Hormonal Support of Lacrimal Function, Primary Lacrimal Deficiency, Autoimmunity, and Peripheral Tolerance in the Lacrimal Gland

Effects of Estrogen or Estrogen/ Progestin Regimens on Heart Disease Risk Factors in Postmenopausal Women

1995 • 2,281 citations

Autoantigens targeted in systemic lupus erythematosus are clustered in two populations of surface structures on apoptotic keratinocytes.

1994 • 1,722 citations

Report of the National Eye Institute/Industry workshop on Clinical Trials in Dry Eyes.

1995 • 1,674 citations

Clonal Expansion Versus Functional Clonal Inactivation: A Costimulatory Signalling Pathway Determines the Outcome of T Cell Antigen Receptor Occupancy

1989 • 1,512 citations

Preliminary criteria for the classification of Sjögren's syndrome. Results of a prospective concerted action supported by the European community

1993 • 1,438 citations

ROLE OF ABERRANT HLA-DR EXPRESSION AND ANTIGEN PRESENTATION IN INDUCTION OF ENDOCRINE AUTOIMMUNITY

1983 • 1,275 citations

ABERRANT EXPRESSION OF HLA-DR ANTIGEN ON THYROCYTES IN GRAVES' DISEASE: RELEVANCE FOR AUTOIMMUNITY

1983 • 710 citations

Ia expression by vascular endothelium is inducible by activated T cells and by human gamma interferon.

1983 • 638 citations

Transepithelial Transport of Immunoglobulins

1994 • 457 citations

Sarcoidosis and Its Ophthalmic Manifestations

1978 • 441 citations

Clinical biochemistry of tears

1981 • 427 citations

Molecular Cloning and Characterization of an Aquaporin cDNA from Salivary, Lacrimal, and Respiratory Tissues

1995 • 414 citations

Anergic T Cells as Suppressor Cells in Vitro

1994 • 389 citations

BIRTH CONTROL FOR PROBLEM PARENTS

1964 • 381 citations

Twenty-four-hour mean plasma testosterone concentration declines with age in normal premenopausal women.

1995 • 365 citations

Apoptotic photoreceptor degeneration in experimental retinal detachment.

1995 • 364 citations

The preocular tear film : in health, disease, and contact lens wear

1986 • 327 citations

The endocrinology of the menopausal transition: a cross-sectional study of a population-based sample.

1995 • 319 citations

The Role of Somatic Hypermutation in the Generation of Antibody Diversity

1989 • 305 citations

A Diffuse Infiltrative CD8 Lymphocytosis Syndrome in Human Immunodeficiency Virus (HIV) Infection: A Host Immune Response Associated with HLA-DR5

1990 • 284 citations

Comparison of the effects of estrogen alone and estrogen plus androgen on biochemical markers of bone formation and resorption in postmenopausal women.

1996 • 276 citations

Organ‐Specific Autoimmunity: A 1986 Overview

1986 • 274 citations

Relationship between DNA fragmentation and apoptosis in the programmed cell death in the rat prostate following castration

1989 • 266 citations

Differential symptom response to parenteral estrogen and/or androgen administration in the surgical menopause

1985 • 260 citations

PATHOGENESIS OF SJÖGREN’S SYNDROME

1992 • 235 citations

Association of patterns of labial salivary gland inflammation with keratoconjunctivitis SICCA

1994 • 230 citations

Sjögren-Type Syndrome After Allogeneic Bone-Marrow Transplantation

1977 • 218 citations

Presence of epidermal growth factor in human tears.

1989 • 213 citations

Luminal membrane retrieved after exocytosis reaches most Golgi cisternae in secretory cells

1977 • 204 citations

Ocular Manifestations of Graft-vs-Host Disease

1983 • 201 citations

In exocrine pancreas, the basolateral endocytic pathway converges with the autophagic pathway immediately after the early endosome.

1990 • 196 citations

Sjögren's syndrome: cytokine and Epstein-Barr viral gene expression within the conjunctival epithelium.

1994 • 195 citations

Senile atrophy of the human lacrimal gland: the contribution of chronic inflammatory disease.

1984 • 194 citations

Sex Differences in the Twenty-Four-Hour Mean Plasma Concentrations of Dehydroisoandrosterone (DHA) and Dehydroisoandrosterone Sulfate (DHAS) and the DHA to DHAS Ratio in Normal Adults*

1980 • 189 citations

Mood, Sexuality, Hormones, and the Menstrual Cycle. III. Sexuality and the Role of Androgens

1983 • 167 citations

Distribution of newly synthesized lysosomal enzymes in the endocytic pathway of normal rat kidney cells.

