol-Deficient and -Refed Rabbits

1982 • 7 citations