The Efficiency Concept in Pharmacodynamics

Understanding the Dose-Effect Relationship

1981 • 1,111 citations

The Concise Oxford Dictionary of Current English

1929 • 1,082 citations

Comparison of four basic models of indirect pharmacodynamic responses

1993 • 780 citations

A randomized trial to evaluate the effect of schedule on the activity of etoposide in small-cell lung cancer.

1989 • 467 citations

Continuous infusion of beta-lactam antibiotics

1992 • 338 citations

Electroencephalographic Quantitation of Opioid Effect

1991 • 325 citations

Diuretic efficacy of high dose furosemide in severe heart failure: Bolus injection versus continuous infusion

1996 • 317 citations

Kinetics of pharmacologic response I. Proposed relationships between response and drug concentration in the intact animal and man

1968 • 303 citations

Loop Diuretics for Chronic Renal Insufficiency: A Continuous Infusion Is More Efficacious Than Bolus Therapy

1991 • 178 citations

Rate of increase in the plasma concentration of nifedipine as a major determinant of its hemodynamic effects in humans

1987 • 178 citations

Tubular chloride transport and the mode of action of some diuretics

1976 • 156 citations

Pharmacokinetic-pharmacodynamic modeling of activity of ceftazidime during continuous and intermittent infusion

1997 • 139 citations

Continuous Infusion of ??-Lactam Antibiotics

1998 • 130 citations

Intermittent Administration of Furosemide vs Continuous Infusion Preceded by a Loading Dose for Congestive Heart Failure

1992 • 129 citations

Pharmacodynamic analysis of the furosemide-probenecid interaction in man

1979 • 126 citations

Renal tubular secretion and effects of furosemide

1980 • 123 citations

Pharmacokinetic dosing in prophylactic treatment of hemophilia A

1993 • 114 citations

The time course of delivery of furosemide into urine: An independent determinant of overall response

1982 • 109 citations

Acute tolerance to furosemide diuresis in humans. Pharmacokinetic-pharmacodynamic modeling.

1985 • 107 citations

Relation between morphine pharmacokinetics and analgesia

1978 • 90 citations

Pharmacodynamic modeling of furosemide tolerance after multiple intravenous administration*

1996 • 89 citations

Diuresis with continuous infusion of furosemide after cardiac surgery

1983 • 79 citations

Pharmacokinetic Optimisation of Cancer Chemotherapy

1997 • 74 citations

Influence of probenecid and spironolactone on furosemide kinetics and dynamics in man

1977 • 71 citations

Effects of probenecid on furosemide kinetics and natriuresis in man

1977 • 71 citations

Protocol-guided diuretic management

1997 • 65 citations

Opposing effects of apomorphine on pain in rats. Evaluation of the dose-response curve

1983 • 63 citations

Pharmacokinetic-pharmacodynamic modeling in drug development: Application to the investigational opioid trefentanil

1994 • 62 citations

Diuretic efficiency of furosemide during continuous administration versus bolus injection in healthy volunteers

1992 • 58 citations

Effect of bolus injection versus continuous infusion of furosemide on diuresis and neurohormonal activation in patients with severe congestive heart failure

1997 • 55 citations

Pharmacodynamics of Torsemide Administered as an Intravenous Injection and as a Continuous Infusion to Patients with Congestive Heart Failure

1996 • 54 citations

Kinetics and dynamics of furosemide and slow-acting furosemide

1982 • 46 citations

The In Vivo Study of Drug Action

1994 • 42 citations

Role of duration of diuretic effect in preventing sodium retention*

1997 • 42 citations

Interchangeability and Predictive Performance of Empirical Tolerance Models

1999 • 36 citations

Pharmacokinetic Optimisation of Anticancer Therapy

1991 • 35 citations

Diuretic effect and diuretic efficiency after intravenous dosage of frusemide [see comments]

1990 • 34 citations

Severe Musculoskeletal Symptoms During Continuous Infusion of Bumetanide

1997 • 30 citations

Role of dosage regimen in controlling indirect pharmacodynamic responses

1998 • 29 citations

Discrepancy between bioavailability as estimated from urinary recovery of frusemide and total diuretic effect.

1992 • 27 citations

Patient-Controlled Analgesia

1993 • 26 citations

Curative chemotherapy for acute myeloid leukemia: the development of high-dose ara-C from the laboratory to bedside

1996 • 26 citations

Pharmacokinetic and pharmacodynamic models of the antistaphylococcal effects of meropenem and cloxacillin in vitro and in experimental infection

1997 • 24 citations

Increased nonrenal clearance and increased diuretic efficiency of furosemide in cystic fibrosis

1988 • 23 citations

Effect of dosage regimen on natriuretic response to furosemide

1975 • 22 citations

Loop Diuretics

1987 • 18 citations

The influence of food intake on the effect of two controlled release formulations of furosemide

1995 • 18 citations

Urinary iron excretion depends on the mode of administration of the oral iron chelator 1,2-dimethyl-3-hydroxypyrid-4-one in patients with homozygous β-thalassemia

1994 • 15 citations

Natriuretic efficiency of frusemide as a consequence of drug input rate

1997 • 15 citations

Pharmacokinetics of 1-beta-D-arabinofuranosylcytosine 5'-triphosphate in leukemic cells after intravenous and subcutaneous administration of 1-beta-D-arabinofuranosylcytosine.

1985 • 15 citations

Comparison of 6‐Hour Infusion versus Bolus Furosemide in Premature Infants

1998 • 14 citations

The influence of drug input rate on the development of tolerance to frusemide

1998 • 14 citations

Theophylline Improves Measurements of Respiratory Muscle Efficiency

1996 • 13 citations

Increasing the accumulation of daunorubicin in human leukemic cells by prolonging the infusion time

1989 • 10 citations

The influence of co‐administered organic acids on the kinetics and dynamics of frusemide.

1991 • 9 citations

Diuretic effect and disposition of furosemide in cystic fibrosis

1991 • 4 citations

Treatment schedule dependency of antitumor effect of deoxyspergualin.

1991 • 4 citations