1991 • 164 citations

Hormonal regulation of the expression of la antigens on mammary gland epithelium

1980 • 145 citations

Cyclic ADP-ribose, the ADP-ribosyl cyclase pathway and calcium signalling

1994 • 139 citations

Virus infection induces redistribution and membrane localization of the nuclear antigen La (SS-B): a possible mechanism for autoimmunity.

1989 • 136 citations

CRITERIA FOR DIAGNOSIS OF SJOGREN'S SYNDROME

1994 • 135 citations

Topical cyclosporin treatment of keratoconjunctivitis sicca in secondary Sjögren's syndrome

1994 • 131 citations

The Immunoarchitecture of the Normal Human Lacrimal Gland

1988 • 129 citations

A New Perspective on Canine Keratoconjunctivitis Sicca

1990 • 126 citations

Hepatocyte growth factor and hepatocyte growth factor receptor in the lacrimal gland, tears, and cornea.

1996 • 125 citations

Symptomatology of HEMA Contact Lens Wear

1989 • 122 citations

Requirement for CD8⁺Cells in T Cell Receptor Peptide-Induced Clonal Unresponsiveness

1993 • 122 citations

Primary Sjögren's syndrome in men

1986 • 118 citations

Mononuclear Cell Phenotypes and Immunoglobulin Gene Rearrangements in Lacrimal Gland Biopsies from Patients with Sjögren's Syndrome

1990 • 111 citations

T cells as antigen-presenting cells

1994 • 109 citations

Antigen presentation by human B cells: T cell proliferation induced by Epstein Barr virus B lymphoblastoid cells.

1982 • 103 citations

HLA-DR Antigens on Retinal Pigment Epithelial Cells From Patients With Uveitis

1986 • 101 citations

Active chloride transport in the pigmented rabbit conjunctiva

1993 • 100 citations

Three Different Types of Dry Eye Syndrome

1994 • 94 citations

A prospective long-term study in women from pre-menopause to post-menopause: changing profiles of gonadotrophins, oestrogens and androgens

1986 • 93 citations

Hormonal influence on the secretory immune system of the eye: androgen regulation of secretory component levels in rat tears.

1984 • 89 citations

Secretion of group 2 phospholipase A2 by lacrimal glands.

1994 • 89 citations

Regulation of Tear Secretion

1994 • 88 citations

The Eye in Bone Marrow Transplantation

1983 • 85 citations

The Autoimmune Nature of Aqueous Tear Deficiency

1986 • 85 citations

Endocytic pathways at the lateral and basal cell surfaces of exocrine acinar cells.

1982 • 84 citations

Water and electrolyte secretion by the exorbital lacrimal gland of the rat studied by micropuncture and catheterization techniques

1972 • 80 citations

Chapter 25 Membrane Recycling in Secretory Cells: Implications for Traffic of Products and Specialized Membranes within the Golgi Complex

1981 • 80 citations

M3 muscarinic acetylcholine receptor coupling to PLC in rat exorbital lacrimal acinar cells

1993 • 79 citations

Laboratory diagnosis of ophthalmic sarcoidosis

1984 • 75 citations

Comparative influence of steroid hormones and immunosuppressive agents on autoimmune expression in lacrimal glands of a female mouse model of Sjögren's syndrome.

1994 • 75 citations

Adrenocorticotropic Hormone and α‐Melanocyte‐Stimulating Hormone Induce Secretion and Protein Phosphorylation in the Rat Lacrimal Gland by Activation of a cAMP‐Dependent Pathway

1982 • 74 citations

Changes in rabbit lacrimal gland fluid osmolarity with flow rate.

1982 • 71 citations

Epstein-Barr Virus and the Lacrimal Gland Pathology of Sjögren’s Syndrome

1994 • 71 citations

Autonomic control of lacrimal protein secretion.

1981 • 71 citations

Post-mortem prevalence of lymphocytic infiltration of the lacrymal gland: A comparative study in autoimmune and non-autoimmune diseases

1984 • 68 citations

The lacrimal glands of the rat and the guinea pig are innervated by nerve fibers containing immunoreactivities for substance P and vasoactive intestinal polypeptide

1984 • 68 citations

Effect of Topical Cyclosporin A on Conjunctival T Cells in Patients with Secondary Sj??gren???s Syndrome

1993 • 67 citations

Keratoconjunctivitis sicca in the dog: a review of two hundred cases

1985 • 64 citations

The cytokine network in the pathogenesis of systemic lupus erythematosus and possible therapeutic implications

1994 • 63 citations

Keratoconjunctivitis Sicca in Male Patients Infected with Human Immunodeficiency Virus Type 1

1990 • 62 citations

Hormonal modulation of tear volume in the rat

1986 • 62 citations

Hypophysectomy-induced regression of female rat lacrimal glands: partial restoration and maintenance by dihydrotestosterone and prolactin.

