DNA fragments in the blood plasma of cancer patients: quantitations and evidence for their origin from apoptotic and necrotic cells.

Methods of Enzymatic Analysis

1975 • 20,446 citations

Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands.

1996 • 5,667 citations

A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4

1993 • 3,680 citations

Endothelial Leukocyte Adhesion Molecule 1: an Inducible Receptor for Neutrophils Related to Complement Regulatory Proteins and Lectins

1989 • 2,045 citations

5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers

1995 • 2,000 citations

Alterations in DNA Methylation: A Fundamental Aspect of Neoplasia

1997 • 1,960 citations

Lethal effect of the anti-Fas antibody in mice

1993 • 1,915 citations

Intracellular Adenosine Triphosphate (ATP) Concentration: A Switch in the Decision Between Apoptosis and Necrosis

1997 • 1,851 citations

Free DNA in the serum of cancer patients and the effect of therapy.

1977 • 1,708 citations

Quantitative Analysis of Fetal DNA in Maternal Plasma and Serum: Implications for Noninvasive Prenatal Diagnosis

1998 • 1,629 citations

Inactivation of the CDKN2/p16/MTS1 gene is frequently associated with aberrant DNA methylation in all common human cancers.

1995 • 1,353 citations

Detection of aberrant promoter hypermethylation of tumor suppressor genes in serum DNA from non-small cell lung cancer patients.

1999 • 920 citations

Apoptotic DNA Fragmentation

2000 • 885 citations

Neoplastic Characteristics of the DNA Found in the Plasma of Cancer Patients

1989 • 687 citations

Microsatellite alterations in plasma DNA of small cell lung cancer patients

1996 • 656 citations

Microsatellite alterations in serum DNA of head and neck cancer patients

1996 • 653 citations

Frequency of homozygous deletion at p16/CDKN2 in primary human tumours

1995 • 653 citations

High frequency of p16 (CDKN2/MTS-1/INK4A) inactivation in head and neck squamous cell carcinoma.

1996 • 587 citations

Hypermethylation-associated inactivation indicates a tumor suppressor role for p15INK4B.

1996 • 585 citations

Gene promoter hypermethylation in tumors and serum of head and neck cancer patients.

2000 • 540 citations

Detection of aberrant p16 methylation in the plasma and serum of liver cancer patients.

1999 • 507 citations

Soluble normal and mutated DNA sequences from single-copy genes in human blood.

1994 • 478 citations

Detection of circulating tumour DNA in the blood (plasma/serum) of cancer patients.

1999 • 450 citations

Apoptosis: The importance of being eaten

1998 • 349 citations

A novel procedure for quantitative polymerase chain reaction by coamplification of competitive templates

1992 • 272 citations

Plasma DNA as a marker of cancerous cell death. Investigations in patients suffering from lung cancer and in nude mice bearing human tumours

1995 • 258 citations

Silencing of p16/CDKN2 expression in human gliomas by methylation and chromatin condensation.

1996 • 251 citations

The novel SAR-binding domain of scaffold attachment factor A (SAF-A) is a target in apoptotic nuclear breakdown

1997 • 138 citations

Microsatellite analysis of plasma DNA from patients with clear cell renal carcinoma.

1998 • 136 citations

Depletion of Hepatic Glutathione Prevents Death Receptor-Dependent Apoptotic and Necrotic Liver Injury in Mice

2000 • 73 citations

Apoptosis in serum of patients with solid tumours.

1999 • 65 citations

Radioimmunoassay for nanogram quantities of DNA

1975 • 64 citations

Cytokine-mediated hepatic apoptosis

1998 • 62 citations

Apoptotic Cleavage of Scaffold Attachment Factor A (SAF-A) by Caspase-3 Occurs at a Noncanonical Cleavage Site

2000 • 53 citations

[Plasma DNA level as a tumor marker in primary lung cancer].

1990 • 51 citations

Improved Polymerase Chain Reaction Detection of Clonally Rearranged T-Cell Receptor β Chain Genes

1998 • 24 citations

DNA-Methylation of the E-Selectin Promoter Represses NF-κB Transactivation

1993 • 24 citations

T-cell responses at the host: tumour interface

1986 • 19 citations