Animal models of systemic sclerosis: insights into systemic sclerosis pathogenesis and potential therapeutic approaches

CD19-dependent B lymphocyte signaling thresholds influence skin fibrosis and autoimmunity in the tight-skin mouse

2002 • 220 citations

CD19-dependent B lymphocyte signaling thresholds influence skin fibrosis and autoimmunity in the tight-skin mouse

2002 • 195 citations

Halofuginone, an Inhibitor of Type-I Collagen Synthesis and Skin Sclerosis, Blocks Transforming-Growth-Factor-β-Mediated Smad3 Activation in Fibroblasts

2002 • 165 citations

Fibroblast-specific Expression of a Kinase-deficient Type II Transforming Growth Factor β (TGFβ) Receptor Leads to Paradoxical Activation of TGFβ Signaling Pathways with Fibrosis in Transgenic Mice

2003 • 135 citations

Sustained Activation of Fibroblast Transforming Growth Factor-β/Smad Signaling in a Murine Model of Scleroderma

2003 • 121 citations

A modified model of graft‐versus‐host–induced systemic sclerosis (scleroderma) exhibits all major aspects of the human disease

2004 • 120 citations

Disrupting the IL-4 gene rescues mice homozygous for the tight-skin mutation from embryonic death and diminishes TGF-β production by fibroblasts

2002 • 107 citations

Hepatocyte Growth Factor Modulates Matrix Metalloproteinases and Plasminogen Activator/Plasmin Proteolytic Pathways in Progressive Renal Interstitial Fibrosis

2003 • 96 citations

Repression of Bleomycin-Induced Pneumopathy by TNF

2003 • 92 citations

Role of Monocyte Chemoattractant Protein-1 and its Receptor,CCR-2, in the Pathogenesis of Bleomycin-Induced Scleroderma

2003 • 86 citations

Murine gammaherpes virus as a cofactor in the development of pulmonary fibrosis in bleomycin resistant mice

2002 • 75 citations

Modulation of PDGF-C and PDGF-D expression during bleomycin-induced lung fibrosis

2004 • 70 citations

Molecular mechanisms of interleukin‐4–induced up‐regulation of type I collagen gene expression in murine fibroblasts

2003 • 60 citations

Possible Role of Apoptosis in the Pathogenesis of Bleomycin-Induced Scleroderma

2004 • 57 citations

Mutant fibrillin 1 from tight skin mice increases extracellular matrix incorporation of microfibril‐associated glycoprotein 2 and type I collagen

2004 • 55 citations

Hepatocyte growth factor both prevents and ameliorates the symptoms of dermal sclerosis in a mouse model of scleroderma

2004 • 43 citations

Time-Temperature Relationships in Thermal Blister Formation*

1949 • 36 citations

Murine animal models of systemic sclerosis

2002 • 36 citations

Halofuginone inhibition of COL1A2 promoter activity via a c‐Jun–dependent mechanism

2002 • 34 citations

Animal models for scleroderma: An update

2002 • 31 citations

Effect of Halofuginone on the Development of Tight Skin (TSK) Syndrome

2002 • 30 citations

Disruption of tumor necrosis factor receptor p55 impairs collagen turnover in experimentally induced sclerodermic skin fibroblasts

2003 • 22 citations