1995 • 61 citations

Enhancement of thyrocyte HLA class II expression by thyroid stimulating hormone.

1987 • 60 citations

Immunohistochemical and enzymehistochemical studies of peptidergic, aminergic and cholinergic innervation of the lacrimal gland of the monkey (Macaca fuscata)

1992 • 59 citations

Modification of stimulated lacrimal gland flow by sympathetic nerve impulses in rabbit

1976 • 59 citations

Nuclear muscarinic acetylcholine receptors in corneal cells from rabbit.

1993 • 57 citations

Influence of gender and the endocrine environment on the distribution of androgen receptors in the lacrimal gland

1993 • 56 citations

The release of intracellular Ca2+ in lacrimal acinar cells by ?-, ?-adrenergic and muscarinic cholinergic stimulation: the roles of inositol trisphosphate and cyclic ADP-ribose

1995 • 55 citations

Testosterone-induced suppression of autoimmune disease in lacrimal tissue of a mouse model (NZB/NZW F1) of Sjögren's syndrome.

1991 • 53 citations

Detection of transforming growth factor-alpha mRNA and protein in rat lacrimal glands and characterization of transforming growth factor-alpha in human tears.

1996 • 51 citations

Immunohistochemical demonstration of epidermal growth factor in the lacrimal and submandibular glands of rats

1990 • 50 citations

Hormonal influence on the secretory immune system of the eye: androgen modulation of IgA levels in tears of rats.

1985 • 49 citations

Hormonal influence on the secretory immune system of the eye: endocrine interactions in the control of IgA and secretory component levels in tears of rats.

1987 • 47 citations

Prolactin localization, binding, and effects on peroxidase release in rat exorbital lacrimal gland.

1992 • 47 citations

Basic fibroblast growth factor (FGFb) and epidermal growth factor (EGF) receptor messenger RNA production in human lacrimal gland.

1991 • 47 citations

Changes in contact lens comfort related to the menstrual cycle and menopause. A review of articles.

1993 • 45 citations

Fluid phase endocytosis by isolated rabbit lacrimal gland acinar cells

1995 • 44 citations

Cholinergic activation of phospholipase D in lacrimal gland acini is independent of protein kinase C and calcium

1995 • 44 citations

Neuropeptides and the innervation of the avian lacrimal gland.

1989 • 41 citations

Experimental autoimmune dacryoadenitis. II. Harderian gland disease in the rat.

1987 • 40 citations

Substrate Modulation of Morphology, Growth, and Tear Protein Production by Cultured Human Lacrimal Gland Epithelial Cells

1995 • 39 citations

The effect of aging on the secretory immune system of the eye.

1988 • 38 citations

Regulation of autoimmune response

1994 • 38 citations

Traffic of major histocompatibility complex class II molecules in rabbit lacrimal gland acinar cells.

1994 • 37 citations

Class II antigen expression by lacrimal epithelial cells. An updated working hypothesis for antigen presentation by epithelial cells.

1991 • 37 citations

Norepinephrine-responsive beta-adrenergic receptors in rabbit lacrimal gland

1973 • 35 citations

Immunological Characterization and Possible Origin of Plasminogen Activator in Human Tear Fluid

1983 • 34 citations

The immunogenetics of Sjögren's syndrome.

1992 • 33 citations

Plasma membrane internalization and recycling in rabbit lacrimal acinar cells.

1993 • 32 citations

Potential therapeutic approach for the hormonal treatment of lacrimal gland dysfunction in Sjögren's syndrome

1992 • 31 citations

Translocation of the Nuclear Autoantigen La to the Cell Surface of Herpes Simplex Virus Type 1 Infected Cells

1992 • 30 citations

INTERFERON-GAMMA AND EPITHELIAL CELL ACTIVATION IN SJÖGREN'S SYNDROME

1995 • 30 citations

LYMPHOCYTIC INFILTRATES AND EPITHELIAL HLA-DR EXPRESSION IN LIP SALIVARY GLANDS IN CONNECTIVE TISSUE DISEASE PATIENTS LACKING SICCA: A PROSPECTIVE STUDY

1989 • 29 citations

The relationship between secretion of retinol and protein by the lacrimal gland.

