Heat shock proteins, tumor immunogenicity and antigen presentation: an integrated view

Tolerance, Danger, and the Extended Family

1994 • 4,654 citations

Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs

1998 • 2,378 citations

Role of Bone Marrow-Derived Cells in Presenting MHC Class I-Restricted Tumor Antigens

1994 • 1,185 citations

Signals and signs for lymphocyte responses

1994 • 868 citations

A Mechanism for the Specific Immunogenicity of Heat Shock Protein-Chaperoned Peptides

1995 • 838 citations

Identification of human cancers deficient in antigen processing.

1993 • 625 citations

Heat Shock Protein–Peptide Complexes, Reconstituted In Vitro, Elicit Peptide-specific Cytotoxic T Lymphocyte Response and Tumor Immunity

1997 • 567 citations

Heat Shock Proteins Come of Age: Primitive Functions Acquire New Roles in an Adaptive World

1998 • 560 citations

Human 60-kDa Heat-Shock Protein: A Danger Signal to the Innate Immune System

1999 • 474 citations

Tumor immunogenicity is determined by the mechanism of cell death via induction of heat shock protein expression

1998 • 449 citations

Recognition by Human V _γ 9/V _δ 2 T Cells of a GroEL Homolog on Daudi Burkitt's Lymphoma Cells

1990 • 357 citations

Specific interaction between the p53 cellular tumour antigen and major heat shock proteins

1986 • 354 citations

Cross-priming of minor histocompatibility antigen-specific cytotoxic T cells upon immunization with the heat shock protein gp96.

1995 • 339 citations

Loss of transporter protein, encoded by the TAP-1 gene, is highly correlated with loss of HLA expression in cervical carcinomas.

1994 • 333 citations

Immune response to p53 is dependent upon p53/HSP70 complexes in breast cancers.

1992 • 281 citations

Tumor Eradication by Adoptive Transfer of Cytototic T Lymphocytes

1992 • 281 citations

Minor H Antigens Introduced on H-2 Different Stimulating Cells Cross-React at the Cytotoxic T Cell Level during in Vivo Priming

1976 • 253 citations

Heat shock fusion proteins as vehicles for antigen delivery into the major histocompatibility complex class I presentation pathway

1997 • 253 citations

Isolation of an immunodominant viral peptide that is endogenously bound to the stress protein GP96/GRP94.

1996 • 222 citations

Mechanisms of rejection induced by tumor cell-targeted gene transfer of interleukin 2, interleukin 4, interleukin 7, tumor necrosis factor, or interferon gamma.

1993 • 221 citations

Immunization with a Lymphocytic Choriomeningitis Virus Peptide Mixed with Heat Shock Protein 70 Results in Protective Antiviral Immunity and Specific Cytotoxic T Lymphocytes

1998 • 193 citations

Gamma/delta T cell clones and natural killer cell clones mediate distinct patterns of non-major histocompatibility complex-restricted cytolysis.

1990 • 176 citations

Do heat shock proteins control the balance of T-cell regulation in inlammatory diseases?

1998 • 171 citations

Tumor Antigens

1992 • 138 citations

Loss of transporter in antigen processing 1 transport protein and major histocompatibility complex class I molecules in metastatic versus primary breast cancer.

1995 • 137 citations

Mycobacterial heat‐shock proteins as carrier molecules

1991 • 122 citations

Mycobacterial heat‐shock proteins as carrier molecules. II: The use of the 70‐kDa mycobacterial heat‐shock protein as carrier for conjugated vaccinescan circumvent the need for adjuvants and Bacillus Calmette Guérin priming)

1992 • 114 citations

Hsp72-mediated augmentation of MHC class I surface expression and endogenous antigen presentation

1998 • 112 citations

Molecular chaperones in antigen presentation

1995 • 103 citations

Response of Mammalian Cells to Metabolic Stress; Changes in Cell Physiology and Structure/Function of Stress Proteins

1991 • 103 citations

Tumor cells transfected with a bacterial heat-shock gene lose tumorigenicity and induce protection against tumors.

1993 • 98 citations

Isolation of processed, H-2Kb -binding ovalbumin-derived peptides associated with the stress proteins HSP70 and GP96

1998 • 96 citations

Down-regulation of the MHC class I antigen-processing machinery after oncogenic transformation of murine fibroblasts

1998 • 90 citations

Co-segregation of tumor immunogenicity with expression of inducible but not constitutive hsp70 in rat colon carcinomas.

1995 • 90 citations

Heat shock protein 65 induces CD62e, CD106, and CD54 on cultured human endothelial cells and increases their adhesiveness for monocytes and granulocytes.

1996 • 74 citations

Synthetic peptides non‐covalently bound to bacterial hsp 70 elicit peptide‐specific T‐cell responses in vivo

1996 • 74 citations

Gamma delta T cell recognition of tumor Ig peptide.

1995 • 64 citations

Suppression of MHC class I antigens in oncogenic transformants: association with decreased recognition by cytotoxic T lymphocytes.

1996 • 54 citations

Mycobacterial 65-kilodalton heat shock protein induces tumor necrosis factor alpha and interleukin 6, reactive nitrogen intermediates, and toxoplasmastatic activity in murine peritoneal macrophages

1995 • 47 citations

Exogenous heat shock protein hsp70 activates potassium channels in U937 cells

1996 • 36 citations

Molecular chaperones in the processing and presentation of antigen to helper T cells

1994 • 35 citations

Tumor Immunology: An Overview

1993 • 33 citations

Restoration of MHC Class I Surface Expression and Endogenous Antigen Presentation by a Molecular Chaperone

1997 • 29 citations

Heat Shock Protein Expression in Target Cells Infected with Low Levels of Replication-Competent Virus Contributes to the Immunogenicity of Adenoviral Vectors

1999 • 26 citations