Circulating interleukin-6 as a tumor marker for hepatocellular carcinoma

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1999 • 478 citations

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2003 • 378 citations

Serum interleukin 6 as a prognostic factor in patients with prostate cancer.

2000 • 354 citations

Serum interleukin‐6 levels reflect the disease status of colorectal cancer

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1999 • 283 citations

Requirement of ErbB2 for signalling by interleukin-6 in prostate carcinoma cells

1998 • 282 citations

Interleukin-6 Protects against Fas-mediated Death by Establishing a Critical Level of Anti-apoptotic Hepatic Proteins FLIP, Bcl-2, and Bcl-xL

2001 • 282 citations

The soluble human IL-6 receptor. Mutational characterization of the proteolytic cleavage site.

1994 • 275 citations

Etk/Bmx, a tyrosine kinase with a pleckstrin-homology domain, is an effector of phosphatidylinositol 3′-kinase and is involved in interleukin 6-induced neuroendocrine differentiation of prostate cancer cells

1998 • 249 citations

Interleukin-6 and Soluble Interleukin-6 Receptor: Direct Stimulation of gp130 and Hematopoiesis

1998 • 247 citations

A review of the cytokine network in multiple myeloma

2003 • 218 citations

The role of transsignalling via the agonistic soluble IL-6 receptor in human diseases

2002 • 202 citations

Soluble interleukin‐6 receptors released from T cell or granulocyte/macrophage cell lines and human peripheral blood mononuclear cells are generated through an alternative splicing mechanism

1994 • 197 citations

Interleukin-6 and Soluble Interleukin-6 Receptor: Direct Stimulation of gp130 and Hematopoiesis

1998 • 192 citations

Managing Cancer-Related Anorexia/Cachexia

2001 • 172 citations

Interleukin-6, tumour necrosis factor α and interleukin-1β in patients with renal cell carcinoma

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Quantitative evaluation of oxidative stress, chronic inflammatory indices and leptin in cancer patients: Correlation with stage and performance status

2001 • 155 citations

Marked Elevation of Serum Interleukin-6 in Patients With Cholangiocarcinoma

1998 • 145 citations

Elevated Serum Interleukin-6 Levels in Patients with Pancreatic Cancer

1998 • 140 citations

Coexpression of IL-6 and soluble IL-6R causes nodular regenerative hyperplasia and adenomas of the liver

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Hemoglobin levels correlate with interleukin-6 levels in patients with advanced untreated epithelial ovarian cancer: role of inflammation in cancer-related anemia

2005 • 133 citations

Serum Evaluation of Interleukin 6 in Ovarian Cancer Patients

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Increased intrahepatic messenger RNA expression of interleukins 2, 6, and 8 in human cirrhosis

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Impairment of natural killer functions by interleukin 6 increases lymphoblastoid cell tumorigenicity in athymic mice.

1991 • 91 citations

Interleukin-6 Serum Level Correlates with Survival in Advanced Gastrointestinal Cancer Patients but Is Not an Independent Prognostic Indicator

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Serum values of proinflammatory cytokines are inversely correlated with serum leptin levels in patients with advanced stage cancer at different sites

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Megestrol acetate in neoplastic anorexia/cachexia: clinical evaluation and comparison with cytokine levels in patients with head and neck carcinoma treated with neoadjuvant chemotherapy

1995 • 77 citations

Human interleukin 6 gene is activated by hepatitis B virus-X protein in human hepatoma cells.

1998 • 76 citations

Circulating IL‐6 and sIL‐6R in Patients with Hepatocellular Carcinoma

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CANCER CACHEXIA IS MEDIATED IN PART BY THE INDUCTION OF IL-6-LIKE CYTOKINES FROM THE SPLEEN

2001 • 55 citations

Hepatocyte growth factor/scatter factor (HGF/SF) signals via the STAT3/APRF transcription factor in human hepatoma cells and hepatocytes

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Prognostic value of serum biological markers in patients with hepatocellular carcinoma.

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1996 • 33 citations

Interleukin-6, CD45 and the Src-Kinases in Myeloma Cell Proliferation

2003 • 31 citations

Medroxyprogesterone Acetate Decreases Secretion of Interleukin-6 and Parathyroid Hormone-Related Protein in a New Anaplastic Thyroid Cancer Cell Line, KTC-2

2003 • 30 citations

Medroxyprogesterone acetate treatment reduces serum interleukin-6 levels in patients with metastatic breast carcinoma

1996 • 29 citations

Effect of IL-6 overexpression on the metastatic potential of rat hepatocellular carcinoma cells

1998 • 22 citations

Expression of the hepatocyte growth factor-like protein gene in human hepatocellular carcinoma and interleukin-6-induced increased expression in hepatoma cells

1999 • 21 citations

Signal transducer and activator of transcription STAT3 plays a major role in gp130-mediated acute phase protein gene activation.

2003 • 21 citations

Retarded Liver Growth in Interleukin-6-Deficient and Tumor Necrosis Factor Receptor-1-Deficient Mice*

2001 • 20 citations

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Interleukin 6 and cancer treatment.

1991 • 13 citations

Interleukin-6, CD45 and the Src-Kinases in Myeloma Cell Proliferation

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