1989 • 28 citations

Sex-dependent parameters related to electrolyte, water and glycoprotein secretion in rabbit lacrimal glands

1993 • 27 citations

THE IMMUNOGENETICS OF SJÖGREN’S SYNDROME

1992 • 25 citations

Focal Adenitis in Lacrimal and Salivary Glands

1988 • 25 citations

Carbachol-induced increase of Na⁺/H⁺antiport and recruitment of Na⁺, K⁺-ATPase in rabbit lacrimal acini

1993 • 25 citations

Stimulation of rabbit lacrimal gland secretion with biologically active peptides

1988 • 24 citations

Protein secretion in lacrimal gland: alpha 1-beta-adrenergic synergism

1986 • 24 citations

Lysosomal hydrolases in tears and the lacrimal gland: effect of acetylsalicylic acid on the release from the lacrimal gland.

1980 • 24 citations

A Model to Study Viral and Cytokine Involvement in Sjogren's Syndrome

1994 • 24 citations

Isolation and subcellular fractionation analysis of acini from rabbit lacrimal glands.

1992 • 23 citations

Immunohistochemical Evidence for the Presence of Vasopressin in the Rat Harderian Gland, Retina and Lacrimal Gland

1994 • 23 citations

Components of the protein kinase C pathway induce Ia expression after injection into macrophages.

1992 • 23 citations

Tear Flow in Cyclosporine Recipients

1995 • 22 citations

Secretagogue-induced redistributions of Na,K-ATPase in rat lacrimal acini.

1991 • 21 citations

DNA polymorphism in cytokine genes based on length variation in simple-sequence tandem repeats

1993 • 20 citations

Effect of phorbol esters on rat lacrimal gland protein secretion.

1988 • 19 citations

Proenkephalin a derivatives in lacrimal gland: Occurrence and regulation of lacrimal function

1992 • 19 citations

Identification of G proteins in lacrimal gland.

1995 • 18 citations

Endogenous antigen presentation by autoantigen-transfected Epstein-Barr virus-lymphoblastoid cells. I. Generation of human thyroid peroxidase-reactive T cells and their T cell receptor repertoire.

1993 • 17 citations

[Ocular and metabolic findings in patients on oral contraceptives].

1973 • 17 citations

α1-Adrenergic Agonist-stimulated Protein Secretion in Rat Exorbital Lacrimal Gland Acini

1994 • 17 citations

Antigen Presentation in the Pathogenesis of Autoimmune Endocrine Disease

1995 • 17 citations

The identification of transferrin, an iron-binding protein in rabbit tears

1984 • 16 citations

Innervation and Mast Cells of the Rat Lacrimal Gland: the Effects of Age

1994 • 16 citations

Surface and Intracellular Pools of Na,K-ATPase Catalytic and Immuno-activities in Rat Exorbital Lacrimal Gland

1993 • 16 citations

Autostimulatory growth factors produced by Sjögren's syndrome B cell lines

1989 • 16 citations

Role of calcium in cholinergic stimulation of lacrimal gland protein secretion

1985 • 14 citations

Experimental autoimmune dacryoadenitis: purification and characterization of a lacrimal gland antigen.

1992 • 13 citations

T‐lymphocyte subsets in the human lacrimal gland

1988 • 13 citations

Protein Secretion and the Identification of Neurotransmitters in the Isolated Pig Lacrimal Gland

1994 • 13 citations

Immunogold Localization of Prolactin in Acinar Cells of Lacrimal Gland

1994 • 11 citations

Identification of lacrimal gland associated immunomodulatory activities having differential effects on T and B cell proliferative responses.

1990 • 11 citations

Membrane Expression of Nuclear Antigens: a model for Autoimmunity in Sjogren's Syndrome?

1992 • 11 citations

On the Issue of Inappropriate HLA Class II Expression on Endocrine Cells: An Answer to a Sceptic

1995 • 10 citations

Ocular immune privilege in the immunosuppressive intraocular microenvironment

1995 • 10 citations

Activity of DNA and RNA polymerases in resurfacing rabbit corneal epithelium

1987 • 9 citations

Effects of topical carbamylcholine on corneal epithelial resurfacing.

1987 • 9 citations

Complement inhibitors in tears of different species

1984 • 8 citations

Lacrimal gland-derived lymphocyte proliferation potentiating factor.

1993 • 5 citations

Autoimmune endocrine diseases

1992 • 2 citations